Oral sodium hyaluronate improves skin hydration, barrier
function and signs of aging: a randomized, double-blind,
placebo-controlled trial in 150 healthy adults

J 2025

Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults

DOLECKOVA, Iva; Pavel KUSNIERIK; Vratislav BERKA; Matej SIMEK; Ilona MATEJKOVA et al.

Základní údaje

Originální název

Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults

Autoři

DOLECKOVA, Iva; Pavel KUSNIERIK; Vratislav BERKA; Matej SIMEK; Ilona MATEJKOVA; Filip PROKOPEC a Petra OVESNÁ

Vydání

Nature Scientific Reports, Berlin, NATURE RESEARCH, 2025, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.900 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Nutraceutical; Oral sodium hyaluronate; Randomized controlled trial; Skin hydration; Transepidermal water loss; Wrinkles

Štítky

14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 2. 2026 14:03, Mgr. Tereza Miškechová

Anotace

V originále

Oral hyaluronan has been reported to improve various aspects of skin physiology, but existing trials often lack methodological rigor, comprehensive outcome assessment, and diverse populations. This randomized, double-blind, placebo-controlled trial evaluated the effects of sodium hyaluronate (SH) supplementation at two daily doses on skin parameters in healthy Caucasian adults. A total of 150 participants were randomized to receive SH (1.8 MDa) at 60 mg/day (SH60), 120 mg/day (SH120), or placebo for 12 weeks. Facial hydration, transepidermal water loss (TEWL), sebum, elasticity, wrinkle depth, skin gloss, colorimetric parameters, epidermal thickness, dermal density, red areas, and pore size were assessed at baseline and monthly. Subjective skin condition was evaluated every two weeks, and components of natural moisturizing factor (NMF) in forearm skin were quantified by LC-MS/MS. SH120 significantly enhanced skin hydration and elasticity, while reducing TEWL, sebum, and periorbital wrinkle depth versus placebo. It also improved skin structure by increasing epidermal thickness, dermal density, and NMF levels. SH60 showed similar but more modest effects. No changes were observed for colorimetric parameters, red areas, pore size, or gloss. In conclusion, oral SH supplementation improved multiple aspects of skin physiology, supporting its use as a functional food ingredient with measurable benefits for skin health and healthy aging.Trial registration: ClinicalTrials.gov, NCT07065110 (retrospectively registered on 15 Jul 2025); EFSA (European Food Safety Authority) registry: EFSA202400027979 (prospectively filed on 06 Jun 2024).

Citovat

DOLECKOVA, Iva; Pavel KUSNIERIK; Vratislav BERKA; Matej SIMEK; Ilona MATEJKOVA; Filip PROKOPEC a Petra OVESNÁ. Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults. Nature Scientific Reports. Berlin: NATURE RESEARCH, 2025, roč. 16, č. 1, s. 1-17. ISSN 2045-2322. Dostupné z: https://doi.org/10.1038/s41598-025-32758-5.

@article{2556917,
   author = {Doleckova, Iva and Kusnierik, Pavel and Berka, Vratislav and Simek, Matej and Matejkova, Ilona and Prokopec, Filip and Ovesná, Petra},
   article_location = {Berlin},
   article_number = {1},
   doi = {https://doi.org/10.1038/s41598-025-32758-5},
   keywords = {Nutraceutical; Oral sodium hyaluronate; Randomized controlled trial; Skin hydration; Transepidermal water loss; Wrinkles},
   language = {eng},
   issn = {2045-2322},
   journal = {Nature Scientific Reports},
   title = {Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults},
   url = {https://www.nature.com/articles/s41598-025-32758-5},
   volume = {16},
   year = {2025}
}

TY  - JOUR
ID  - 2556917
AU  - Doleckova, Iva - Kusnierik, Pavel - Berka, Vratislav - Simek, Matej - Matejkova, Ilona - Prokopec, Filip - Ovesná, Petra
PY  - 2025
TI  - Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults
JF  - Nature Scientific Reports
VL  - 16
IS  - 1
SP  - 1-17
EP  - 1-17
PB  - NATURE RESEARCH
SN  - 20452322
KW  - Nutraceutical
KW  - Oral sodium hyaluronate
KW  - Randomized controlled trial
KW  - Skin hydration
KW  - Transepidermal water loss
KW  - Wrinkles
UR  - https://www.nature.com/articles/s41598-025-32758-5
N2  - Oral hyaluronan has been reported to improve various aspects of skin physiology, but existing trials often lack methodological rigor, comprehensive outcome assessment, and diverse populations. This randomized, double-blind, placebo-controlled trial evaluated the effects of sodium hyaluronate (SH) supplementation at two daily doses on skin parameters in healthy Caucasian adults. A total of 150 participants were randomized to receive SH (1.8 MDa) at 60 mg/day (SH60), 120 mg/day (SH120), or placebo for 12 weeks. Facial hydration, transepidermal water loss (TEWL), sebum, elasticity, wrinkle depth, skin gloss, colorimetric parameters, epidermal thickness, dermal density, red areas, and pore size were assessed at baseline and monthly. Subjective skin condition was evaluated every two weeks, and components of natural moisturizing factor (NMF) in forearm skin were quantified by LC-MS/MS. SH120 significantly enhanced skin hydration and elasticity, while reducing TEWL, sebum, and periorbital wrinkle depth versus placebo. It also improved skin structure by increasing epidermal thickness, dermal density, and NMF levels. SH60 showed similar but more modest effects. No changes were observed for colorimetric parameters, red areas, pore size, or gloss. In conclusion, oral SH supplementation improved multiple aspects of skin physiology, supporting its use as a functional food ingredient with measurable benefits for skin health and healthy aging.Trial registration: ClinicalTrials.gov, NCT07065110 (retrospectively registered on 15 Jul 2025); EFSA (European Food Safety Authority) registry: EFSA202400027979 (prospectively filed on 06 Jun 2024).
ER  -

DOLECKOVA, Iva; Pavel KUSNIERIK; Vratislav BERKA; Matej SIMEK; Ilona MATEJKOVA; Filip PROKOPEC a Petra OVESNÁ. Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults. \textit{Nature Scientific Reports}. Berlin: NATURE RESEARCH, 2025, roč.~16, č.~1, s.~1-17. ISSN~2045-2322. Dostupné z: https://doi.org/10.1038/s41598-025-32758-5.

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