SoutheAsTern eUrope microciRculATION (SATURATION)
registry-Design and rationale

J 2025

SoutheAsTern eUrope microciRculATION (SATURATION) registry-Design and rationale

ODANOVIC, Natalija; Konstantinos TSIOUFIS; Kyriakos DIMITRIADIS; Athanasios SAKALIDIS; Michail I PAPAFAKLIS et al.

Základní údaje

Originální název

SoutheAsTern eUrope microciRculATION (SATURATION) registry-Design and rationale

Autoři

Vydání

CARDIOVASCULAR REVASCULARIZATION MEDICINE, SAN DIEGO, ELSEVIER INC, 2025, 1553-8389

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.900 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00143821

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

INOCA; Coronary thermodilution; Microvascular angina; Vasospastic angina; Coronary flow reserve; Index of microvascular resistance

Štítky

14110211, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 2. 2026 12:14, Mgr. Tereza Miškechová

Anotace

V originále

Background: A considerable number of symptomatic patients leave the cardiac catheterization lab without a definitive diagnosis for their symptoms because no epicardial stenoses are found. The significance of disorders of coronary microvasculature and vasomotion as the cause of symptoms and signs of ischemia has only recently been appreciated. Today we have a wide spectrum of invasive coronary physiology tools but little is known about when and how these tools are used in clinical practice. Study design and methodology: SoutheAsTern eUrope microciRculATION (SATURATION) registry will study the regional practice of patient selection for coronary function testing, indications, non-invasive ischemia testing, medications, procedural aspects of invasive physiology evaluation, and treatment changes after testing. The registry is expected to include 1600 patients in participating centers in Southeastern Europe from 2024 to 2029, using the thermodilution technique for evaluation of microcirculation. Major adverse cardiovascular events as well as patientcentered outcomes such as burden of angina and quality of life using Seattle Angina Questionnaire (SAQ) and EQ5D-5L will be recorded. The study will include patients with different stages of coronary artery disease (presence of disease or degree of stenosis) to elucidate the effect of coronary microcirculation on the outcomes in this broad group. Conclusion: The registry will provide information regarding the current practice of invasive coronary physiology assessment in populations at high cardiovascular risk in Southeastern Europe. This could lead to a better understanding of coronary microvascular dysfunction and its relationship to various degrees of coronary atherosclerosis together with potential interventions that can be beneficial.

Citovat

ODANOVIC, Natalija; Konstantinos TSIOUFIS; Kyriakos DIMITRIADIS; Athanasios SAKALIDIS; Michail I PAPAFAKLIS; Periklis DAVLOUROS; Igor IVANOV; Milenko CANKOVIC; Andreas S KALOGEROPOULOS; Michalis HAMILOS; Emmanuel SIDERAS; Maayan KONIGSTEIN; Lior ZORNITZKI; Tomas KOVARNIK; Zoltan RUZSA; Zsolt PIROTH; Marija ZDRAVKOVIC; Zlatko MEHMEDBEGOVIC; Zoran MIOVSKI; Hrvoje JURIN; Jan KAŇOVSKÝ; Ehud REGEV; Samit SHAH; Ivan ILIC a SATURATION INVESTIGATORS. SoutheAsTern eUrope microciRculATION (SATURATION) registry-Design and rationale. CARDIOVASCULAR REVASCULARIZATION MEDICINE. SAN DIEGO: ELSEVIER INC, 2025, roč. 78, September 2025, s. 104-107. ISSN 1553-8389. Dostupné z: https://doi.org/10.1016/j.carrev.2024.11.012.

@article{2557121,
   author = {Odanovic, Natalija and Tsioufis, Konstantinos and Dimitriadis, Kyriakos and Sakalidis, Athanasios and Papafaklis, Michail I and Davlouros, Periklis and Ivanov, Igor and Cankovic, Milenko and Kalogeropoulos, Andreas S and Hamilos, Michalis and Sideras, Emmanuel and Konigstein, Maayan and Zornitzki, Lior and Kovarnik, Tomas and Ruzsa, Zoltan and Piroth, Zsolt and Zdravkovic, Marija and Mehmedbegovic, Zlatko and Miovski, Zoran and Jurin, Hrvoje and Kaňovský, Jan and Regev, Ehud and Shah, Samit and Ilic, Ivan and Investigators, SATURATION},
   article_location = {SAN DIEGO},
   article_number = {September 2025},
   doi = {https://doi.org/10.1016/j.carrev.2024.11.012},
   keywords = {INOCA; Coronary thermodilution; Microvascular angina; Vasospastic angina; Coronary flow reserve; Index of microvascular resistance},
   language = {eng},
   issn = {1553-8389},
   journal = {CARDIOVASCULAR REVASCULARIZATION MEDICINE},
   title = {SoutheAsTern eUrope microciRculATION (SATURATION) registry-Design and rationale},
   url = {https://www.sciencedirect.com/science/article/pii/S1553838924007413},
   volume = {78},
   year = {2025}
}

