Spatiotemporal brain complexity quantifies consciousness
outside of perturbation paradigms

J 2025

Spatiotemporal brain complexity quantifies consciousness outside of perturbation paradigms

BREYTON, Martin; Jan FOUSEK; Giovanni RABUFFO; Pierpaolo SORRENTINO; Lionel KUSCH et al.

Základní údaje

Originální název

Spatiotemporal brain complexity quantifies consciousness outside of perturbation paradigms

Autoři

BREYTON, Martin; Jan FOUSEK ; Giovanni RABUFFO; Pierpaolo SORRENTINO; Lionel KUSCH; Marcello MASSIMINI; Spase PETKOSKI a Viktor JIRSA

Vydání

elife, CAMBRIDGE, ELIFE SCIENCES PUBLICATIONS LTD, 2025, 2050-084X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.400 v roce 2023

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/25:00143653

Organizační jednotka

Středoevropský technologický institut

DOI

https://doi.org/10.7554/eLife.98920

UT WoS

001600113200001

Klíčová slova anglicky

dynamics; complexity; consciousness

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 2. 2026 10:13, Mgr. Eva Dubská

Anotace

V originále

Signatures of consciousness are found in spectral and temporal properties of neuronal activity. Among these, spatiotemporal complexity after a perturbation has recently emerged as a robust metric to infer levels of consciousness. Perturbation paradigms remain, however, difficult to perform routinely. To discover alternative paradigms and metrics, we systematically explore brain stimulation and resting-state activity in a whole-brain model. We find that perturbational complexity only occurs when the brain model operates within a specific dynamical regime, in which spontaneous activity produces a large degree of functional network reorganizations referred to as being fluid. The regime of high brain fluidity is characterized by a small battery of metrics drawn from dynamical systems theory and predicts the impact of consciousness-altering drugs (Xenon, Propofol, and Ketamine). We validate the predictions in a cohort of 15 subjects at various stages of consciousness and demonstrate their agreement with previously reported perturbational complexity, but in a more accessible paradigm. Beyond the facilitation in clinical use, the metrics highlight complexity properties of brain dynamics in support of the emergence of consciousness.

Návaznosti

101130827, interní kód MU

Název: Personalizing virtual brains with neurodegenerative disease: noninvasive stimulation approach

Investor: Evropská unie, Personalizing virtual brains with neurodegenerative disease: noninvasive stimulation approach, Marie Skłodowska-Curie Postdoctoral Fellowships (MSCA PF)

Citovat

BREYTON, Martin; Jan FOUSEK; Giovanni RABUFFO; Pierpaolo SORRENTINO; Lionel KUSCH; Marcello MASSIMINI; Spase PETKOSKI a Viktor JIRSA. Spatiotemporal brain complexity quantifies consciousness outside of perturbation paradigms. elife. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD, 2025, roč. 13, oct, s. 1-18. ISSN 2050-084X. Dostupné z: https://doi.org/10.7554/eLife.98920.

@article{2551986,
   author = {Breyton, Martin and Fousek, Jan and Rabuffo, Giovanni and Sorrentino, Pierpaolo and Kusch, Lionel and Massimini, Marcello and Petkoski, Spase and Jirsa, Viktor},
   article_location = {CAMBRIDGE},
   article_number = {oct},
   doi = {https://doi.org/10.7554/eLife.98920},
   keywords = {dynamics; complexity; consciousness},
   language = {eng},
   issn = {2050-084X},
   journal = {elife},
   title = {Spatiotemporal brain complexity quantifies consciousness outside of perturbation paradigms},
   url = {https://elifesciences.org/articles/98920},
   volume = {13},
   year = {2025}
}

TY  - JOUR
ID  - 2551986
AU  - Breyton, Martin - Fousek, Jan - Rabuffo, Giovanni - Sorrentino, Pierpaolo - Kusch, Lionel - Massimini, Marcello - Petkoski, Spase - Jirsa, Viktor
PY  - 2025
TI  - Spatiotemporal brain complexity quantifies consciousness outside of perturbation paradigms
JF  - elife
VL  - 13
IS  - oct
SP  - 1-18
EP  - 1-18
PB  - ELIFE SCIENCES PUBLICATIONS LTD
SN  - 2050084X
KW  - dynamics
KW  - complexity
KW  - consciousness
UR  - https://elifesciences.org/articles/98920
N2  - Signatures of consciousness are found in spectral and temporal properties of neuronal activity. Among these, spatiotemporal complexity after a perturbation has recently emerged as a robust metric to infer levels of consciousness. Perturbation paradigms remain, however, difficult to perform routinely. To discover alternative paradigms and metrics, we systematically explore brain stimulation and resting-state activity in a whole-brain model. We find that perturbational complexity only occurs when the brain model operates within a specific dynamical regime, in which spontaneous activity produces a large degree of functional network reorganizations referred to as being fluid. The regime of high brain fluidity is characterized by a small battery of metrics drawn from dynamical systems theory and predicts the impact of consciousness-altering drugs (Xenon, Propofol, and Ketamine). We validate the predictions in a cohort of 15 subjects at various stages of consciousness and demonstrate their agreement with previously reported perturbational complexity, but in a more accessible paradigm. Beyond the facilitation in clinical use, the metrics highlight complexity properties of brain dynamics in support of the emergence of consciousness.
ER  -

BREYTON, Martin; Jan FOUSEK; Giovanni RABUFFO; Pierpaolo SORRENTINO; Lionel KUSCH; Marcello MASSIMINI; Spase PETKOSKI a Viktor JIRSA. Spatiotemporal brain complexity quantifies consciousness outside of perturbation paradigms. \textit{elife}. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD, 2025, roč.~13, oct, s.~1-18. ISSN~2050-084X. Dostupné z: https://doi.org/10.7554/eLife.98920.

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