Multi-Target Modulation of Polyphenols in Diabetic Kidney
Disease Therapeutics: A Comprehensive Review

J 2025

Multi-Target Modulation of Polyphenols in Diabetic Kidney Disease Therapeutics: A Comprehensive Review

EFIONG, Esienanwan E.; Emmanuel EFFA; Esther PETERS; Ochuko L. ERUKAINURE; Peter U. AMADI et al.

Základní údaje

Originální název

Multi-Target Modulation of Polyphenols in Diabetic Kidney Disease Therapeutics: A Comprehensive Review

Autoři

EFIONG, Esienanwan E.; Emmanuel EFFA; Esther PETERS; Ochuko L. ERUKAINURE; Peter U. AMADI; Joshua Onyeka IKEBUIRO; Sapna SHARMA; Christoph SCHMADERER; Kathrin MAEDLER; Emmy TUENTER a Harald GRALLERT

Vydání

Food Science & Nutrition, WILEY, 2025, 2048-7177

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30300 3.3 Health sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.800 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/25:00143596

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

diabetes mellitus; diabetic nephropathy; end-stage kidney disease; kidney replacement therapy; microvascular complication; phytochemistry

Štítky

14314010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 2. 2026 09:20, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Diabetic kidney disease (DKD) is a severe complication of diabetes that presents as progressive kidney dysfunction and is the primary cause of end-stage kidney failure. Despite therapeutic advances, including the use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, sodium-glucose co-transporter-2 inhibitors, glucagon-like peptide-1 agonists, and non-steroidal mineralocorticoid receptor antagonists, managing DKD remains challenging. Current therapies mainly focus on glycemic control, hypertension management, and albumin reduction to mitigate kidney damage. Nevertheless, these approaches often fail to halt disease progression or restore renal function. There is therefore an urgent need for therapies with safer profiles that can be used singly to target the disease's underlying pathophysiology or integrated into traditional care. Polyphenols possess biological properties capable of addressing these unmet needs by targeting multiple underlying mechanisms involved in DKD pathogenesis. The literature search occurred between September 2024 and April 2025, with most articles sourced from the last 5 years. This review explores polyphenol classes that have demonstrated nephroprotective effects in vitro, in vivo, and in clinical trials. It also highlights the interconnected multi-pathways and molecular mediators potentially regulated by specific polyphenols for kidney function improvement. This multi-target therapeutic approach is especially beneficial for DKD, where several metabolic dysfunctions underlie its pathogenesis. Identifying polyphenols as a therapeutic option could lead to integrative patient care that embraces the strengths of conventional medicine and phytomedicine for better disease management and outcomes. There is therefore a need for more clinical trials to assess polyphenols' safety and efficacy in managing DKD.

Citovat

EFIONG, Esienanwan E.; Emmanuel EFFA; Esther PETERS; Ochuko L. ERUKAINURE; Peter U. AMADI; Joshua Onyeka IKEBUIRO; Sapna SHARMA; Christoph SCHMADERER; Kathrin MAEDLER; Emmy TUENTER a Harald GRALLERT. Multi-Target Modulation of Polyphenols in Diabetic Kidney Disease Therapeutics: A Comprehensive Review. Food Science & Nutrition. WILEY, 2025, roč. 13, č. 10, s. 1-23. ISSN 2048-7177. Dostupné z: https://doi.org/10.1002/fsn3.70882.

@article{2551061,
   author = {Efiong, Esienanwan E. and Effa, Emmanuel and Peters, Esther and Erukainure, Ochuko L. and Amadi, Peter U. and Ikebuiro, Joshua Onyeka and Sharma, Sapna and Schmaderer, Christoph and Maedler, Kathrin and Tuenter, Emmy and Grallert, Harald},
   article_number = {10},
   doi = {https://doi.org/10.1002/fsn3.70882},
   keywords = {diabetes mellitus; diabetic nephropathy; end-stage kidney disease; kidney replacement therapy; microvascular complication; phytochemistry},
   language = {eng},
   issn = {2048-7177},
   journal = {Food Science & Nutrition},
   title = {Multi-Target Modulation of Polyphenols in Diabetic Kidney Disease Therapeutics: A Comprehensive Review},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/fsn3.70882},
   volume = {13},
   year = {2025}
}

TY  - JOUR
ID  - 2551061
AU  - Efiong, Esienanwan E. - Effa, Emmanuel - Peters, Esther - Erukainure, Ochuko L. - Amadi, Peter U. - Ikebuiro, Joshua Onyeka - Sharma, Sapna - Schmaderer, Christoph - Maedler, Kathrin - Tuenter, Emmy - Grallert, Harald
PY  - 2025
TI  - Multi-Target Modulation of Polyphenols in Diabetic Kidney Disease Therapeutics: A Comprehensive Review
JF  - Food Science & Nutrition
VL  - 13
IS  - 10
SP  - 1-23
EP  - 1-23
PB  - WILEY
SN  - 20487177
KW  - diabetes mellitus
KW  - diabetic nephropathy
KW  - end-stage kidney disease
KW  - kidney replacement therapy
KW  - microvascular complication
KW  - phytochemistry
UR  - https://onlinelibrary.wiley.com/doi/10.1002/fsn3.70882
N2  - Diabetic kidney disease (DKD) is a severe complication of diabetes that presents as progressive kidney dysfunction and is the primary cause of end-stage kidney failure. Despite therapeutic advances, including the use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, sodium-glucose co-transporter-2 inhibitors, glucagon-like peptide-1 agonists, and non-steroidal mineralocorticoid receptor antagonists, managing DKD remains challenging. Current therapies mainly focus on glycemic control, hypertension management, and albumin reduction to mitigate kidney damage. Nevertheless, these approaches often fail to halt disease progression or restore renal function. There is therefore an urgent need for therapies with safer profiles that can be used singly to target the disease's underlying pathophysiology or integrated into traditional care. Polyphenols possess biological properties capable of addressing these unmet needs by targeting multiple underlying mechanisms involved in DKD pathogenesis. The literature search occurred between September 2024 and April 2025, with most articles sourced from the last 5 years. This review explores polyphenol classes that have demonstrated nephroprotective effects in vitro, in vivo, and in clinical trials. It also highlights the interconnected multi-pathways and molecular mediators potentially regulated by specific polyphenols for kidney function improvement. This multi-target therapeutic approach is especially beneficial for DKD, where several metabolic dysfunctions underlie its pathogenesis. Identifying polyphenols as a therapeutic option could lead to integrative patient care that embraces the strengths of conventional medicine and phytomedicine for better disease management and outcomes. There is therefore a need for more clinical trials to assess polyphenols' safety and efficacy in managing DKD.
ER  -

EFIONG, Esienanwan E.; Emmanuel EFFA; Esther PETERS; Ochuko L. ERUKAINURE; Peter U. AMADI; Joshua Onyeka IKEBUIRO; Sapna SHARMA; Christoph SCHMADERER; Kathrin MAEDLER; Emmy TUENTER a Harald GRALLERT. Multi-Target Modulation of Polyphenols in Diabetic Kidney Disease Therapeutics: A Comprehensive Review. \textit{Food Science \&{} Nutrition}. WILEY, 2025, roč.~13, č.~10, s.~1-23. ISSN~2048-7177. Dostupné z: https://doi.org/10.1002/fsn3.70882.

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