Fertility preservation practices and gastrointestinal
oncologist in Europe: a pan-European study

J 2025

Fertility preservation practices and gastrointestinal oncologist in Europe: a pan-European study

BEN-AHARON, Irit; Tal GOSHEN-LAGO; Alberto PUCCINI; Maria ALSINA; Dirk ARNOLD et al.

Základní údaje

Originální název

Fertility preservation practices and gastrointestinal oncologist in Europe: a pan-European study

Autoři

Vydání

Oncologist, OXFORD, OXFORD UNIV PRESS, 2025, 1083-7159

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.200 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

fertility preservation; gastrointestinal cancer; oncofertility; young adult cancer patients; European oncology practices

Štítky

14110811, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 3. 2026 10:18, Mgr. Tereza Miškechová

Anotace

V originále

Introduction: The rising incidence of early-onset gastrointestinal (GI) cancer has made the impact of treatments on fertility of high significance. While there is abundant evidence on oncofertility outcomes in breast cancer and hematological malignancies, data regarding these perspectives in GI cancers is lacking. We sought to evaluate current practices of fertility preservation (FP) among GI oncologists across Europe. Methods: A cross-sectional survey was distributed through the Gastrointestinal Tract Cancer Group (GITCG) of the EORTC network and affiliated cooperative groups and cancer centers using a 10-item electronic survey regarding oncofertility practices. The target population was oncologists who routinely treat GI cancers. A statistical analysis was performed based on country, patient volume, and tumor type. Results: Two hundred and twenty-six GI oncologists from 27 countries completed the survey, the majority from high volume cancer centers. Fifty seven percent of the participating oncologists routinely discuss the impact of treatment on fertility in any patient <40 years, while 36% discuss this only in the curative setting. Fifty-nine percent refer female patients to standard FP options (embryo/oocyte preservation), while 24% chose to refer to ovarian cryopreservation. Of note, 17% indicated they would not refer a curative patient for FP at all due to time or resource issues. Sixty five percent routinely refer male patients to sperm preservation. Use of Gonadotropin Releasing Hormone analogues (GnRHa) in CRC patients is recommended by 34% of oncologists. In the setting of pelvic radiation, 65% refer a female patient for ovarian transposition before pelvic irradiation; 32% would consider uterine transposition. Sixty one percent would consider a nonradiation protocol as perioperative chemotherapy as a valid option for young female patients. We observed heterogeneity upon country but not upon physician gender. Conclusion: Our study indicates a substantial diversity in current practices in Europe with regard to FP in young cancer patients with GI malignancies, which is not always aligned with current guidelines. There is a need to disseminate and educate GI oncologists on oncofertility perspectives and contemporary data. Additionally, there is a need to establish evidence on the utility of fertility preservation options for patients with GI cancers.

Citovat

BEN-AHARON, Irit; Tal GOSHEN-LAGO; Alberto PUCCINI; Maria ALSINA; Dirk ARNOLD; Van Laarhoven HANNEKE; Anneli ELME; Tineke BUFFART; Nina FOKTER-DOVNIK; Tomáš SOKOP; Radka LORDICK OBERMANNOVÁ; Florian LORDICK; Demetris PAPAMICHAEL; Francesco SCLAFANI; Elena ELEZ a Julien TAIEB. Fertility preservation practices and gastrointestinal oncologist in Europe: a pan-European study. Oncologist. OXFORD: OXFORD UNIV PRESS, 2025, roč. 30, č. 11, s. 1-8. ISSN 1083-7159. Dostupné z: https://doi.org/10.1093/oncolo/oyaf350.

@article{2551518,
   author = {BenandAharon, Irit and GoshenandLago, Tal and Puccini, Alberto and Alsina, Maria and Arnold, Dirk and Hanneke, Van Laarhoven and Elme, Anneli and Buffart, Tineke and FokterandDovnik, Nina and Sokop, Tomáš and Lordick Obermannová, Radka and Lordick, Florian and Papamichael, Demetris and Sclafani, Francesco and Elez, Elena and Taieb, Julien},
   article_location = {OXFORD},
   article_number = {11},
   doi = {https://doi.org/10.1093/oncolo/oyaf350},
   keywords = {fertility preservation; gastrointestinal cancer; oncofertility; young adult cancer patients; European oncology practices},
   language = {eng},
   issn = {1083-7159},
   journal = {Oncologist},
   title = {Fertility preservation practices and gastrointestinal oncologist in Europe: a pan-European study},
   url = {https://academic.oup.com/oncolo/article/30/11/oyaf350/8315003},
   volume = {30},
   year = {2025}
}

