Percutaneous Endobiliary Cryobiopsy in Biliary Obstruction:
Randomised Study (BICRYOB)

J 2026

Percutaneous Endobiliary Cryobiopsy in Biliary Obstruction: Randomised Study (BICRYOB)

ROHAN, Tomáš; Barbora HANŽLOVÁ; Peter MATKULČÍK; Jakub VLAŽNÝ; Dávid SAID et al.

Základní údaje

Originální název

Percutaneous Endobiliary Cryobiopsy in Biliary Obstruction: Randomised Study (BICRYOB)

Autoři

ROHAN, Tomáš; Barbora HANŽLOVÁ; Peter MATKULČÍK; Jakub VLAŽNÝ; Dávid SAID; Marek DOSTÁL a Tomáš ANDRAŠINA

Vydání

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, NEW YORK, SPRINGER, 2026, 0174-1551

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30224 Radiology, nuclear medicine and medical imaging

Stát vydavatele

Rakousko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.900 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Cryobiopsy; Biliary obstruction; Randomised study

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 3. 2026 13:33, Mgr. Tereza Miškechová

Anotace

V originále

Design and Purpose To assess feasibility and technical outcome of endobiliary cryobiopsy compared to standard technique of endobiliary forceps biopsy in randomized study. Material and Methods This prospective study included 22 patients with indeterminate biliary stenosis. All patients underwent percutaneous endoluminal forceps biopsy and endoluminal cryobiopsy under the fluoroscopy guidance. The order of sample collection was randomized. The technical feasibility of cryobiopsy and the rate of serious complications were analyzed. Sensitivity in detecting malignancy, sample weight, total sample area, sample area without artifacts, and sample quality (five-point Likert scale) assessed by two certified pathologists were compared between both methods. Results No CTCAE (Common Terminology Criteria for Adverse Events) v.5 grade 3-4 complications were reported during or after the procedure, and cryobiopsy was technically feasible in all patients. Three of 22 patients were excluded from the analysis. A total of 232 samples were collected (112 forceps biopsy, 120 cryobiopsy). Cryobiopsy and forceps biopsy respectively detected carcinoma in 15/19 patients and 11/19 patients in total yielding positive diagnostic histology for malignancy in 79% and 58% (p = 0.11). Among the 17 patients ultimately diagnosed with malignancy, sensitivity for cryobiopsy and forceps biopsy was 88% and 65%, respectively and overall accuracy was 89% (17/19) or cryobiopsy and 68% (13/19) for forceps biopsy. Cryobiopsy provided significantly larger total and artifact-free sample areas (median 2.66 vs 0.84 mm(2) and 1.77 vs 0.18 mm(2), respectively; p < 0.001), fewer non-evaluable samples (8% vs 40%; p < 0,001), and a significantly greater median weight (7.6 vs 3.6 mg; p < 0.001). Cryobiopsy samples demonstrated markedly superior quality assessments (median Likert scale value 4 vs 2, p < 0.001; Likert > 2 in 83% vs 38%, p < 0.001). Conclusion Cryobiopsy in the biliary tract appears to be a safe and feasible technique, allowing more representative histological samples to be obtained compared with forceps biopsy.

Návaznosti

MUNI/A/1755/2024, interní kód MU

Název: Využití moderních zobrazovacích metod v rámci klinicko-radiologické korelace zánětlivých, nádorových a jiných onemocnění

Investor: Masarykova univerzita, Využití moderních zobrazovacích metod v rámci klinicko-radiologické korelace zánětlivých, nádorových a jiných onemocnění

NU21-08-00561, projekt VaV

Název: Využití ireverzibilní elektroporace a vysokofrekvenční ireverzibilní elektroporace k léčbě okluzí metalických stentů

Investor: Ministerstvo zdravotnictví ČR, Využití ireverzibilní elektroporace a vysokofrekvenční ireverzibilní elektroporace k léčbě okluzí metalických stentů, Podprogram 1 - standardní

Citovat

ROHAN, Tomáš; Barbora HANŽLOVÁ; Peter MATKULČÍK; Jakub VLAŽNÝ; Dávid SAID; Marek DOSTÁL a Tomáš ANDRAŠINA. Percutaneous Endobiliary Cryobiopsy in Biliary Obstruction: Randomised Study (BICRYOB). CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY. NEW YORK: SPRINGER, 2026, roč. 49, č. 1, s. 110-117. ISSN 0174-1551. Dostupné z: https://doi.org/10.1007/s00270-025-04282-6.

