Drug Dissolution Enhancement Using 3D-Printed Silica-Based Oral
Films

J 2025

Drug Dissolution Enhancement Using 3D-Printed Silica-Based Oral Films

BLAHÁČKOVÁ, Dagmar; Jan ELBL; Lukas C LAMMERDING; Eliska MASKOVA; Jan MUSELÍK et al.

Základní údaje

Originální název

Drug Dissolution Enhancement Using 3D-Printed Silica-Based Oral Films

Autoři

BLAHÁČKOVÁ, Dagmar; Jan ELBL ; Lukas C LAMMERDING; Eliska MASKOVA; Jan MUSELÍK ; Josef KASLIK a Jan GAJDZIOK

Vydání

AAPS JOURNAL, NEW YORK, SPRINGER, 2025, 1550-7416

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.700 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14160/25:00143719

Organizační jednotka

Farmaceutická fakulta

Klíčová slova anglicky

Drug crystallization; Individualized therapy; Orodispersible film; Porous film; Silica

Štítky

rivok, ÚFT

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 3. 2026 19:37, Mgr. Irena Doubková

Anotace

V originále

Orodispersible films (ODFs) are increasingly employed for individualized drug delivery due to their ease of administration and precise dosing. However, their drug loading capacity is often limited by the need to maintain thin, flexible structures, posing a particular challenge for incorporating poorly soluble drugs. This study aimed to develop and characterize porous ODF matrices optimized for 3D printing of medicated inks. The primary objective was to investigate the impact of macroporosity on the dissolution kinetics of both poorly soluble and readily soluble drugs, with a focus on enhancing the release of the poorly soluble dexamethasone. Porous ODFs were fabricated via solvent casting using silica- and silicate-based porogens, then loaded with caffeine or dexamethasone through 3D printing. The films were comprehensively characterized using structural (micro-CT, BET), mechanical, and solid-state techniques (SEM, Raman microscopy, FTIR, XRD) to assess porosity, drug crystallization behavior, and drug-matrix compatibility. Drug release was evaluated through dissolution studies. Silica-based porogens yielded films with tunable macroporosity, supporting high drug loads (up to 3-5 times the ink volume). Dexamethasone printed on the SY2 substrate exhibited markedly enhanced dissolution (79.2 +/- 1.8%) compared to its powdered form (29.9 +/- 11.5%), achieving 61.5% release within 20 min. In contrast, caffeine (readily soluble) showed a transient reduction in dissolution rate during the initial two minutes, attributed to increased particle size and delayed film disintegration. Overall, integrating porous matrix design with 3D printing significantly improved the dissolution of poorly soluble dexamethasone without inducing drug-matrix interactions, confirming that structural modifications drive the enhanced release.

Citovat

BLAHÁČKOVÁ, Dagmar; Jan ELBL; Lukas C LAMMERDING; Eliska MASKOVA; Jan MUSELÍK; Josef KASLIK a Jan GAJDZIOK. Drug Dissolution Enhancement Using 3D-Printed Silica-Based Oral Films. AAPS JOURNAL. NEW YORK: SPRINGER, 2025, roč. 28, č. 1, s. 1-22. ISSN 1550-7416. Dostupné z: https://doi.org/10.1208/s12248-025-01185-9.

@article{2555398,
   author = {Blaháčková, Dagmar and Elbl, Jan and Lammerding, Lukas C and Maskova, Eliska and Muselík, Jan and Kaslik, Josef and Gajdziok, Jan},
   article_location = {NEW YORK},
   article_number = {1},
   doi = {https://doi.org/10.1208/s12248-025-01185-9},
   keywords = {Drug crystallization; Individualized therapy; Orodispersible film; Porous film; Silica},
   language = {eng},
   issn = {1550-7416},
   journal = {AAPS JOURNAL},
   title = {Drug Dissolution Enhancement Using 3D-Printed Silica-Based Oral Films},
   url = {https://link.springer.com/article/10.1208/s12248-025-01185-9},
   volume = {28},
   year = {2025}
}

TY  - JOUR
ID  - 2555398
AU  - Blaháčková, Dagmar - Elbl, Jan - Lammerding, Lukas C - Maskova, Eliska - Muselík, Jan - Kaslik, Josef - Gajdziok, Jan
PY  - 2025
TI  - Drug Dissolution Enhancement Using 3D-Printed Silica-Based Oral Films
JF  - AAPS JOURNAL
VL  - 28
IS  - 1
SP  - 1-22
EP  - 1-22
PB  - SPRINGER
SN  - 15507416
KW  - Drug crystallization
KW  - Individualized therapy
KW  - Orodispersible film
KW  - Porous film
KW  - Silica
UR  - https://link.springer.com/article/10.1208/s12248-025-01185-9
N2  - Orodispersible films (ODFs) are increasingly employed for individualized drug delivery due to their ease of administration and precise dosing. However, their drug loading capacity is often limited by the need to maintain thin, flexible structures, posing a particular challenge for incorporating poorly soluble drugs. This study aimed to develop and characterize porous ODF matrices optimized for 3D printing of medicated inks. The primary objective was to investigate the impact of macroporosity on the dissolution kinetics of both poorly soluble and readily soluble drugs, with a focus on enhancing the release of the poorly soluble dexamethasone. Porous ODFs were fabricated via solvent casting using silica- and silicate-based porogens, then loaded with caffeine or dexamethasone through 3D printing. The films were comprehensively characterized using structural (micro-CT, BET), mechanical, and solid-state techniques (SEM, Raman microscopy, FTIR, XRD) to assess porosity, drug crystallization behavior, and drug-matrix compatibility. Drug release was evaluated through dissolution studies. Silica-based porogens yielded films with tunable macroporosity, supporting high drug loads (up to 3-5 times the ink volume). Dexamethasone printed on the SY2 substrate exhibited markedly enhanced dissolution (79.2 +/- 1.8%) compared to its powdered form (29.9 +/- 11.5%), achieving 61.5% release within 20 min. In contrast, caffeine (readily soluble) showed a transient reduction in dissolution rate during the initial two minutes, attributed to increased particle size and delayed film disintegration. Overall, integrating porous matrix design with 3D printing significantly improved the dissolution of poorly soluble dexamethasone without inducing drug-matrix interactions, confirming that structural modifications drive the enhanced release.
ER  -

BLAHÁČKOVÁ, Dagmar; Jan ELBL; Lukas C LAMMERDING; Eliska MASKOVA; Jan MUSELÍK; Josef KASLIK a Jan GAJDZIOK. Drug Dissolution Enhancement Using 3D-Printed Silica-Based Oral Films. \textit{AAPS JOURNAL}. NEW YORK: SPRINGER, 2025, roč.~28, č.~1, s.~1-22. ISSN~1550-7416. Dostupné z: https://doi.org/10.1208/s12248-025-01185-9.

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