Skin and gut microbiota composition and immune regulatory
response differentiate IgE and non-IgE cow’s milk allergy
patients with atopic dermatitis

J 2025

Skin and gut microbiota composition and immune regulatory response differentiate IgE and non-IgE cow’s milk allergy patients with atopic dermatitis

THON, Tomas; Eliska KOPELENTOVA; Dagmar SRUTKOVA; Stepan COUFAL; Jakub KREISINGER et al.

Základní údaje

Originální název

Skin and gut microbiota composition and immune regulatory response differentiate IgE and non-IgE cow’s milk allergy patients with atopic dermatitis

Autoři

Vydání

ISCIENCE, UNITED STATES, CELL PRESS, 2025, 2589-0042

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.100 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/25:00143640

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

cow’s milk allergy; atopic dermatitis; skin microbiota; gut microbiota; immune regulatory response

Štítky

CF GEN

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 3. 2026 10:22, Mgr. Eva Dubská

Anotace

V originále

Precise identification of food allergy and atopic dermatitis (AD) endotypes in infants is needed to target treatments effectively. Therefore, we investigated markers associated with changes in the microbiota and immune responses within the gut-skin axis of immunoglobulin E (IgE) and non-IgE-mediated cow’s milk allergy (CMA) patients with AD. We report that the skin microbiota of patients with IgE CMA differs significantly from healthy controls (HCs) and from patients with non-IgE CMA, despite similar AD severity. Regarding the immune response to bacteria, we found a significant increase in soluble CD14 in patients with non-IgE CMA compared to patients with IgE CMA. Patients with a non-IgE CMA have more regulatory T cells in their blood that migrate into the intestine than patients with IgE CMA. These findings provide insights into the complex interplay between the damaged epithelial barrier, microbiome, and immune responses in CMA patients with AD.

Návaznosti

MUNI/A/1685/2024, interní kód MU

Název: Nové přístupy ve výzkumu, diagnostice a terapii hematologických malignit XII

Investor: Masarykova univerzita, Nové přístupy ve výzkumu, diagnostice a terapii hematologických malignit XII

90267, velká výzkumná infrastruktura

Název: NCMG III

Citovat

THON, Tomas; Eliska KOPELENTOVA; Dagmar SRUTKOVA; Stepan COUFAL; Jakub KREISINGER; Filip ROB; Zuzana REISS; Miloslav KVERKA; Stepanka CAPKOVA; Jana CADOVA; Lucie BULANTOVÁ; Vojtěch BYSTRÝ; Anna SEDIVA; Helena TLASKALOVA-HOGENOVA; Zuzana JIRASKOVA ZAKOSTELSKA a Andrea POLOUCKOVA. Skin and gut microbiota composition and immune regulatory response differentiate IgE and non-IgE cow’s milk allergy patients with atopic dermatitis. ISCIENCE. UNITED STATES: CELL PRESS, 2025, roč. 28, č. 12, s. 1-22. ISSN 2589-0042. Dostupné z: https://doi.org/10.1016/j.isci.2025.113943.

@article{2552021,
   author = {Thon, Tomas and Kopelentova, Eliska and Srutkova, Dagmar and Coufal, Stepan and Kreisinger, Jakub and Rob, Filip and Reiss, Zuzana and Kverka, Miloslav and Capkova, Stepanka and Cadova, Jana and Bulantová, Lucie and Bystrý, Vojtěch and Sediva, Anna and TlaskalovaandHogenova, Helena and Jiraskova Zakostelska, Zuzana and Polouckova, Andrea},
   article_location = {UNITED STATES},
   article_number = {12},
   doi = {https://doi.org/10.1016/j.isci.2025.113943},
   keywords = {cow’s milk allergy; atopic dermatitis; skin microbiota; gut microbiota; immune regulatory response},
   language = {eng},
   issn = {2589-0042},
   journal = {ISCIENCE},
   title = {Skin and gut microbiota composition and immune regulatory response differentiate IgE and non-IgE cow’s milk allergy patients with atopic dermatitis},
   url = {https://www.sciencedirect.com/science/article/pii/S2589004225022047?via%3Dihub},
   volume = {28},
   year = {2025}
}

TY  - JOUR
ID  - 2552021
AU  - Thon, Tomas - Kopelentova, Eliska - Srutkova, Dagmar - Coufal, Stepan - Kreisinger, Jakub - Rob, Filip - Reiss, Zuzana - Kverka, Miloslav - Capkova, Stepanka - Cadova, Jana - Bulantová, Lucie - Bystrý, Vojtěch - Sediva, Anna - Tlaskalova-Hogenova, Helena - Jiraskova Zakostelska, Zuzana - Polouckova, Andrea
PY  - 2025
TI  - Skin and gut microbiota composition and immune regulatory response differentiate IgE and non-IgE cow’s milk allergy patients with atopic dermatitis
JF  - ISCIENCE
VL  - 28
IS  - 12
SP  - 1-22
EP  - 1-22
PB  - CELL PRESS
SN  - 25890042
KW  - cow’s milk allergy
KW  - atopic dermatitis
KW  - skin microbiota
KW  - gut microbiota
KW  - immune regulatory response
UR  - https://www.sciencedirect.com/science/article/pii/S2589004225022047?via%3Dihub
N2  - Precise identification of food allergy and atopic dermatitis (AD) endotypes in infants is needed to target treatments effectively. Therefore, we investigated markers associated with changes in the microbiota and immune responses within the gut-skin axis of immunoglobulin E (IgE) and non-IgE-mediated cow’s milk allergy (CMA) patients with AD. We report that the skin microbiota of patients with IgE CMA differs significantly from healthy controls (HCs) and from patients with non-IgE CMA, despite similar AD severity. Regarding the immune response to bacteria, we found a significant increase in soluble CD14 in patients with non-IgE CMA compared to patients with IgE CMA. Patients with a non-IgE CMA have more regulatory T cells in their blood that migrate into the intestine than patients with IgE CMA. These findings provide insights into the complex interplay between the damaged epithelial barrier, microbiome, and immune responses in CMA patients with AD.
ER  -

THON, Tomas; Eliska KOPELENTOVA; Dagmar SRUTKOVA; Stepan COUFAL; Jakub KREISINGER; Filip ROB; Zuzana REISS; Miloslav KVERKA; Stepanka CAPKOVA; Jana CADOVA; Lucie BULANTOVÁ; Vojtěch BYSTRÝ; Anna SEDIVA; Helena TLASKALOVA-HOGENOVA; Zuzana JIRASKOVA ZAKOSTELSKA a Andrea POLOUCKOVA. Skin and gut microbiota composition and immune regulatory response differentiate IgE and non-IgE cow’s milk allergy patients with atopic dermatitis. \textit{ISCIENCE}. UNITED STATES: CELL PRESS, 2025, roč.~28, č.~12, s.~1-22. ISSN~2589-0042. Dostupné z: https://doi.org/10.1016/j.isci.2025.113943.

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