Increased pre-alpha functional connectivity in dementia with
Lewy bodies

J 2025

Increased pre-alpha functional connectivity in dementia with Lewy bodies

D'ANSELMO, Anita; Giulia PRETE; Di Crosta ADOLFO; Lucrezia BRISTOT; Claudia CARRARINI et al.

Základní údaje

Originální název

Increased pre-alpha functional connectivity in dementia with Lewy bodies

Autoři

Vydání

Journal of Alzheimers Disease, London, SAGE PUBLICATIONS, 2025, 1387-2877

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.100 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Alzheimer's disease; dementia with Lewy bodies; frequency bands; functional brain connectivity; resting-state EEG

Štítky

14110127, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 3. 2026 14:39, Mgr. Tereza Miškechová

Anotace

V originále

Background Resting-state EEG studies have shown that neurodegenerative dementias like Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) can alter cortical functional connectivity. In DLB, the presence of a pre-alpha rhythm suggests frequency-specific network dysfunctions that remain poorly understood.Objective In the present study we tested the hypothesis that electroencephalography (EEG) recordings in DLB patients may show abnormal cortical functional connectivity.Methods Resting-state EEG activity was recorded in 73 DLB, 70 AD, and 41 healthy control (HC) participants from seven European DLB Consortium Centers. We used eLORETA to calculate lagged linear connectivity (LLC) from EEG sources at delta, theta, pre-alpha, alpha, beta, gamma bands.Results Statistical analyses revealed greater fronto-occipital connectivity at the theta and pre-alpha bands in the DLB group compared to the AD and HC groups. Furthermore, the DLB and AD groups displayed reduced alpha LLC compared to the HC group.Conclusions The results suggest that in DLB patients, resting-state EEG pre-alpha activity is not a local process. Instead, it may reflect enhanced functional connectivity, possibly propagating dysfunctional thalamocortical connectivity, within long fronto-occipital tracts.

Návaznosti

LX22NPO5107, projekt VaV

Název: Národní ústav pro neurologický výzkum

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní ústav pro neurologický výzkum, 5.1 EXCELES

NU20-04-00294, projekt VaV

Název: Diagnostika onemocnění s Lewyho tělísky v prodromálním stadiu založená na analýze multimodálních dat

Investor: Ministerstvo zdravotnictví ČR, Diagnostika onemocnění s Lewyho tělísky v prodromálním stadiu založená na analýze multimodálních dat

Citovat

D'ANSELMO, Anita; Giulia PRETE; Di Crosta ADOLFO; Lucrezia BRISTOT; Claudia CARRARINI; Alberto JARAMILLO-JIMENEZ; Rocco PALUMBO; Sara VARANESE; Andrea PILOTTO; Matteo PARDINI; Dario ARNALDI; Fabrizia D'ANTONIO; David ONDRÁČEK; Michele TINAZZI; Irena REKTOROVÁ; Milica KRAMBERGER; John-Paul TAYLOR; Simona LUZZI; Giuseppe BRUNO; Claudio BABILONI; Alessandro PADOVANI; Dag AARSLAND; Nicola MAMMARELLA; Di Domenico ALBERTO; Luca TOMMASI a Laura BONANNI. Increased pre-alpha functional connectivity in dementia with Lewy bodies. Journal of Alzheimers Disease. London: SAGE PUBLICATIONS, 2025, roč. 108, č. 3, s. 1132-1143. ISSN 1387-2877. Dostupné z: https://doi.org/10.1177/13872877251385424.

