Colloid cysts of the third ventricle show consistent expression
of PAX8 but lack other features of thyroid, müllerian or
intestinal differentiation

J 2026

Colloid cysts of the third ventricle show consistent expression of PAX8 but lack other features of thyroid, müllerian or intestinal differentiation

SOUKUP, Jiri; Eva TRABOULSI; Sarka LOPATOVA; Martin SYRUCEK; Miroslav KOBLIZEK et al.

Základní údaje

Originální název

Colloid cysts of the third ventricle show consistent expression of PAX8 but lack other features of thyroid, müllerian or intestinal differentiation

Autoři

SOUKUP, Jiri; Eva TRABOULSI; Sarka LOPATOVA; Martin SYRUCEK; Miroslav KOBLIZEK; Michal HENDRYCH; Marian SVAJDLER; Kristyna SICHOVA; Michaela MAY a David NETUKA

Vydání

Human pathology, Philadelphia, PA, W.B. Saunders Company, 2026, 0046-8177

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30109 Pathology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.600 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Colloid cyst of the 3rd ventricle; Rathke cleft cyst; Neurenteric cyst; Craniopharyngioma PAX8; SOX17; TTF1; Cadherin 17

Štítky

14110112, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 1. 2026 11:44, Mgr. Tereza Miškechová

Anotace

V originále

Colloid cyst of the 3rd ventricle (CC) is an unusual cystic lesion of uncertain histogenesis, occurring exclusively in the 3rd ventricle close to the foramen Monro. In the past, its pathogenic relationship to neurenteric cyst (NEC) of central nervous system or Rathke cleft cyst (RCC) has been suggested. Thus, we evaluated expression of selected tissue-specific transcription factors and other proteins to assess its putative origin. Tissue samples of 15 CCs (8 females and 7 males, mean age 46.7 years), 7 RCCs (7 females, mean age 45.6 years), 8 neurenteric cysts (5 females and 2 males, mean age 42.1 years, including 1 recurrent case), and 10 craniopharyngiomas (2 papillary and 8 adamantinomatous) were included. Immunohistochemical detections of PAX8 with C-terminus specific antibody, TTF1, SOX17, and cadherin 17 were performed in all the samples. The immunoreactivity was scored based on extent (0 %; <10 %; 10-50 %; >50 %) and intensity (weak, moderate, strong). All 15 cases of CCs were PAX8 positive (moderate to strong expression in >50 % in 13/15 cases), while no RCC, NEC or craniopharyngioma showed PAX8 immunoreactivity. Rare PAX8-positive cells were also observed in single cells of 50 % (3/6) of the choroid plexuses. No expression of TTF1 or SOX17 was detected in any of the cases and weak cadherin 17 expression was seen in scattered cells (<10 %) of one CC and RCC. Colloid cysts of the 3rd ventricle are consistently PAX8-positive, while they lack signs of thyroid, m & uuml;llerian or enteric differentiation. Furthermore, PAX8 can be used to distinguish CC from NEC, RCC, and craniopharyngiomas.

Návaznosti

MUNI/A/1621/2024, interní kód MU

Název: Patologie nádorových a nenádorových onemocnění

Investor: Masarykova univerzita, Patologie nádorových a nenádorových onemocnění

Citovat

SOUKUP, Jiri; Eva TRABOULSI; Sarka LOPATOVA; Martin SYRUCEK; Miroslav KOBLIZEK; Michal HENDRYCH; Marian SVAJDLER; Kristyna SICHOVA; Michaela MAY a David NETUKA. Colloid cysts of the third ventricle show consistent expression of PAX8 but lack other features of thyroid, müllerian or intestinal differentiation. Human pathology. Philadelphia, PA: W.B. Saunders Company, 2026, roč. 168, February 2026, s. 1-7. ISSN 0046-8177. Dostupné z: https://doi.org/10.1016/j.humpath.2025.106028.

