Primary bile acid shapes peripheral immunity in inflammatory
bowel disease-associated primary sclerosing cholangitis

J 2025

Primary bile acid shapes peripheral immunity in inflammatory bowel disease-associated primary sclerosing cholangitis

SANTOS, Andre A.; David PIRES; Vanda MARQUES; Nicole ALESINA; Elisa HERRAEZ et al.

Základní údaje

Originální název

Primary bile acid shapes peripheral immunity in inflammatory bowel disease-associated primary sclerosing cholangitis

Autoři

Vydání

CLINICAL SCIENCE, ENGLAND, PORTLAND PRESS LTD, 2025, 0143-5221

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30219 Gastroenterology and hepatology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.700 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

7-ALPHA-HYDROXY-4-CHOLESTEN-3-ONE; macrophages; microbiota; serum; IBD

Štítky

CF PROT, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 3. 2026 08:23, Mgr. Eva Dubská

Anotace

V originále

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease often associated with underlying inflammatory bowel disease (IBD). This study investigates how PSC predisposes individuals to altered inflammatory immune responses compared with IBD alone. A case–control study was conducted with a cohort of 75 patients, including 16 with PSC (14 with concomitant IBD), 39 with IBD alone, and 20 controls. Serum bile acid profile, proteomic analysis, and immune-related gene expression in the colon tissue were examined. Colonic tissue from PSC patients exhibited up-regulation of immune regulation and inflammatory signaling mRNA markers, including LGR5, IL-8, CCL2, COX2, TWIST1, and SNAIL. Additionally, PSC patients displayed a distinct proinflammatory serum proteomic signature and moderate elevation of some bile acids, such as glycochenodeoxycholic acid (GCDCA). Co-incubation of human-derived monocytes with GCDCA partially replicated the inflammatory profile observed in PSC. These findings suggest that circulating bile acids modulate the peripheral immune system proinflammatory response, contributing to the unique PSC phenotype.

Návaznosti

90242, velká výzkumná infrastruktura

Název: CIISB III

90254, velká výzkumná infrastruktura

Název: e-INFRA CZ II

Citovat

SANTOS, Andre A.; David PIRES; Vanda MARQUES; Nicole ALESINA; Elisa HERRAEZ; Pavel ROUDNICKÝ; Pedro M. RODRIGUES; Ana GODINHO-SANTOS; Ana Catarina BRAVO; Catarina GOUVEIA; Susana SARAIVA; Luis CORREIA; Ricardo CRESPO; Joao Pereira DA SILVA; Marilia CRAVO; David POTĚŠIL; Zbyněk ZDRÁHAL; Jesus M. BANALES; Jose J. G. MARIN; Joana TORRES a Cecilia M. P. RODRIGUES. Primary bile acid shapes peripheral immunity in inflammatory bowel disease-associated primary sclerosing cholangitis. CLINICAL SCIENCE. ENGLAND: PORTLAND PRESS LTD, 2025, roč. 139, č. 12, s. 703-716. ISSN 0143-5221. Dostupné z: https://doi.org/10.1042/CS20256078.

@article{2551082,
   author = {Santos, Andre A. and Pires, David and Marques, Vanda and Alesina, Nicole and Herraez, Elisa and Roudnický, Pavel and Rodrigues, Pedro M. and GodinhoandSantos, Ana and Bravo, Ana Catarina and Gouveia, Catarina and Saraiva, Susana and Correia, Luis and Crespo, Ricardo and da Silva, Joao Pereira and Cravo, Marilia and Potěšil, David and Zdráhal, Zbyněk and Banales, Jesus M. and Marin, Jose J. G. and Torres, Joana and Rodrigues, Cecilia M. P.},
   article_location = {ENGLAND},
   article_number = {12},
   doi = {https://doi.org/10.1042/CS20256078},
   keywords = {7-ALPHA-HYDROXY-4-CHOLESTEN-3-ONE; macrophages; microbiota; serum; IBD},
   language = {eng},
   issn = {0143-5221},
   journal = {CLINICAL SCIENCE},
   title = {Primary bile acid shapes peripheral immunity in inflammatory bowel disease-associated primary sclerosing cholangitis},
   url = {https://portlandpress.com/clinsci/article/139/12/703/236163/Primary-bile-acid-shapes-peripheral-immunity-in},
   volume = {139},
   year = {2025}
}

TY  - JOUR
ID  - 2551082
AU  - Santos, Andre A. - Pires, David - Marques, Vanda - Alesina, Nicole - Herraez, Elisa - Roudnický, Pavel - Rodrigues, Pedro M. - Godinho-Santos, Ana - Bravo, Ana Catarina - Gouveia, Catarina - Saraiva, Susana - Correia, Luis - Crespo, Ricardo - da Silva, Joao Pereira - Cravo, Marilia - Potěšil, David - Zdráhal, Zbyněk - Banales, Jesus M. - Marin, Jose J. G. - Torres, Joana - Rodrigues, Cecilia M. P.
PY  - 2025
TI  - Primary bile acid shapes peripheral immunity in inflammatory bowel disease-associated primary sclerosing cholangitis
JF  - CLINICAL SCIENCE
VL  - 139
IS  - 12
SP  - 703-716
EP  - 703-716
PB  - PORTLAND PRESS LTD
SN  - 01435221
KW  - 7-ALPHA-HYDROXY-4-CHOLESTEN-3-ONE
KW  - macrophages
KW  - microbiota
KW  - serum
KW  - IBD
UR  - https://portlandpress.com/clinsci/article/139/12/703/236163/Primary-bile-acid-shapes-peripheral-immunity-in
N2  - Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease often associated with underlying inflammatory bowel disease (IBD). This study investigates how PSC predisposes individuals to altered inflammatory immune responses compared with IBD alone. A case–control study was conducted with a cohort of 75 patients, including 16 with PSC (14 with concomitant IBD), 39 with IBD alone, and 20 controls. Serum bile acid profile, proteomic analysis, and immune-related gene expression in the colon tissue were examined. Colonic tissue from PSC patients exhibited up-regulation of immune regulation and inflammatory signaling mRNA markers, including LGR5, IL-8, CCL2, COX2, TWIST1, and SNAIL. Additionally, PSC patients displayed a distinct proinflammatory serum proteomic signature and moderate elevation of some bile acids, such as glycochenodeoxycholic acid (GCDCA). Co-incubation of human-derived monocytes with GCDCA partially replicated the inflammatory profile observed in PSC. These findings suggest that circulating bile acids modulate the peripheral immune system proinflammatory response, contributing to the unique PSC phenotype.
ER  -

SANTOS, Andre A.; David PIRES; Vanda MARQUES; Nicole ALESINA; Elisa HERRAEZ; Pavel ROUDNICKÝ; Pedro M. RODRIGUES; Ana GODINHO-SANTOS; Ana Catarina BRAVO; Catarina GOUVEIA; Susana SARAIVA; Luis CORREIA; Ricardo CRESPO; Joao Pereira DA SILVA; Marilia CRAVO; David POTĚŠIL; Zbyněk ZDRÁHAL; Jesus M. BANALES; Jose J. G. MARIN; Joana TORRES a Cecilia M. P. RODRIGUES. Primary bile acid shapes peripheral immunity in inflammatory bowel disease-associated primary sclerosing cholangitis. \textit{CLINICAL SCIENCE}. ENGLAND: PORTLAND PRESS LTD, 2025, roč.~139, č.~12, s.~703-716. ISSN~0143-5221. Dostupné z: https://doi.org/10.1042/CS20256078.

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