Predictors for sentinel lymph node mapping failure using
indocyanine green injection in apparent early stages of
endometrial cancer: A single-center prospective study

J 2025

Predictors for sentinel lymph node mapping failure using indocyanine green injection in apparent early stages of endometrial cancer: A single-center prospective study

BRETOVÁ, Petra; Luboš MINÁŘ; Petra OVESNÁ; Vít WEINBERGER; Michal FELSINGER et al.

Základní údaje

Originální název

Predictors for sentinel lymph node mapping failure using indocyanine green injection in apparent early stages of endometrial cancer: A single-center prospective study

Autoři

BRETOVÁ, Petra; Luboš MINÁŘ; Petra OVESNÁ ; Vít WEINBERGER; Michal FELSINGER; Michaela KOBLÍŽKOVÁ; Jitka HAUSNEROVÁ; Eva JANDÁKOVÁ a Tatiana STUPKOVÁ

Vydání

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, Hoboken, Wiley, 2025, 0020-7292

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.400 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00143774

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

biopsy; endometrial cancer; myomas; obesity; sentinel lymph node

Štítky

14110230, 14110240, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 25. 2. 2026 14:41, Mgr. Tereza Miškechová

Anotace

V originále

Objective The current study aimed to analyze predictive factors of sentinel lymph node mapping failure in apparently early stages of endometrial cancer using intracervical indocyanine green injection.Methods A single-center prospective study was conducted between June 2019 and August 2023 at the Department of Gynecology and Obstetrics, University Hospital Brno, Czech Republic. All patients with apparently early stage (I or II according to FIGO [International Federation of Gynecology & Obstetrics] 2009) endometrial cancer, who were indicated for sentinel node biopsy were consecutively included. The injection of 4-6 mL of indocyanine green was applied superficially and deeply into cervical tissue at the 3- and 9-o'clock positions. Patients' clinical data, surgical characteristics, and histopathological information were recorded. Univariable and multivariable regression analyses were applied.Results A total of 225 patients were eligible during the study period. Considering bilateral and unilateral failed mapping together, the only statistically significant factors for risk of failure in univariable analysis were body mass index (BMI; P = 0.036), FIGO 2009 stage (P = 0.019), and the presence of a myoma (P = 0.017). Nevertheless, when the multivariable logistic regression analysis was applied, all factors became statistically insignificant except for myoma (P = 0.031). Regarding only bilateral mapping failure, in univariable analysis, BMI (P = 0.021) and FIGO 2009 stage (P = 0.046) were significant predictors of failure. Interestingly, multivariable logistic regression analysis revealed that in addition to BMI (P = 0.007), age (P = 0.004) was also an independent predictor of bilateral failure.Conclusions Higher BMI and age were statistically significant independent factors for bilateral sentinel node mapping failure in early-stage endometrial cancer.

Citovat

BRETOVÁ, Petra; Luboš MINÁŘ; Petra OVESNÁ; Vít WEINBERGER; Michal FELSINGER; Michaela KOBLÍŽKOVÁ; Jitka HAUSNEROVÁ; Eva JANDÁKOVÁ a Tatiana STUPKOVÁ. Predictors for sentinel lymph node mapping failure using indocyanine green injection in apparent early stages of endometrial cancer: A single-center prospective study. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS. Hoboken: Wiley, 2025, roč. 170, č. 3, s. 1214-1224. ISSN 0020-7292. Dostupné z: https://doi.org/10.1002/ijgo.70123.

@article{2556701,
   author = {Bretová, Petra and Minář, Luboš and Ovesná, Petra and Weinberger, Vít and Felsinger, Michal and Koblížková, Michaela and Hausnerová, Jitka and Jandáková, Eva and Stupková, Tatiana},
   article_location = {Hoboken},
   article_number = {3},
   doi = {https://doi.org/10.1002/ijgo.70123},
   keywords = {biopsy; endometrial cancer; myomas; obesity; sentinel lymph node},
   language = {eng},
   issn = {0020-7292},
   journal = {INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS},
   title = {Predictors for sentinel lymph node mapping failure using indocyanine green injection in apparent early stages of endometrial cancer: A single-center prospective study},
   url = {https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.70123},
   volume = {170},
   year = {2025}
}

TY  - JOUR
ID  - 2556701
AU  - Bretová, Petra - Minář, Luboš - Ovesná, Petra - Weinberger, Vít - Felsinger, Michal - Koblížková, Michaela - Hausnerová, Jitka - Jandáková, Eva - Stupková, Tatiana
PY  - 2025
TI  - Predictors for sentinel lymph node mapping failure using indocyanine green injection in apparent early stages of endometrial cancer: A single-center prospective study
JF  - INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
VL  - 170
IS  - 3
SP  - 1214-1224
EP  - 1214-1224
PB  - Wiley
SN  - 00207292
KW  - biopsy
KW  - endometrial cancer
KW  - myomas
KW  - obesity
KW  - sentinel lymph node
UR  - https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.70123
N2  - Objective The current study aimed to analyze predictive factors of sentinel lymph node mapping failure in apparently early stages of endometrial cancer using intracervical indocyanine green injection.Methods A single-center prospective study was conducted between June 2019 and August 2023 at the Department of Gynecology and Obstetrics, University Hospital Brno, Czech Republic. All patients with apparently early stage (I or II according to FIGO [International Federation of Gynecology & Obstetrics] 2009) endometrial cancer, who were indicated for sentinel node biopsy were consecutively included. The injection of 4-6 mL of indocyanine green was applied superficially and deeply into cervical tissue at the 3- and 9-o'clock positions. Patients' clinical data, surgical characteristics, and histopathological information were recorded. Univariable and multivariable regression analyses were applied.Results A total of 225 patients were eligible during the study period. Considering bilateral and unilateral failed mapping together, the only statistically significant factors for risk of failure in univariable analysis were body mass index (BMI; P = 0.036), FIGO 2009 stage (P = 0.019), and the presence of a myoma (P = 0.017). Nevertheless, when the multivariable logistic regression analysis was applied, all factors became statistically insignificant except for myoma (P = 0.031). Regarding only bilateral mapping failure, in univariable analysis, BMI (P = 0.021) and FIGO 2009 stage (P = 0.046) were significant predictors of failure. Interestingly, multivariable logistic regression analysis revealed that in addition to BMI (P = 0.007), age (P = 0.004) was also an independent predictor of bilateral failure.Conclusions Higher BMI and age were statistically significant independent factors for bilateral sentinel node mapping failure in early-stage endometrial cancer.
ER  -

BRETOVÁ, Petra; Luboš MINÁŘ; Petra OVESNÁ; Vít WEINBERGER; Michal FELSINGER; Michaela KOBLÍŽKOVÁ; Jitka HAUSNEROVÁ; Eva JANDÁKOVÁ a Tatiana STUPKOVÁ. Predictors for sentinel lymph node mapping failure using indocyanine green injection in apparent early stages of endometrial cancer: A single-center prospective study. \textit{INTERNATIONAL JOURNAL OF GYNECOLOGY \&{}amp; OBSTETRICS}. Hoboken: Wiley, 2025, roč.~170, č.~3, s.~1214-1224. ISSN~0020-7292. Dostupné z: https://doi.org/10.1002/ijgo.70123.

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