TY  - JOUR
ID  - 2557121
AU  - Odanovic, Natalija - Tsioufis, Konstantinos - Dimitriadis, Kyriakos - Sakalidis, Athanasios - Papafaklis, Michail I - Davlouros, Periklis - Ivanov, Igor - Cankovic, Milenko - Kalogeropoulos, Andreas S - Hamilos, Michalis - Sideras, Emmanuel - Konigstein, Maayan - Zornitzki, Lior - Kovarnik, Tomas - Ruzsa, Zoltan - Piroth, Zsolt - Zdravkovic, Marija - Mehmedbegovic, Zlatko - Miovski, Zoran - Jurin, Hrvoje - Kaňovský, Jan - Regev, Ehud - Shah, Samit - Ilic, Ivan - Investigators, SATURATION
PY  - 2025
TI  - SoutheAsTern eUrope microciRculATION (SATURATION) registry-Design and rationale
JF  - CARDIOVASCULAR REVASCULARIZATION MEDICINE
VL  - 78
IS  - September 2025
SP  - 104-107
EP  - 104-107
PB  - ELSEVIER INC
SN  - 15538389
KW  - INOCA
KW  - Coronary thermodilution
KW  - Microvascular angina
KW  - Vasospastic angina
KW  - Coronary flow reserve
KW  - Index of microvascular resistance
UR  - https://www.sciencedirect.com/science/article/pii/S1553838924007413
N2  - Background: A considerable number of symptomatic patients leave the cardiac catheterization lab without a definitive diagnosis for their symptoms because no epicardial stenoses are found. The significance of disorders of coronary microvasculature and vasomotion as the cause of symptoms and signs of ischemia has only recently been appreciated. Today we have a wide spectrum of invasive coronary physiology tools but little is known about when and how these tools are used in clinical practice. Study design and methodology: SoutheAsTern eUrope microciRculATION (SATURATION) registry will study the regional practice of patient selection for coronary function testing, indications, non-invasive ischemia testing, medications, procedural aspects of invasive physiology evaluation, and treatment changes after testing. The registry is expected to include 1600 patients in participating centers in Southeastern Europe from 2024 to 2029, using the thermodilution technique for evaluation of microcirculation. Major adverse cardiovascular events as well as patientcentered outcomes such as burden of angina and quality of life using Seattle Angina Questionnaire (SAQ) and EQ5D-5L will be recorded. The study will include patients with different stages of coronary artery disease (presence of disease or degree of stenosis) to elucidate the effect of coronary microcirculation on the outcomes in this broad group. Conclusion: The registry will provide information regarding the current practice of invasive coronary physiology assessment in populations at high cardiovascular risk in Southeastern Europe. This could lead to a better understanding of coronary microvascular dysfunction and its relationship to various degrees of coronary atherosclerosis together with potential interventions that can be beneficial.
ER  -

ODANOVIC, Natalija; Konstantinos TSIOUFIS; Kyriakos DIMITRIADIS; Athanasios SAKALIDIS; Michail I PAPAFAKLIS; Periklis DAVLOUROS; Igor IVANOV; Milenko CANKOVIC; Andreas S KALOGEROPOULOS; Michalis HAMILOS; Emmanuel SIDERAS; Maayan KONIGSTEIN; Lior ZORNITZKI; Tomas KOVARNIK; Zoltan RUZSA; Zsolt PIROTH; Marija ZDRAVKOVIC; Zlatko MEHMEDBEGOVIC; Zoran MIOVSKI; Hrvoje JURIN; Jan KAŇOVSKÝ; Ehud REGEV; Samit SHAH; Ivan ILIC a SATURATION INVESTIGATORS. SoutheAsTern eUrope microciRculATION (SATURATION) registry-Design and rationale. \textit{CARDIOVASCULAR REVASCULARIZATION MEDICINE}. SAN DIEGO: ELSEVIER INC, 2025, roč.~78, September 2025, s.~104-107. ISSN~1553-8389. Dostupné z: https://doi.org/10.1016/j.carrev.2024.11.012.

Přehled o publikaci