Regional specificity of the cingulate cortex thickness
association with the intensity of psilocybin experience: a
replication study

J 2025

Regional specificity of the cingulate cortex thickness association with the intensity of psilocybin experience: a replication study

GREGUS, David; Jaroslav HLINKA; Filip TYLS; Vojtech VIKTORIN; Michaela VIKTORINOVA et al.

Základní údaje

Originální název

Regional specificity of the cingulate cortex thickness association with the intensity of psilocybin experience: a replication study

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Vydání

Psychopharmacology, New York, Springer, 2025, 0033-3158

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30230 Other clinical medicine subjects

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.300 v roce 2024

Organizační jednotka

CZECRIN IV

DOI

https://doi.org/10.1007/s00213-025-06983-9

UT WoS

001638819000001

Klíčová slova česky

Psilocybin; Cingulate cortex; Cortical thickness; Psychedelic experience; Replication study

Klíčová slova anglicky

Psilocybin; Cingulate cortex; Cortical thickness; Psychedelic experience; Replication study

Štítky

CZECRIN, Excelence Science, NÚDZ, RIV, user, článek v časopise

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 1. 2026 11:07, Bc. Hana Vladíková, BBA

Anotace

V originále

Rationale Individual variability in psilocybin response is a major challenge for psychedelic-assisted therapy, with structural brain features potentially serving as predictive biomarkers. (Lewis et al. Biomedicines 8(2):34 2020) reported that rostral anterior cingulate cortex thickness predicted emotional experiences under psilocybin, suggesting cortical morphometry as a marker of psychedelic responsivity. Objectives This study sought to replicate and extend these findings by examining associations between cingulate thickness and psilocybin-induced altered states of consciousness using comprehensive assessment and rigorous statistical control. Methods Twenty-five healthy participants underwent a double-blind, placebo-controlled crossover design with psilocybin (0.26 mg/kg) and placebo. High-resolution T1-weighted magnetic resonance imaging (MRI) measured cortical thickness across cingulate subregions. Subjective effects were assessed with the Altered States of Consciousness (ASC) questionnaire. Analyses applied false discovery rate (FDR) correction for multiple comparisons. Results The primary Lewis et al. finding-that rostral anterior cingulate cortex thickness predicts emotional psilocybin responses-showed a comparable effect size (beta = 0.523 vs. their range 0.324-0.572) that did not achieve statistical significance (p = 0.297), likely reflecting limited statistical power given our smaller sample (N = 25 vs. N = 55). We identified an anterior-posterior gradient in cingulate thickness that significantly predicted psychedelic experience intensity (r = 0.676, FDR p = 0.0004). Conclusions Findings indicate that spatial organization within the cingulate cortex provides a neuroanatomical marker of variability in psychedelic response. Results highlight the importance of organizational patterns within the cingulate cortex, rather than focal regional measures, when predicting psychedelic effects.

Návaznosti

90249, velká výzkumná infrastruktura

Název: CZECRIN IV

Citovat

GREGUS, David; Jaroslav HLINKA; Filip TYLS; Vojtech VIKTORIN; Michaela VIKTORINOVA; Anna BRAVERMANOVA; Renata ANDROVICOVA; Veronika ANDRASHKO; Jakub KORCAK; Marek NIKOLIC; Petr ADAMEK; Michal BENES; Tomas PALENICEK a Jiri HORACEK. Regional specificity of the cingulate cortex thickness association with the intensity of psilocybin experience: a replication study. Psychopharmacology. New York: Springer, 2025, NA, NA, s. 1-10. ISSN 0033-3158. Dostupné z: https://doi.org/10.1007/s00213-025-06983-9.

