Enamel decussation pattern originates from directional sliding
of ameloblasts

J 2026

Enamel decussation pattern originates from directional sliding of ameloblasts

RAKULTSEV, Vladislav; Josef LAVICKÝ; Marcos GONZÁLEZ LÓPEZ; Klára CIGOŠOVÁ; Igor ADAMEYKO et al.

Základní údaje

Originální název

Enamel decussation pattern originates from directional sliding of ameloblasts

Autoři

RAKULTSEV, Vladislav; Josef LAVICKÝ; Marcos GONZÁLEZ LÓPEZ; Klára CIGOŠOVÁ ; Igor ADAMEYKO a Jan KŘIVÁNEK

Vydání

International Journal of Oral Science, SICHUAN UNIV, 2026, 1674-2818

Další údaje

Typ výsledku

Článek v odborném periodiku

Obor

10605 Developmental biology

Stát vydavatele

Čína

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 12.200 v roce 2024

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1038/s41368-025-00412-5

Změněno: 9. 2. 2026 09:56, Mgr. Tereza Slaměníková

Anotace

V originále

Enamel, the inorganic tissue covering the crowns of teeth, is known for its remarkable resilience and hardness. These properties originate from its high proportion of mineralized matrix and complex internal microarchitecture. On an ultrastructural level, it consists of directionally arranged enamel prisms. Continuously growing rodent incisors are an exemplary case of this phenomenon. Their enamel has a consistent decussation pattern, providing teeth with extremely high resistance and ensuring they remain constantly sharp. While the decussation pattern has been described in detail, mechanisms behind its formation have not been experimentally proven. Here, we show that the highly organized enamel micropattern is generated by directional epithelial sliding of enamel-forming ameloblasts in vivo. Our results detail how enamel micropatterning stems from individual cell cluster segregation and subsequent reciprocal interweaving. Based on this determination, we introduce and experimentally demonstrate a new model of enamel decussation pattern formation.

Citovat

RAKULTSEV, Vladislav; Josef LAVICKÝ; Marcos GONZÁLEZ LÓPEZ; Klára CIGOŠOVÁ; Igor ADAMEYKO a Jan KŘIVÁNEK. Enamel decussation pattern originates from directional sliding of ameloblasts. International Journal of Oral Science. SICHUAN UNIV, 2026. ISSN 1674-2818. Dostupné z: https://doi.org/10.1038/s41368-025-00412-5.

@article{2553637,
   author = {Rakultsev, Vladislav and Lavický, Josef and González López, Marcos and Cigošová, Klára and Adameyko, Igor and Křivánek, Jan},
   doi = {https://doi.org/10.1038/s41368-025-00412-5},
   issn = {1674-2818},
   journal = {International Journal of Oral Science},
   title = {Enamel decussation pattern originates from directional sliding of ameloblasts},
   url = {https://www.nature.com/articles/s41368-025-00412-5#Abs1},
   year = {2026}
}

TY  - JOUR
ID  - 2553637
AU  - Rakultsev, Vladislav - Lavický, Josef - González López, Marcos - Cigošová, Klára - Adameyko, Igor - Křivánek, Jan
PY  - 2026
TI  - Enamel decussation pattern originates from directional sliding of ameloblasts
JF  - International Journal of Oral Science
PB  - SICHUAN UNIV
SN  - 16742818
UR  - https://www.nature.com/articles/s41368-025-00412-5#Abs1
N2  - Enamel, the inorganic tissue covering the crowns of teeth, is known for its remarkable resilience and hardness. These properties originate from its high proportion of mineralized matrix and complex internal microarchitecture. On an ultrastructural level, it consists of directionally arranged enamel prisms. Continuously growing rodent incisors are an exemplary case of this phenomenon. Their enamel has a consistent decussation pattern, providing teeth with extremely high resistance and ensuring they remain constantly sharp. While the decussation pattern has been described in detail, mechanisms behind its formation have not been experimentally proven. Here, we show that the highly organized enamel micropattern is generated by directional epithelial sliding of enamel-forming ameloblasts in vivo. Our results detail how enamel micropatterning stems from individual cell cluster segregation and subsequent reciprocal interweaving. Based on this determination, we introduce and experimentally demonstrate a new model of enamel decussation pattern formation.
ER  -

RAKULTSEV, Vladislav; Josef LAVICKÝ; Marcos GONZÁLEZ LÓPEZ; Klára CIGOŠOVÁ; Igor ADAMEYKO a Jan KŘIVÁNEK. Enamel decussation pattern originates from directional sliding of ameloblasts. \textit{International Journal of Oral Science}. SICHUAN UNIV, 2026. ISSN~1674-2818. Dostupné z: https://doi.org/10.1038/s41368-025-00412-5.

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