@article{2548583,
   author = {Soukup, Jiri and Traboulsi, Eva and Lopatova, Sarka and Syrucek, Martin and Koblizek, Miroslav and Hendrych, Michal and Svajdler, Marian and Sichova, Kristyna and May, Michaela and Netuka, David},
   article_location = {Philadelphia, PA},
   article_number = {February 2026},
   doi = {https://doi.org/10.1016/j.humpath.2025.106028},
   keywords = {Colloid cyst of the 3rd ventricle; Rathke cleft cyst; Neurenteric cyst; Craniopharyngioma PAX8; SOX17; TTF1; Cadherin 17},
   language = {eng},
   issn = {0046-8177},
   journal = {Human pathology},
   title = {Colloid cysts of the third ventricle show consistent expression of PAX8 but lack other features of thyroid, müllerian or intestinal differentiation},
   url = {https://www.sciencedirect.com/science/article/pii/S0046817725003156},
   volume = {168},
   year = {2026}
}

TY  - JOUR
ID  - 2548583
AU  - Soukup, Jiri - Traboulsi, Eva - Lopatova, Sarka - Syrucek, Martin - Koblizek, Miroslav - Hendrych, Michal - Svajdler, Marian - Sichova, Kristyna - May, Michaela - Netuka, David
PY  - 2026
TI  - Colloid cysts of the third ventricle show consistent expression of PAX8 but lack other features of thyroid, müllerian or intestinal differentiation
JF  - Human pathology
VL  - 168
IS  - February 2026
SP  - 1-7
EP  - 1-7
PB  - W.B. Saunders Company
SN  - 00468177
KW  - Colloid cyst of the 3rd ventricle
KW  - Rathke cleft cyst
KW  - Neurenteric cyst
KW  - Craniopharyngioma PAX8
KW  - SOX17
KW  - TTF1
KW  - Cadherin 17
UR  - https://www.sciencedirect.com/science/article/pii/S0046817725003156
N2  - Colloid cyst of the 3rd ventricle (CC) is an unusual cystic lesion of uncertain histogenesis, occurring exclusively in the 3rd ventricle close to the foramen Monro. In the past, its pathogenic relationship to neurenteric cyst (NEC) of central nervous system or Rathke cleft cyst (RCC) has been suggested. Thus, we evaluated expression of selected tissue-specific transcription factors and other proteins to assess its putative origin. Tissue samples of 15 CCs (8 females and 7 males, mean age 46.7 years), 7 RCCs (7 females, mean age 45.6 years), 8 neurenteric cysts (5 females and 2 males, mean age 42.1 years, including 1 recurrent case), and 10 craniopharyngiomas (2 papillary and 8 adamantinomatous) were included. Immunohistochemical detections of PAX8 with C-terminus specific antibody, TTF1, SOX17, and cadherin 17 were performed in all the samples. The immunoreactivity was scored based on extent (0 %; <10 %; 10-50 %; >50 %) and intensity (weak, moderate, strong). All 15 cases of CCs were PAX8 positive (moderate to strong expression in >50 % in 13/15 cases), while no RCC, NEC or craniopharyngioma showed PAX8 immunoreactivity. Rare PAX8-positive cells were also observed in single cells of 50 % (3/6) of the choroid plexuses. No expression of TTF1 or SOX17 was detected in any of the cases and weak cadherin 17 expression was seen in scattered cells (<10 %) of one CC and RCC. Colloid cysts of the 3rd ventricle are consistently PAX8-positive, while they lack signs of thyroid, m & uuml;llerian or enteric differentiation. Furthermore, PAX8 can be used to distinguish CC from NEC, RCC, and craniopharyngiomas.
ER  -

SOUKUP, Jiri; Eva TRABOULSI; Sarka LOPATOVA; Martin SYRUCEK; Miroslav KOBLIZEK; Michal HENDRYCH; Marian SVAJDLER; Kristyna SICHOVA; Michaela MAY a David NETUKA. Colloid cysts of the third ventricle show consistent expression of PAX8 but lack other features of thyroid, müllerian or intestinal differentiation. \textit{Human pathology}. Philadelphia, PA: W.B. Saunders Company, 2026, roč.~168, February 2026, s.~1-7. ISSN~0046-8177. Dostupné z: https://doi.org/10.1016/j.humpath.2025.106028.

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