Low Fibrinogen Levels Are Associated with an Increased Risk of
Parenchymal Hematoma in Ischemic Stroke Treated with
Intravenous Thrombolysis

J 2026

Low Fibrinogen Levels Are Associated with an Increased Risk of Parenchymal Hematoma in Ischemic Stroke Treated with Intravenous Thrombolysis

ŠIMŮNEK, Libor; Veronika KUNEŠOVÁ; Lucie BUREŠOVÁ; Viktor WEISS; René JURA et al.

Základní údaje

Originální název

Low Fibrinogen Levels Are Associated with an Increased Risk of Parenchymal Hematoma in Ischemic Stroke Treated with Intravenous Thrombolysis

Autoři

ŠIMŮNEK, Libor; Veronika KUNEŠOVÁ; Lucie BUREŠOVÁ; Viktor WEISS; René JURA; Petr GEIER; Petra REKOVÁ; Daniel VÁCLAVÍK; Martin ŠRÁMEK; Robert MIKULÍK a Roman HERZIG

Vydání

Journal of Clinical Medicine, BASEL, MDPI, 2026, 2077-0383

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30218 General and internal medicine

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.900 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova česky

ischemic stroke; intravenous thrombolysis; alteplase; fibrinogen; intracerebral hemorrhage; parenchymal hematoma

Klíčová slova anglicky

ischemic stroke; intravenous thrombolysis; alteplase; fibrinogen; intracerebral hemorrhage; parenchymal hematoma

Štítky

14110127, 14110221, 14110525, 14119710, CZECRIN, Excelence Science, FNUSA, RIV, rivok, user, článek v časopise

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 4. 2026 12:20, Mgr. Tereza Miškechová

Anotace

V originále

Background: Intravenous thrombolysis (IVT), used in acute ischemic stroke (AIS), may be complicated by the development of intracranial hemorrhage. The role of fibrinogen levels, including their decrease, as a possible predictor of intracranial hemorrhage, has not yet been fully clarified. We aimed to evaluate the association between fibrinogen levels and their decrease 6 and 24 h after IVT and the risk of parenchymal hematoma (PH), as the clinically most significant type of intracranial hemorrhage. Methods: In an observational, nationwide, multicenter study, data from adult patients who underwent IVT for AIS from the Registry of Stroke Care Quality (RES-Q) in the Czech Republic (2019–2021) were analyzed. An association between fibrinogen levels and their decrease 6 and 24 h after IVT and the risk of PH was assessed. Results: We analyzed a set of 27 patients with PH (13 males; median age 78.0 years) and a control group (CG) of 97 patients without intracranial hemorrhage (58 males; median age 78.0 years). Fibrinogen levels 6 h after IVT (median 1.93 [PH] vs. 2.57 [CG] g/L, p = 0.012) and the ratio of baseline fibrinogen to fibrinogen 6 h after IVT (median 1.78 [PH] vs. 1.26 [CG]; p = 0.008) were associated with the development of PH. The optimal cut-off value of fibrinogen 6 h after IVT for predicting PH was <2.0 g/L.

Návaznosti

90249, velká výzkumná infrastruktura

Název: CZECRIN IV

Citovat

ŠIMŮNEK, Libor; Veronika KUNEŠOVÁ; Lucie BUREŠOVÁ; Viktor WEISS; René JURA; Petr GEIER; Petra REKOVÁ; Daniel VÁCLAVÍK; Martin ŠRÁMEK; Robert MIKULÍK a Roman HERZIG. Low Fibrinogen Levels Are Associated with an Increased Risk of Parenchymal Hematoma in Ischemic Stroke Treated with Intravenous Thrombolysis. Journal of Clinical Medicine. BASEL: MDPI, 2026, roč. 15, č. 5, s. 1-15. ISSN 2077-0383. Dostupné z: https://doi.org/10.3390/jcm15051691.

