Total pancreatectomy with Langerhans islets autotransplantation
for pancreatico-pleural fistula 2 years after
pancreatoduodenectomy for chronic pancreatitis

J 2025

Total pancreatectomy with Langerhans islets autotransplantation for pancreatico-pleural fistula 2 years after pancreatoduodenectomy for chronic pancreatitis

HLAVSA, Jan; Petr MORAVČÍK; Peter GIRMAN; Jakub CSÖLLE; David MAREK et al.

Základní údaje

Originální název

Total pancreatectomy with Langerhans islets autotransplantation for pancreatico-pleural fistula 2 years after pancreatoduodenectomy for chronic pancreatitis

Autoři

Vydání

Rozhledy v chirurgii, Praha, Česká lékařská společnost J.E. Purkyně, 2025, 0035-9351

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30212 Surgery

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00143572

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.48095/ccrvch2025404

EID Scopus

2-s2.0-105019113580

Klíčová slova anglicky

fistula; chronic pancreatitis; autotransplantation; Langerhans islet

Štítky

rivok

Změněno: 24. 3. 2026 14:58, Mgr. Tereza Miškechová

Anotace

V originále

Introduction: Pancreaticopleural fistula (PPF) represents a rare complication of chronic pancreatitis. The treatment is complex including pleural drainage, decompression of main pancreatic duct by endoscopic retrograde cholangiopancreatography, pancreas rest with parenteral or enteral nutrition via naso-jejunal feeding tube and somatostatin analogues application. Surgery is indicated when the conservative or endoscopic treatment is not successful. In selected cases, total pancreatectomy may be considered. After these procedures, unstable diabetes mellitus may be a problem. In this case report, the authors present an alternative way to resolve pancreatico-pleural fistula in patients with a history of pancreatic resection. Case report: A 49-year-old man underwent pancreatoduodenectomy with pancreato-gastrostomy for chronic pancreatitis in 2018. Two years after the procedure, he had severe dyspnea, with X-ray showing left-sided fluidothorax. Pleuracentesis confirmed high amylase activity in pleural effusion. A CT scan was performed and a diagnosis of pancreaticopleural fistula was made. Due to the failure of conservative treatment, the residual pancreas was resected. The islets of Langerhans from the resected pancreatic tissue were isolated and transplanted back into the patient’s liver via the portal vein. The postoperative course was uneventful. Two year after the procedure, the patient was asymptomatic without pleural effusion recurrence and no need of insulin replacement therapy. Conclusion: Total pancreatectomy with islet autotransplantation may be an appropriate method of treatment for recurrent pancreaticopleural fistula in situations where less radical procedures are not possible.

Návaznosti

LX22NPO5104, projekt VaV

Název: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění (Akronym: CarDia)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní institut pro léčbu metabolických a kardiovaskulárních onemocnění, 5.1 EXCELES

Citovat

HLAVSA, Jan; Petr MORAVČÍK; Peter GIRMAN; Jakub CSÖLLE; David MAREK; Radek KROUPA; Milan DASTYCH; Tomáš ANDRAŠINA; Jana BĚLOBRÁDKOVÁ; Jan KŘÍŽ; Zuzana BERKOVÁ; Ivan LEONTOVYČ; Vladimír PROCHÁZKA a Zdeněk KALA. Total pancreatectomy with Langerhans islets autotransplantation for pancreatico-pleural fistula 2 years after pancreatoduodenectomy for chronic pancreatitis. Rozhledy v chirurgii. Praha: Česká lékařská společnost J.E. Purkyně, 2025, roč. 104, č. 9, s. 404-408. ISSN 0035-9351. Dostupné z: https://doi.org/10.48095/ccrvch2025404.

