Sex-dependent impairment of antibody responses to tick-borne
encephalitis virus vaccination and infection in obese mice

J 2025

Sex-dependent impairment of antibody responses to tick-borne encephalitis virus vaccination and infection in obese mice

DVOŘÁK, Michal; Dominik ARBON; Jiří SALÁT; Andrea FOŘTOVÁ; David Pajuelo REGUERA et al.

Základní údaje

Originální název

Sex-dependent impairment of antibody responses to tick-borne encephalitis virus vaccination and infection in obese mice

Autoři

DVOŘÁK, Michal; Dominik ARBON; Jiří SALÁT; Andrea FOŘTOVÁ; David Pajuelo REGUERA; Tereza FRČKOVÁ; Jiří HOLOUBEK; Jana BALOUNOVA; Jan PROCHAZKA; Radislav SEDLACEK a Daniel RŮŽEK

Vydání

JOURNAL OF GENERAL VIROLOGY, LONDON, MICROBIOLOGY SOC, 2025, 0022-1317

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10607 Virology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.300 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/25:00144627

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

immune response; obesity; tick-borne encephalitis; tick-borne encephalitis virus; vaccination

Štítky

14314010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 1. 2026 14:13, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Obesity is a growing global health concern with profound effects on immune function and vaccine efficacy. This study investigated the impact of obesity on immune responses to tick- borne encephalitis virus (TBEV) vaccination and infection using a mouse model. Mice on a high- fat diet (HFD) exhibited increased body weight, fat mass and a pre- diabetic state compared to standard chow diet (SCD) controls. After vaccination with the TBEV vaccine (Encepur), HFD mice showed significantly lower TBEV- specific IgG titres and neutralizing antibody levels compared to SCD mice. Splenocyte counts per organ mass were significantly higher in vaccinated SCD mice compared to their HFD counterparts, correlating with the elevated IgG titres observed in the SCD group. These results underscore the critical role of diet in shaping the immune response and vaccine efficacy. Following TBEV infection, HFD mice did not display increased disease severity or elevated viral titres in the serum, spleen or brain relative to SCD controls, indicating that obesity did not exacerbate viral replication or dissemination. However, a sex- dependent effect of obesity on the humoral immune response was observed. Male HFD mice produced antibody titres comparable to their SCD counterparts, suggesting minimal impact of obesity on their immune response. In contrast, female HFD mice exhibited significant impairments in TBEV- specific IgG and neutralizing antibody production compared to female SCD mice, as well as both male HFD and male SCD groups. These findings highlight a complex interplay between obesity, sex and immune function, with obesity disproportionately impairing the immune response after TBEV vaccination and infection.

Návaznosti

GA23-07160S, projekt VaV

Název: Molekulární patogeneze alimentární infekce virem klíšťové encefalitidy.

Investor: Grantová agentura ČR, Molekulární patogeneze alimentární infekce virem klíšťové encefalitidy.

Citovat

DVOŘÁK, Michal; Dominik ARBON; Jiří SALÁT; Andrea FOŘTOVÁ; David Pajuelo REGUERA; Tereza FRČKOVÁ; Jiří HOLOUBEK; Jana BALOUNOVA; Jan PROCHAZKA; Radislav SEDLACEK a Daniel RŮŽEK. Sex-dependent impairment of antibody responses to tick-borne encephalitis virus vaccination and infection in obese mice. JOURNAL OF GENERAL VIROLOGY. LONDON: MICROBIOLOGY SOC, 2025, roč. 106, č. 10, s. 1-12. ISSN 0022-1317. Dostupné z: https://doi.org/10.1099/jgv.0.002161.

@article{2548630,
   author = {Dvořák, Michal and Arbon, Dominik and Salát, Jiří and Fořtová, Andrea and Reguera, David Pajuelo and Frčková, Tereza and Holoubek, Jiří and Balounova, Jana and Prochazka, Jan and Sedlacek, Radislav and Růžek, Daniel},
   article_location = {LONDON},
   article_number = {10},
   doi = {https://doi.org/10.1099/jgv.0.002161},
   keywords = {immune response; obesity; tick-borne encephalitis; tick-borne encephalitis virus; vaccination},
   language = {eng},
   issn = {0022-1317},
   journal = {JOURNAL OF GENERAL VIROLOGY},
   title = {Sex-dependent impairment of antibody responses to tick-borne encephalitis virus vaccination and infection in obese mice},
   url = {https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.002161},
   volume = {106},
   year = {2025}
}

TY  - JOUR
ID  - 2548630
AU  - Dvořák, Michal - Arbon, Dominik - Salát, Jiří - Fořtová, Andrea - Reguera, David Pajuelo - Frčková, Tereza - Holoubek, Jiří - Balounova, Jana - Prochazka, Jan - Sedlacek, Radislav - Růžek, Daniel
PY  - 2025
TI  - Sex-dependent impairment of antibody responses to tick-borne encephalitis virus vaccination and infection in obese mice
JF  - JOURNAL OF GENERAL VIROLOGY
VL  - 106
IS  - 10
SP  - 1-12
EP  - 1-12
PB  - MICROBIOLOGY SOC
SN  - 00221317
KW  - immune response
KW  - obesity
KW  - tick-borne encephalitis
KW  - tick-borne encephalitis virus
KW  - vaccination
UR  - https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.002161
N2  - Obesity is a growing global health concern with profound effects on immune function and vaccine efficacy. This study investigated the impact of obesity on immune responses to tick- borne encephalitis virus (TBEV) vaccination and infection using a mouse model. Mice on a high- fat diet (HFD) exhibited increased body weight, fat mass and a pre- diabetic state compared to standard chow diet (SCD) controls. After vaccination with the TBEV vaccine (Encepur), HFD mice showed significantly lower TBEV- specific IgG titres and neutralizing antibody levels compared to SCD mice. Splenocyte counts per organ mass were significantly higher in vaccinated SCD mice compared to their HFD counterparts, correlating with the elevated IgG titres observed in the SCD group. These results underscore the critical role of diet in shaping the immune response and vaccine efficacy. Following TBEV infection, HFD mice did not display increased disease severity or elevated viral titres in the serum, spleen or brain relative to SCD controls, indicating that obesity did not exacerbate viral replication or dissemination. However, a sex- dependent effect of obesity on the humoral immune response was observed. Male HFD mice produced antibody titres comparable to their SCD counterparts, suggesting minimal impact of obesity on their immune response. In contrast, female HFD mice exhibited significant impairments in TBEV- specific IgG and neutralizing antibody production compared to female SCD mice, as well as both male HFD and male SCD groups. These findings highlight a complex interplay between obesity, sex and immune function, with obesity disproportionately impairing the immune response after TBEV vaccination and infection.
ER  -

DVOŘÁK, Michal; Dominik ARBON; Jiří SALÁT; Andrea FOŘTOVÁ; David Pajuelo REGUERA; Tereza FRČKOVÁ; Jiří HOLOUBEK; Jana BALOUNOVA; Jan PROCHAZKA; Radislav SEDLACEK a Daniel RŮŽEK. Sex-dependent impairment of antibody responses to tick-borne encephalitis virus vaccination and infection in obese mice. \textit{JOURNAL OF GENERAL VIROLOGY}. LONDON: MICROBIOLOGY SOC, 2025, roč.~106, č.~10, s.~1-12. ISSN~0022-1317. Dostupné z: https://doi.org/10.1099/jgv.0.002161.

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