@article{2556619,
   author = {Šimůnek, Libor and Kunešová, Veronika and Burešová, Lucie and Weiss, Viktor and Jura, René and Geier, Petr and Reková, Petra and Václavík, Daniel and Šrámek, Martin and Mikulík, Robert and Herzig, Roman},
   article_location = {BASEL},
   article_number = {5},
   doi = {https://doi.org/10.3390/jcm15051691},
   keywords = {ischemic stroke; intravenous thrombolysis; alteplase; fibrinogen; intracerebral hemorrhage; parenchymal hematoma},
   language = {eng},
   issn = {2077-0383},
   journal = {Journal of Clinical Medicine},
   title = {Low Fibrinogen Levels Are Associated with an Increased Risk of Parenchymal Hematoma in Ischemic Stroke Treated with Intravenous Thrombolysis},
   url = {https://www.mdpi.com/2077-0383/15/5/1691},
   volume = {15},
   year = {2026}
}

TY  - JOUR
ID  - 2556619
AU  - Šimůnek, Libor - Kunešová, Veronika - Burešová, Lucie - Weiss, Viktor - Jura, René - Geier, Petr - Reková, Petra - Václavík, Daniel - Šrámek, Martin - Mikulík, Robert - Herzig, Roman
PY  - 2026
TI  - Low Fibrinogen Levels Are Associated with an Increased Risk of Parenchymal Hematoma in Ischemic Stroke Treated with Intravenous Thrombolysis
JF  - Journal of Clinical Medicine
VL  - 15
IS  - 5
SP  - 1-15
EP  - 1-15
PB  - MDPI
SN  - 20770383
KW  - ischemic stroke
KW  - intravenous thrombolysis
KW  - alteplase
KW  - fibrinogen
KW  - intracerebral hemorrhage
KW  - parenchymal hematoma
UR  - https://www.mdpi.com/2077-0383/15/5/1691
N2  - Background: Intravenous thrombolysis (IVT), used in acute ischemic stroke (AIS), may be complicated by the development of intracranial hemorrhage. The role of fibrinogen levels, including their decrease, as a possible predictor of intracranial hemorrhage, has not yet been fully clarified. We aimed to evaluate the association between fibrinogen levels and their decrease 6 and 24 h after IVT and the risk of parenchymal hematoma (PH), as the clinically most significant type of intracranial hemorrhage. Methods: In an observational, nationwide, multicenter study, data from adult patients who underwent IVT for AIS from the Registry of Stroke Care Quality (RES-Q) in the Czech Republic (2019–2021) were analyzed. An association between fibrinogen levels and their decrease 6 and 24 h after IVT and the risk of PH was assessed. Results: We analyzed a set of 27 patients with PH (13 males; median age 78.0 years) and a control group (CG) of 97 patients without intracranial hemorrhage (58 males; median age 78.0 years). Fibrinogen levels 6 h after IVT (median 1.93 [PH] vs. 2.57 [CG] g/L, p = 0.012) and the ratio of baseline fibrinogen to fibrinogen 6 h after IVT (median 1.78 [PH] vs. 1.26 [CG]; p = 0.008) were associated with the development of PH. The optimal cut-off value of fibrinogen 6 h after IVT for predicting PH was <2.0 g/L.
ER  -

ŠIMŮNEK, Libor; Veronika KUNEŠOVÁ; Lucie BUREŠOVÁ; Viktor WEISS; René JURA; Petr GEIER; Petra REKOVÁ; Daniel VÁCLAVÍK; Martin ŠRÁMEK; Robert MIKULÍK a Roman HERZIG. Low Fibrinogen Levels Are Associated with an Increased Risk of Parenchymal Hematoma in Ischemic Stroke Treated with Intravenous Thrombolysis. \textit{Journal of Clinical Medicine}. BASEL: MDPI, 2026, roč.~15, č.~5, s.~1-15. ISSN~2077-0383. Dostupné z: https://doi.org/10.3390/jcm15051691.

Přehled o publikaci