@article{2550690,
   author = {Hlavsa, Jan and Moravčík, Petr and Girman, Peter and Csölle, Jakub and Marek, David and Kroupa, Radek and Dastych, Milan and Andrašina, Tomáš and Bělobrádková, Jana and Kříž, Jan and Berková, Zuzana and Leontovyč, Ivan and Procházka, Vladimír and Kala, Zdeněk},
   article_location = {Praha},
   article_number = {9},
   doi = {https://doi.org/10.48095/ccrvch2025404},
   keywords = {fistula; chronic pancreatitis; autotransplantation; Langerhans islet},
   language = {eng},
   issn = {0035-9351},
   journal = {Rozhledy v chirurgii},
   title = {Total pancreatectomy with Langerhans islets autotransplantation for pancreatico-pleural fistula 2 years after pancreatoduodenectomy for chronic pancreatitis},
   url = {https://www.perspinsurg.com/rvch/article/view/1141},
   volume = {104},
   year = {2025}
}

TY  - JOUR
ID  - 2550690
AU  - Hlavsa, Jan - Moravčík, Petr - Girman, Peter - Csölle, Jakub - Marek, David - Kroupa, Radek - Dastych, Milan - Andrašina, Tomáš - Bělobrádková, Jana - Kříž, Jan - Berková, Zuzana - Leontovyč, Ivan - Procházka, Vladimír - Kala, Zdeněk
PY  - 2025
TI  - Total pancreatectomy with Langerhans islets autotransplantation for pancreatico-pleural fistula 2 years after pancreatoduodenectomy for chronic pancreatitis
JF  - Rozhledy v chirurgii
VL  - 104
IS  - 9
SP  - 404-408
EP  - 404-408
PB  - Česká lékařská společnost J.E. Purkyně
SN  - 00359351
KW  - fistula
KW  - chronic pancreatitis
KW  - autotransplantation
KW  - Langerhans islet
UR  - https://www.perspinsurg.com/rvch/article/view/1141
N2  - Introduction: Pancreaticopleural fistula (PPF) represents a rare complication of chronic pancreatitis. The treatment is complex including pleural drainage, decompression of main pancreatic duct by endoscopic retrograde cholangiopancreatography, pancreas rest with parenteral or enteral nutrition via naso-jejunal feeding tube and somatostatin analogues application. Surgery is indicated when the conservative or endoscopic treatment is not successful. In selected cases, total pancreatectomy may be considered. After these procedures, unstable diabetes mellitus may be a problem. In this case report, the authors present an alternative way to resolve pancreatico-pleural fistula in patients with a history of pancreatic resection. Case report: A 49-year-old man underwent pancreatoduodenectomy with pancreato-gastrostomy for chronic pancreatitis in 2018. Two years after the procedure, he had severe dyspnea, with X-ray showing left-sided fluidothorax. Pleuracentesis confirmed high amylase activity in pleural effusion. A CT scan was performed and a diagnosis of pancreaticopleural fistula was made. Due to the failure of conservative treatment, the residual pancreas was resected. The islets of Langerhans from the resected pancreatic tissue were isolated and transplanted back into the patient’s liver via the portal vein. The postoperative course was uneventful. Two year after the procedure, the patient was asymptomatic without pleural effusion recurrence and no need of insulin replacement therapy. Conclusion: Total pancreatectomy with islet autotransplantation may be an appropriate method of treatment for recurrent pancreaticopleural fistula in situations where less radical procedures are not possible.
ER  -

HLAVSA, Jan; Petr MORAVČÍK; Peter GIRMAN; Jakub CSÖLLE; David MAREK; Radek KROUPA; Milan DASTYCH; Tomáš ANDRAŠINA; Jana BĚLOBRÁDKOVÁ; Jan KŘÍŽ; Zuzana BERKOVÁ; Ivan LEONTOVYČ; Vladimír PROCHÁZKA a Zdeněk KALA. Total pancreatectomy with Langerhans islets autotransplantation for pancreatico-pleural fistula 2 years after pancreatoduodenectomy for chronic pancreatitis. \textit{Rozhledy v chirurgii}. Praha: Česká lékařská společnost J.E. Purkyně, 2025, roč.~104, č.~9, s.~404-408. ISSN~0035-9351. Dostupné z: https://doi.org/10.48095/ccrvch2025404.

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