TY  - JOUR
ID  - 2551518
AU  - Ben-Aharon, Irit - Goshen-Lago, Tal - Puccini, Alberto - Alsina, Maria - Arnold, Dirk - Hanneke, Van Laarhoven - Elme, Anneli - Buffart, Tineke - Fokter-Dovnik, Nina - Sokop, Tomáš - Lordick Obermannová, Radka - Lordick, Florian - Papamichael, Demetris - Sclafani, Francesco - Elez, Elena - Taieb, Julien
PY  - 2025
TI  - Fertility preservation practices and gastrointestinal oncologist in Europe: a pan-European study
JF  - Oncologist
VL  - 30
IS  - 11
SP  - 1-8
EP  - 1-8
PB  - OXFORD UNIV PRESS
SN  - 10837159
KW  - fertility preservation
KW  - gastrointestinal cancer
KW  - oncofertility
KW  - young adult cancer patients
KW  - European oncology practices
UR  - https://academic.oup.com/oncolo/article/30/11/oyaf350/8315003
N2  - Introduction: The rising incidence of early-onset gastrointestinal (GI) cancer has made the impact of treatments on fertility of high significance. While there is abundant evidence on oncofertility outcomes in breast cancer and hematological malignancies, data regarding these perspectives in GI cancers is lacking. We sought to evaluate current practices of fertility preservation (FP) among GI oncologists across Europe. Methods: A cross-sectional survey was distributed through the Gastrointestinal Tract Cancer Group (GITCG) of the EORTC network and affiliated cooperative groups and cancer centers using a 10-item electronic survey regarding oncofertility practices. The target population was oncologists who routinely treat GI cancers. A statistical analysis was performed based on country, patient volume, and tumor type. Results: Two hundred and twenty-six GI oncologists from 27 countries completed the survey, the majority from high volume cancer centers. Fifty seven percent of the participating oncologists routinely discuss the impact of treatment on fertility in any patient <40 years, while 36% discuss this only in the curative setting. Fifty-nine percent refer female patients to standard FP options (embryo/oocyte preservation), while 24% chose to refer to ovarian cryopreservation. Of note, 17% indicated they would not refer a curative patient for FP at all due to time or resource issues. Sixty five percent routinely refer male patients to sperm preservation. Use of Gonadotropin Releasing Hormone analogues (GnRHa) in CRC patients is recommended by 34% of oncologists. In the setting of pelvic radiation, 65% refer a female patient for ovarian transposition before pelvic irradiation; 32% would consider uterine transposition. Sixty one percent would consider a nonradiation protocol as perioperative chemotherapy as a valid option for young female patients. We observed heterogeneity upon country but not upon physician gender. Conclusion: Our study indicates a substantial diversity in current practices in Europe with regard to FP in young cancer patients with GI malignancies, which is not always aligned with current guidelines. There is a need to disseminate and educate GI oncologists on oncofertility perspectives and contemporary data. Additionally, there is a need to establish evidence on the utility of fertility preservation options for patients with GI cancers.
ER  -

BEN-AHARON, Irit; Tal GOSHEN-LAGO; Alberto PUCCINI; Maria ALSINA; Dirk ARNOLD; Van Laarhoven HANNEKE; Anneli ELME; Tineke BUFFART; Nina FOKTER-DOVNIK; Tomáš SOKOP; Radka LORDICK OBERMANNOVÁ; Florian LORDICK; Demetris PAPAMICHAEL; Francesco SCLAFANI; Elena ELEZ a Julien TAIEB. Fertility preservation practices and gastrointestinal oncologist in Europe: a pan-European study. \textit{Oncologist}. OXFORD: OXFORD UNIV PRESS, 2025, roč.~30, č.~11, s.~1-8. ISSN~1083-7159. Dostupné z: https://doi.org/10.1093/oncolo/oyaf350.

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