@article{2548331,
   author = {Gregus, David and Hlinka, Jaroslav and Tyls, Filip and Viktorin, Vojtech and Viktorinova, Michaela and Bravermanova, Anna and Androvicova, Renata and Andrashko, Veronika and Korcak, Jakub and Nikolic, Marek and Adamek, Petr and Benes, Michal and Palenicek, Tomas and Horacek, Jiri},
   article_location = {New York},
   article_number = {NA},
   doi = {https://doi.org/10.1007/s00213-025-06983-9},
   keywords = {Psilocybin; Cingulate cortex; Cortical thickness; Psychedelic experience; Replication study},
   language = {eng},
   issn = {0033-3158},
   journal = {Psychopharmacology},
   title = {Regional specificity of the cingulate cortex thickness association with the intensity of psilocybin experience: a replication study},
   url = {https://link.springer.com/article/10.1007/s00213-025-06983-9?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot&getft_integrator=clarivate},
   volume = {NA},
   year = {2025}
}

TY  - JOUR
ID  - 2548331
AU  - Gregus, David - Hlinka, Jaroslav - Tyls, Filip - Viktorin, Vojtech - Viktorinova, Michaela - Bravermanova, Anna - Androvicova, Renata - Andrashko, Veronika - Korcak, Jakub - Nikolic, Marek - Adamek, Petr - Benes, Michal - Palenicek, Tomas - Horacek, Jiri
PY  - 2025
TI  - Regional specificity of the cingulate cortex thickness association with the intensity of psilocybin experience: a replication study
JF  - Psychopharmacology
VL  - NA
IS  - NA
SP  - 1-10
EP  - 1-10
PB  - Springer
SN  - 00333158
KW  - Psilocybin
KW  - Cingulate cortex
KW  - Cortical thickness
KW  - Psychedelic experience
KW  - Replication study
UR  - https://link.springer.com/article/10.1007/s00213-025-06983-9?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot&getft_integrator=clarivate
N2  - Rationale Individual variability in psilocybin response is a major challenge for psychedelic-assisted therapy, with structural brain features potentially serving as predictive biomarkers. (Lewis et al. Biomedicines 8(2):34 2020) reported that rostral anterior cingulate cortex thickness predicted emotional experiences under psilocybin, suggesting cortical morphometry as a marker of psychedelic responsivity. Objectives This study sought to replicate and extend these findings by examining associations between cingulate thickness and psilocybin-induced altered states of consciousness using comprehensive assessment and rigorous statistical control. Methods Twenty-five healthy participants underwent a double-blind, placebo-controlled crossover design with psilocybin (0.26 mg/kg) and placebo. High-resolution T1-weighted magnetic resonance imaging (MRI) measured cortical thickness across cingulate subregions. Subjective effects were assessed with the Altered States of Consciousness (ASC) questionnaire. Analyses applied false discovery rate (FDR) correction for multiple comparisons. Results The primary Lewis et al. finding-that rostral anterior cingulate cortex thickness predicts emotional psilocybin responses-showed a comparable effect size (beta = 0.523 vs. their range 0.324-0.572) that did not achieve statistical significance (p = 0.297), likely reflecting limited statistical power given our smaller sample (N = 25 vs. N = 55). We identified an anterior-posterior gradient in cingulate thickness that significantly predicted psychedelic experience intensity (r = 0.676, FDR p = 0.0004). Conclusions Findings indicate that spatial organization within the cingulate cortex provides a neuroanatomical marker of variability in psychedelic response. Results highlight the importance of organizational patterns within the cingulate cortex, rather than focal regional measures, when predicting psychedelic effects.
ER  -

GREGUS, David; Jaroslav HLINKA; Filip TYLS; Vojtech VIKTORIN; Michaela VIKTORINOVA; Anna BRAVERMANOVA; Renata ANDROVICOVA; Veronika ANDRASHKO; Jakub KORCAK; Marek NIKOLIC; Petr ADAMEK; Michal BENES; Tomas PALENICEK a Jiri HORACEK. Regional specificity of the cingulate cortex thickness association with the intensity of psilocybin experience: a replication study. \textit{Psychopharmacology}. New York: Springer, 2025, NA, NA, s.~1-10. ISSN~0033-3158. Dostupné z: https://doi.org/10.1007/s00213-025-06983-9.

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