Sex differences in the incidence trends of early-onset
gastrointestinal cancer―the European/Mediterranean perspective

J 2025

Sex differences in the incidence trends of early-onset gastrointestinal cancer―the European/Mediterranean perspective

BEN-AHARON, I.; N Fokter DOVNIK; M H W VAN LAARHOVEN; M G GUREN; I. BARAIBAR et al.

Základní údaje

Originální název

Sex differences in the incidence trends of early-onset gastrointestinal cancer―the European/Mediterranean perspective

Autoři

BEN-AHARON, I.; N Fokter DOVNIK; M H W VAN LAARHOVEN; M G GUREN; I. BARAIBAR; N. GORDON; T. GOSHEN-LAGO; R. VERHOEVEN; T.. SOKOP; Radka LORDICK OBERMANNOVÁ a F. LORDICK

Vydání

ESMO Gastrointestinal Oncology, AMSTERDAM, Elsevier, 2025, 2949-8198

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00143820

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

gastrointestinal cancer; pancreatic cancer; early-onset; incidence; sex; Europe

Štítky

14110811, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 2. 2026 12:07, Mgr. Tereza Miškechová

Anotace

V originále

Background: While the rising incidence of early-onset colorectal cancer has been documented worldwide, there is a paucity of data on the epidemiological changes in other gastrointestinal (GI) cancers in the young population in Europe. We sought to characterize incidence patterns of GI cancers in young patients in different European/ Mediterranean countries. Patients and methods: National cancer registries in several European countries were contacted to obtain the absolute number of GI cancer cases per age group (15-49 years) at 5-year intervals and the absolute population size for each of these age groups annually from 2008 to 2018. Data were analyzed to calculate year-to-year incidence rate change and average annual percentage change. Results: Seven countries were included in the analysis: the Czech Republic, Germany, Israel, the Netherlands, Norway, Slovenia, and Spain. Different trends were observed for different GI cancers. For colorectal cancer, all countries except Germany showed increasing incidence rates in a similar pattern for males and females. An increasing trend in pancreatic cancer was documented in the Czech Republic, more in males, and in Slovenia and Israel significantly more in females. There was a slight increase in Spain and Germany, with no difference by sex. The incidence of early-onset gastric and esophageal cancer was very low and non-rising. Conclusions: Early-onset cancers along the GI tract show different patterns in different European countries. For some types of GI tumors the incidence was fairly stable between 2008 and 2018 while some were increasing, in particular colorectal cancer in both sexes, and pancreatic cancer in females.

Citovat

BEN-AHARON, I.; N Fokter DOVNIK; M H W VAN LAARHOVEN; M G GUREN; I. BARAIBAR; N. GORDON; T. GOSHEN-LAGO; R. VERHOEVEN; T.. SOKOP; Radka LORDICK OBERMANNOVÁ a F. LORDICK. Sex differences in the incidence trends of early-onset gastrointestinal cancer―the European/Mediterranean perspective. ESMO Gastrointestinal Oncology. AMSTERDAM: Elsevier, 2025, roč. 10, December 2025, s. 1-8. ISSN 2949-8198. Dostupné z: https://doi.org/10.1016/j.esmogo.2025.100238.

@article{2557120,
   author = {BenandAharon, I. and Dovnik, N Fokter and van Laarhoven, M H W and Guren, M G and Baraibar, I. and Gordon, N. and GoshenandLago, T. and Verhoeven, R. and Sokop, T.. and Lordick Obermannová, Radka and Lordick, F.},
   article_location = {AMSTERDAM},
   article_number = {December 2025},
   doi = {https://doi.org/10.1016/j.esmogo.2025.100238},
   keywords = {gastrointestinal cancer; pancreatic cancer; early-onset; incidence; sex; Europe},
   language = {eng},
   issn = {2949-8198},
   journal = {ESMO Gastrointestinal Oncology},
   title = {Sex differences in the incidence trends of early-onset gastrointestinal cancer―the European/Mediterranean perspective},
   url = {https://www.esmogastro.org/article/S2949-8198(25)00107-4/fulltext},
   volume = {10},
   year = {2025}
}

TY  - JOUR
ID  - 2557120
AU  - Ben-Aharon, I. - Dovnik, N Fokter - van Laarhoven, M H W - Guren, M G - Baraibar, I. - Gordon, N. - Goshen-Lago, T. - Verhoeven, R. - Sokop, T.. - Lordick Obermannová, Radka - Lordick, F.
PY  - 2025
TI  - Sex differences in the incidence trends of early-onset gastrointestinal cancer―the European/Mediterranean perspective
JF  - ESMO Gastrointestinal Oncology
VL  - 10
IS  - December 2025
SP  - 1-8
EP  - 1-8
PB  - Elsevier
SN  - 29498198
KW  - gastrointestinal cancer
KW  - pancreatic cancer
KW  - early-onset
KW  - incidence
KW  - sex
KW  - Europe
UR  - https://www.esmogastro.org/article/S2949-8198(25)00107-4/fulltext
N2  - Background: While the rising incidence of early-onset colorectal cancer has been documented worldwide, there is a paucity of data on the epidemiological changes in other gastrointestinal (GI) cancers in the young population in Europe. We sought to characterize incidence patterns of GI cancers in young patients in different European/ Mediterranean countries. Patients and methods: National cancer registries in several European countries were contacted to obtain the absolute number of GI cancer cases per age group (15-49 years) at 5-year intervals and the absolute population size for each of these age groups annually from 2008 to 2018. Data were analyzed to calculate year-to-year incidence rate change and average annual percentage change. Results: Seven countries were included in the analysis: the Czech Republic, Germany, Israel, the Netherlands, Norway, Slovenia, and Spain. Different trends were observed for different GI cancers. For colorectal cancer, all countries except Germany showed increasing incidence rates in a similar pattern for males and females. An increasing trend in pancreatic cancer was documented in the Czech Republic, more in males, and in Slovenia and Israel significantly more in females. There was a slight increase in Spain and Germany, with no difference by sex. The incidence of early-onset gastric and esophageal cancer was very low and non-rising. Conclusions: Early-onset cancers along the GI tract show different patterns in different European countries. For some types of GI tumors the incidence was fairly stable between 2008 and 2018 while some were increasing, in particular colorectal cancer in both sexes, and pancreatic cancer in females.
ER  -

BEN-AHARON, I.; N Fokter DOVNIK; M H W VAN LAARHOVEN; M G GUREN; I. BARAIBAR; N. GORDON; T. GOSHEN-LAGO; R. VERHOEVEN; T.. SOKOP; Radka LORDICK OBERMANNOVÁ a F. LORDICK. Sex differences in the incidence trends of early-onset gastrointestinal cancer―the European/Mediterranean perspective. \textit{ESMO Gastrointestinal Oncology}. AMSTERDAM: Elsevier, 2025, roč.~10, December 2025, s.~1-8. ISSN~2949-8198. Dostupné z: https://doi.org/10.1016/j.esmogo.2025.100238.

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