The Stability of Drugs Commonly Used in Intensive Care Units
Co-Administered via Feeding Tube and Its Dependence on pH: An
in vitro Study

J 2025

The Stability of Drugs Commonly Used in Intensive Care Units Co-Administered via Feeding Tube and Its Dependence on pH: An in vitro Study

PAPIEŽ, Adriána; Pavel SUK; Radka BARÁNKOVÁ; Pavlína HANČLOVÁ; Vladimír ŠRÁMEK et al.

Základní údaje

Originální název

The Stability of Drugs Commonly Used in Intensive Care Units Co-Administered via Feeding Tube and Its Dependence on pH: An in vitro Study

Autoři

PAPIEŽ, Adriána; Pavel SUK ; Radka BARÁNKOVÁ; Pavlína HANČLOVÁ; Vladimír ŠRÁMEK a Klára ODEHNALOVÁ

Vydání

PHARMACOLOGY, Basel, KARGER, 2025, 0031-7012

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30221 Critical care medicine and Emergency medicine

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.200 v roce 2024

Označené pro přenos do RIV

Organizační jednotka

Farmaceutická fakulta

Klíčová slova česky

Feeding tube, Drug administration, Drug compatibility, Intensive care

Klíčová slova anglicky

Feeding tube; Drug administration; Drug compatibility; Intensive care

Štítky

14110122, podil, ÚChL

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 4. 2026 10:31, Mgr. Irena Doubková

Anotace

V originále

Introduction: The administration of medication through feeding tubes (FTs) represents a critical aspect of routine nursing practice. Although guidelines recommend the separate administration of medications to minimize potential interactions, it is common practice in the clinical settings for medications to be combined and administered simultaneously. Since there is a lack of data on this topic, this study assesses the stability of drugs crushed and mixed in water solution concurrently for administration through FT. Methods: The drug compatibility was evaluated in vitro by monitoring the changes in drug content in water solution over time and identifying potential degradation products using a high-performance liquid chromatography system. Results: The majority of drugs (acetylsalicylic acid, clopidogrel, atorvastatin, furosemide, and prasugrel) maintained their stability during the entire preparation process. The only medication that showed degradation over time was pantoprazole (especially when combined with acetylsalicylic acid and clopidogrel), which was attributed to the acidic environment. The remaining drugs (acetylsalicylic acid, clopidogrel, atorvastatin, furosemide, and prasugrel) maintained their stability during the entire preparation process. Conclusion: This study proves that most drugs can be prepared and administered simultaneously, with the exception of acid-labile drugs, which undergo significant degradation in acidic solutions.

Citovat

PAPIEŽ, Adriána; Pavel SUK; Radka BARÁNKOVÁ; Pavlína HANČLOVÁ; Vladimír ŠRÁMEK a Klára ODEHNALOVÁ. The Stability of Drugs Commonly Used in Intensive Care Units Co-Administered via Feeding Tube and Its Dependence on pH: An in vitro Study. PHARMACOLOGY. Basel: KARGER, 2025, roč. 2026, s. 1-8. ISSN 0031-7012. Dostupné z: https://doi.org/10.1159/000550187.

@article{2552800,
   author = {Papiež, Adriána and Suk, Pavel and Baránková, Radka and Hančlová, Pavlína and Šrámek, Vladimír and Odehnalová, Klára},
   article_location = {Basel},
   doi = {https://doi.org/10.1159/000550187},
   keywords = {Feeding tube; Drug administration; Drug compatibility; Intensive care},
   language = {eng},
   issn = {0031-7012},
   journal = {PHARMACOLOGY},
   title = {The Stability of Drugs Commonly Used in Intensive Care Units Co-Administered via Feeding Tube and Its Dependence on pH: An in vitro Study},
   url = {https://karger.com/pha/article/doi/10.1159/000550187/941927/The-Stability-of-Drugs-Commonly-Used-in-Intensive},
   volume = {2026},
   year = {2025}
}

TY  - JOUR
ID  - 2552800
AU  - Papiež, Adriána - Suk, Pavel - Baránková, Radka - Hančlová, Pavlína - Šrámek, Vladimír - Odehnalová, Klára
PY  - 2025
TI  - The Stability of Drugs Commonly Used in Intensive Care Units Co-Administered via Feeding Tube and Its Dependence on pH: An in vitro Study
JF  - PHARMACOLOGY
VL  - 2026
SP  - 1-8
EP  - 1-8
PB  - KARGER
SN  - 00317012
KW  - Feeding tube
KW  - Drug administration
KW  - Drug compatibility
KW  - Intensive care
UR  - https://karger.com/pha/article/doi/10.1159/000550187/941927/The-Stability-of-Drugs-Commonly-Used-in-Intensive
N2  - Introduction: The administration of medication through feeding tubes (FTs) represents a critical aspect of routine nursing practice. Although guidelines recommend the separate administration of medications to minimize potential interactions, it is common practice in the clinical settings for medications to be combined and administered simultaneously. Since there is a lack of data on this topic, this study assesses the stability of drugs crushed and mixed in water solution concurrently for administration through FT. Methods: The drug compatibility was evaluated in vitro by monitoring the changes in drug content in water solution over time and identifying potential degradation products using a high-performance liquid chromatography system. Results: The majority of drugs (acetylsalicylic acid, clopidogrel, atorvastatin, furosemide, and prasugrel) maintained their stability during the entire preparation process. The only medication that showed degradation over time was pantoprazole (especially when combined with acetylsalicylic acid and clopidogrel), which was attributed to the acidic environment. The remaining drugs (acetylsalicylic acid, clopidogrel, atorvastatin, furosemide, and prasugrel) maintained their stability during the entire preparation process. Conclusion: This study proves that most drugs can be prepared and administered simultaneously, with the exception of acid-labile drugs, which undergo significant degradation in acidic solutions.
ER  -

PAPIEŽ, Adriána; Pavel SUK; Radka BARÁNKOVÁ; Pavlína HANČLOVÁ; Vladimír ŠRÁMEK a Klára ODEHNALOVÁ. The Stability of Drugs Commonly Used in Intensive Care Units Co-Administered via Feeding Tube and Its Dependence on pH: An in vitro Study. \textit{PHARMACOLOGY}. Basel: KARGER, 2025, roč.~2026, s.~1-8. ISSN~0031-7012. Dostupné z: https://doi.org/10.1159/000550187.

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