Diabetic cardiomyopathy modelling using human pluripotent stem
cell derived cardiac organoids

a 2026

Diabetic cardiomyopathy modelling using human pluripotent stem cell derived cardiac organoids

POLÁCHOVÁ, Anežka; Deborah BECKEROVÁ; Martin PEŠL a Vladimír ROTREKL

Základní údaje

Originální název

Diabetic cardiomyopathy modelling using human pluripotent stem cell derived cardiac organoids

Autoři

POLÁCHOVÁ, Anežka; Deborah BECKEROVÁ; Martin PEŠL a Vladimír ROTREKL

Vydání

EMBL Conference: The new cardiobiology: engineering, vascular, and molecular insights, 2026

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Odkazy

URL

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Diabetes; diabetic cardiomyopathy; cardiovascular progenitors

Změněno: 23. 2. 2026 13:50, Mgr. Bc. Deborah Beckerová

Anotace

V originále

Diabetic cardiomyopathy is a disease characterized by structural alterations of the cardiac muscle, fibrosis, and reduced systolic function, which can ultimately lead to heart failure. Chronic hyperglycaemia is associated with elevated oxidative stress, and we hypothesize that it could induce DNA damage and/or changes in signalling pathways effecting metabolism and thus alter the fate of stem or progenitor cells. This could represent a potential mechanism contributing to the pathogenesis of diabetic cardiomyopathy. To investigate the molecular mechanisms underlying this disease, we employ a model based on human pluripotent stem cells and derived cardiac organoids exposed to aberrant glucose concentrations. Using this model, we analyse the impact of hyperglycaemic conditions on cardiac tissue development and the onset of pathological changes. For instance, aberrant glucose levels result into impaired progression through already early stages of organoid differentiation, particularly mesoderm specification and onset of maturation. These insights may contribute to a deeper understanding of the cellular and molecular mechanisms linking diabetes to cardiomyopathy and provide novel targets for prevention or therapy. Project was funded by project National Institute for Research of Metabolic and Cardiovascular Diseases (Programme EXCELES, ID Project No. LX22NPO5104) – Funded by the European Union – Next Generation EU.

Návaznosti

LX22NPO5104, projekt VaV

Název: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění (Akronym: CarDia)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní institut pro léčbu metabolických a kardiovaskulárních onemocnění, 5.1 EXCELES

Citovat

POLÁCHOVÁ, Anežka; Deborah BECKEROVÁ; Martin PEŠL a Vladimír ROTREKL. Diabetic cardiomyopathy modelling using human pluripotent stem cell derived cardiac organoids. In EMBL Conference: The new cardiobiology: engineering, vascular, and molecular insights. 2026.

@proceedings{2556241,
   author = {Poláchová, Anežka and Beckerová, Deborah and Pešl, Martin and Rotrekl, Vladimír},
   booktitle = {EMBL Conference: The new cardiobiology: engineering, vascular, and molecular insights},
   keywords = {Diabetes; diabetic cardiomyopathy; cardiovascular progenitors},
   language = {eng},
   title = {Diabetic cardiomyopathy modelling using human pluripotent stem cell derived cardiac organoids},
   url = {https://is.muni.cz/auth/publication/2556157/5MEa2ZXJTSfAafY8bFQi_2_full.pdf},
   year = {2026}
}

TY  - CONF
ID  - 2556241
AU  - Poláchová, Anežka - Beckerová, Deborah - Pešl, Martin - Rotrekl, Vladimír
PY  - 2026
TI  - Diabetic cardiomyopathy modelling using human pluripotent stem cell derived cardiac organoids
KW  - Diabetes
KW  - diabetic cardiomyopathy
KW  - cardiovascular progenitors
UR  - https://is.muni.cz/auth/publication/2556157/5MEa2ZXJTSfAafY8bFQi_2_full.pdf
N2  - Diabetic cardiomyopathy is a disease characterized by structural alterations of the cardiac muscle, fibrosis, and reduced systolic function, which can ultimately lead to heart failure. Chronic hyperglycaemia is associated with elevated oxidative stress, and we hypothesize that it could induce DNA damage and/or changes in signalling pathways effecting metabolism and thus alter the fate of stem or progenitor cells. This could represent a potential mechanism contributing to the pathogenesis of diabetic cardiomyopathy. To investigate the molecular mechanisms underlying this disease, we employ a model based on human pluripotent stem cells and derived cardiac organoids exposed to aberrant glucose concentrations. Using this model, we analyse the impact of hyperglycaemic conditions on cardiac tissue development and the onset of pathological changes. For instance, aberrant glucose levels result into impaired progression through already early stages of organoid differentiation, particularly mesoderm specification and onset of maturation. These insights may contribute to a deeper understanding of the cellular and molecular mechanisms linking diabetes to cardiomyopathy and provide novel targets for prevention or therapy. Project was funded by project National Institute for Research of Metabolic and Cardiovascular Diseases (Programme EXCELES, ID Project No. LX22NPO5104) – Funded by the European Union – Next Generation EU.
ER  -

POLÁCHOVÁ, Anežka; Deborah BECKEROVÁ; Martin PEŠL a Vladimír ROTREKL. Diabetic cardiomyopathy modelling using human pluripotent stem cell derived cardiac organoids. In \textit{EMBL Conference: The new cardiobiology: engineering, vascular, and molecular insights}. 2026.

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