@article{2550667,
   author = {Rohan, Tomáš and Hanžlová, Barbora and Matkulčík, Peter and Vlažný, Jakub and Said, Dávid and Dostál, Marek and Andrašina, Tomáš},
   article_location = {NEW YORK},
   article_number = {1},
   doi = {https://doi.org/10.1007/s00270-025-04282-6},
   keywords = {Cryobiopsy; Biliary obstruction; Randomised study},
   language = {eng},
   issn = {0174-1551},
   journal = {CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY},
   title = {Percutaneous Endobiliary Cryobiopsy in Biliary Obstruction: Randomised Study (BICRYOB)},
   url = {https://link.springer.com/article/10.1007/s00270-025-04282-6},
   volume = {49},
   year = {2026}
}

TY  - JOUR
ID  - 2550667
AU  - Rohan, Tomáš - Hanžlová, Barbora - Matkulčík, Peter - Vlažný, Jakub - Said, Dávid - Dostál, Marek - Andrašina, Tomáš
PY  - 2026
TI  - Percutaneous Endobiliary Cryobiopsy in Biliary Obstruction: Randomised Study (BICRYOB)
JF  - CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
VL  - 49
IS  - 1
SP  - 110-117
EP  - 110-117
PB  - SPRINGER
SN  - 01741551
KW  - Cryobiopsy
KW  - Biliary obstruction
KW  - Randomised study
UR  - https://link.springer.com/article/10.1007/s00270-025-04282-6
N2  - Design and Purpose To assess feasibility and technical outcome of endobiliary cryobiopsy compared to standard technique of endobiliary forceps biopsy in randomized study. Material and Methods This prospective study included 22 patients with indeterminate biliary stenosis. All patients underwent percutaneous endoluminal forceps biopsy and endoluminal cryobiopsy under the fluoroscopy guidance. The order of sample collection was randomized. The technical feasibility of cryobiopsy and the rate of serious complications were analyzed. Sensitivity in detecting malignancy, sample weight, total sample area, sample area without artifacts, and sample quality (five-point Likert scale) assessed by two certified pathologists were compared between both methods. Results No CTCAE (Common Terminology Criteria for Adverse Events) v.5 grade 3-4 complications were reported during or after the procedure, and cryobiopsy was technically feasible in all patients. Three of 22 patients were excluded from the analysis. A total of 232 samples were collected (112 forceps biopsy, 120 cryobiopsy). Cryobiopsy and forceps biopsy respectively detected carcinoma in 15/19 patients and 11/19 patients in total yielding positive diagnostic histology for malignancy in 79% and 58% (p = 0.11). Among the 17 patients ultimately diagnosed with malignancy, sensitivity for cryobiopsy and forceps biopsy was 88% and 65%, respectively and overall accuracy was 89% (17/19) or cryobiopsy and 68% (13/19) for forceps biopsy. Cryobiopsy provided significantly larger total and artifact-free sample areas (median 2.66 vs 0.84 mm(2) and 1.77 vs 0.18 mm(2), respectively; p < 0.001), fewer non-evaluable samples (8% vs 40%; p < 0,001), and a significantly greater median weight (7.6 vs 3.6 mg; p < 0.001). Cryobiopsy samples demonstrated markedly superior quality assessments (median Likert scale value 4 vs 2, p < 0.001; Likert > 2 in 83% vs 38%, p < 0.001). Conclusion Cryobiopsy in the biliary tract appears to be a safe and feasible technique, allowing more representative histological samples to be obtained compared with forceps biopsy.
ER  -

ROHAN, Tomáš; Barbora HANŽLOVÁ; Peter MATKULČÍK; Jakub VLAŽNÝ; Dávid SAID; Marek DOSTÁL a Tomáš ANDRAŠINA. Percutaneous Endobiliary Cryobiopsy in Biliary Obstruction: Randomised Study (BICRYOB). \textit{CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY}. NEW YORK: SPRINGER, 2026, roč.~49, č.~1, s.~110-117. ISSN~0174-1551. Dostupné z: https://doi.org/10.1007/s00270-025-04282-6.

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