Risk factors for cleft lip and palate in the Czech population -
a double center study

J 2025

Risk factors for cleft lip and palate in the Czech population - a double center study

URBANOVÁ, Wanda; M. VEČEŘOVÁ; Jitka VOKURKOVÁ; Libor STREIT; J. VAŠÁKOVÁ et al.

Základní údaje

Originální název

Risk factors for cleft lip and palate in the Czech population - a double center study

Autoři

URBANOVÁ, Wanda; M. VEČEŘOVÁ; Jitka VOKURKOVÁ; Libor STREIT; J. VAŠÁKOVÁ; A. LEGER a Olga KOŠKOVÁ

Vydání

Acta Chirurgiae Plasticae, Praha, Czech Medical Association J.E. Purkyne, 2025, 0001-5423

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30212 Surgery

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.48095/ccachp202592

EID Scopus

2-s2.0-105016522550

Klíčová slova anglicky

BMI; cleft lip and palate; cleft palate only; cleft severity; orofacial clefts; prenatal diagnosis; risk factors

Štítky

rivok

Příznaky

Recenzováno

Změněno: 17. 3. 2026 12:54, Mgr. Tereza Miškechová

Anotace

V originále

Background: Orofacial clefts (OFC) are common congenital anomalies with complex genetic and environmental etiologies. Although multiple risk factors have been suggested, their role in cleft type and severity remains unclear. Objective: This study aimed to assess the relationship between environmental and maternal health factors (body mass index – BMI, parental age, infection, stress, prenatal vitamin supplementation) and the occurrence and severity of cleft types in the Czech population, as well as the effectiveness of prenatal diagnosis by ultrasound. Methods: A total of 96 parents of children with nonsyndromic OFC born between 2017 and 2024 in the Czech Republic were surveyed using a custom online questionnaire (RoRis). The data were analyzed using Fisher’s exact test (α = 0.05). Results: The distribution of cleft types in this Czech sample was consistent with international data. Prenatal diagnosis by ultrasound was established in 55% of cases. The highest detection rates were observed for bilateral cleft lip and palate, with 100% of cases diagnosed prenatally, and for unilateral cleft lip and palate, with a 93% detection rate. In contrast, cleft palate only (CPO) was the most frequently missed, with 88% of cases undetected. No significant associations were found neither between the cleft type nor the severity of clefts and parental age, maternal BMI, medication use, infection with fever, or stress during pregnancy. Most mothers had a normal BMI (51%), and 85% reported prenatal supplement use. COVID-19 infection during pregnancy was reported in 13 cases, but no clear link with cleft severity was found. Conclusion: While several exogenous factors were studied, no significant associations neither with cleft type nor severity were found. The study highlights the limitations of prenatal screening diagnosis by ultrasound, particularly for CPO, and supports the need for further research into modifiable risk factors. © 2025, Czech Medical Association J.E. Purkyne. All rights reserved.

Návaznosti

MUNI/A/1782/2024, interní kód MU

Název: Inovace v popáleninové medicíně a rekonstrukční plastické chirurgii II

Investor: Masarykova univerzita, Inovace v popáleninové medicíně a rekonstrukční plastické chirurgii II

Citovat

URBANOVÁ, Wanda; M. VEČEŘOVÁ; Jitka VOKURKOVÁ; Libor STREIT; J. VAŠÁKOVÁ; A. LEGER a Olga KOŠKOVÁ. Risk factors for cleft lip and palate in the Czech population - a double center study. Acta Chirurgiae Plasticae. Praha: Czech Medical Association J.E. Purkyne, 2025, roč. 67, č. 2, s. 92-97. ISSN 0001-5423. Dostupné z: https://doi.org/10.48095/ccachp202592.

@article{2551095,
   author = {Urbanová, Wanda and Večeřová, M. and Vokurková, Jitka and Streit, Libor and Vašáková, J. and Leger, A. and Košková, Olga},
   article_location = {Praha},
   article_number = {2},
   doi = {https://doi.org/10.48095/ccachp202592},
   keywords = {BMI; cleft lip and palate; cleft palate only; cleft severity; orofacial clefts; prenatal diagnosis; risk factors},
   language = {eng},
   issn = {0001-5423},
   journal = {Acta Chirurgiae Plasticae},
   title = {Risk factors for cleft lip and palate in the Czech population - a double center study},
   url = {https://acta-chirurgiae-plasticae.com/wp-content/uploads/2025/09/ACHP_2025_2-urbanova.pdf},
   volume = {67},
   year = {2025}
}

TY  - JOUR
ID  - 2551095
AU  - Urbanová, Wanda - Večeřová, M. - Vokurková, Jitka - Streit, Libor - Vašáková, J. - Leger, A. - Košková, Olga
PY  - 2025
TI  - Risk factors for cleft lip and palate in the Czech population - a double center study
JF  - Acta Chirurgiae Plasticae
VL  - 67
IS  - 2
SP  - 92-97
EP  - 92-97
PB  - Czech Medical Association J.E. Purkyne
SN  - 00015423
KW  - BMI
KW  - cleft lip and palate
KW  - cleft palate only
KW  - cleft severity
KW  - orofacial clefts
KW  - prenatal diagnosis
KW  - risk factors
UR  - https://acta-chirurgiae-plasticae.com/wp-content/uploads/2025/09/ACHP_2025_2-urbanova.pdf
N2  - Background: Orofacial clefts (OFC) are common congenital anomalies with complex genetic and environmental etiologies. Although multiple risk factors have been suggested, their role in cleft type and severity remains unclear. Objective: This study aimed to assess the relationship between environmental and maternal health factors (body mass index – BMI, parental age, infection, stress, prenatal vitamin supplementation) and the occurrence and severity of cleft types in the Czech population, as well as the effectiveness of prenatal diagnosis by ultrasound. Methods: A total of 96 parents of children with nonsyndromic OFC born between 2017 and 2024 in the Czech Republic were surveyed using a custom online questionnaire (RoRis). The data were analyzed using Fisher’s exact test (α = 0.05). Results: The distribution of cleft types in this Czech sample was consistent with international data. Prenatal diagnosis by ultrasound was established in 55% of cases. The highest detection rates were observed for bilateral cleft lip and palate, with 100% of cases diagnosed prenatally, and for unilateral cleft lip and palate, with a 93% detection rate. In contrast, cleft palate only (CPO) was the most frequently missed, with 88% of cases undetected. No significant associations were found neither between the cleft type nor the severity of clefts and parental age, maternal BMI, medication use, infection with fever, or stress during pregnancy. Most mothers had a normal BMI (51%), and 85% reported prenatal supplement use. COVID-19 infection during pregnancy was reported in 13 cases, but no clear link with cleft severity was found. Conclusion: While several exogenous factors were studied, no significant associations neither with cleft type nor severity were found. The study highlights the limitations of prenatal screening diagnosis by ultrasound, particularly for CPO, and supports the need for further research into modifiable risk factors. © 2025, Czech Medical Association J.E. Purkyne. All rights reserved.
ER  -

URBANOVÁ, Wanda; M. VEČEŘOVÁ; Jitka VOKURKOVÁ; Libor STREIT; J. VAŠÁKOVÁ; A. LEGER a Olga KOŠKOVÁ. Risk factors for cleft lip and palate in the Czech population - a double center study. \textit{Acta Chirurgiae Plasticae}. Praha: Czech Medical Association J.E. Purkyne, 2025, roč.~67, č.~2, s.~92-97. ISSN~0001-5423. Dostupné z: https://doi.org/10.48095/ccachp202592.

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