@article{2558038,
   author = {D'Anselmo, Anita and Prete, Giulia and Adolfo, Di Crosta and Bristot, Lucrezia and Carrarini, Claudia and JaramilloandJimenez, Alberto and Palumbo, Rocco and Varanese, Sara and Pilotto, Andrea and Pardini, Matteo and Arnaldi, Dario and D'Antonio, Fabrizia and Ondráček, David and Tinazzi, Michele and Rektorová, Irena and Kramberger, Milica and Taylor, JohnandPaul and Luzzi, Simona and Bruno, Giuseppe and Babiloni, Claudio and Padovani, Alessandro and Aarsland, Dag and Mammarella, Nicola and Alberto, Di Domenico and Tommasi, Luca and Bonanni, Laura},
   article_location = {London},
   article_number = {3},
   doi = {https://doi.org/10.1177/13872877251385424},
   keywords = {Alzheimer's disease; dementia with Lewy bodies; frequency bands; functional brain connectivity; resting-state EEG},
   language = {eng},
   issn = {1387-2877},
   journal = {Journal of Alzheimers Disease},
   title = {Increased pre-alpha functional connectivity in dementia with Lewy bodies},
   url = {https://journals.sagepub.com/doi/10.1177/13872877251385424},
   volume = {108},
   year = {2025}
}

TY  - JOUR
ID  - 2558038
AU  - D'Anselmo, Anita - Prete, Giulia - Adolfo, Di Crosta - Bristot, Lucrezia - Carrarini, Claudia - Jaramillo-Jimenez, Alberto - Palumbo, Rocco - Varanese, Sara - Pilotto, Andrea - Pardini, Matteo - Arnaldi, Dario - D'Antonio, Fabrizia - Ondráček, David - Tinazzi, Michele - Rektorová, Irena - Kramberger, Milica - Taylor, John-Paul - Luzzi, Simona - Bruno, Giuseppe - Babiloni, Claudio - Padovani, Alessandro - Aarsland, Dag - Mammarella, Nicola - Alberto, Di Domenico - Tommasi, Luca - Bonanni, Laura
PY  - 2025
TI  - Increased pre-alpha functional connectivity in dementia with Lewy bodies
JF  - Journal of Alzheimers Disease
VL  - 108
IS  - 3
SP  - 1132-1143
EP  - 1132-1143
PB  - SAGE PUBLICATIONS
SN  - 13872877
KW  - Alzheimer's disease
KW  - dementia with Lewy bodies
KW  - frequency bands
KW  - functional brain connectivity
KW  - resting-state EEG
UR  - https://journals.sagepub.com/doi/10.1177/13872877251385424
N2  - Background Resting-state EEG studies have shown that neurodegenerative dementias like Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) can alter cortical functional connectivity. In DLB, the presence of a pre-alpha rhythm suggests frequency-specific network dysfunctions that remain poorly understood.Objective In the present study we tested the hypothesis that electroencephalography (EEG) recordings in DLB patients may show abnormal cortical functional connectivity.Methods Resting-state EEG activity was recorded in 73 DLB, 70 AD, and 41 healthy control (HC) participants from seven European DLB Consortium Centers. We used eLORETA to calculate lagged linear connectivity (LLC) from EEG sources at delta, theta, pre-alpha, alpha, beta, gamma bands.Results Statistical analyses revealed greater fronto-occipital connectivity at the theta and pre-alpha bands in the DLB group compared to the AD and HC groups. Furthermore, the DLB and AD groups displayed reduced alpha LLC compared to the HC group.Conclusions The results suggest that in DLB patients, resting-state EEG pre-alpha activity is not a local process. Instead, it may reflect enhanced functional connectivity, possibly propagating dysfunctional thalamocortical connectivity, within long fronto-occipital tracts.
ER  -

D'ANSELMO, Anita; Giulia PRETE; Di Crosta ADOLFO; Lucrezia BRISTOT; Claudia CARRARINI; Alberto JARAMILLO-JIMENEZ; Rocco PALUMBO; Sara VARANESE; Andrea PILOTTO; Matteo PARDINI; Dario ARNALDI; Fabrizia D'ANTONIO; David ONDRÁČEK; Michele TINAZZI; Irena REKTOROVÁ; Milica KRAMBERGER; John-Paul TAYLOR; Simona LUZZI; Giuseppe BRUNO; Claudio BABILONI; Alessandro PADOVANI; Dag AARSLAND; Nicola MAMMARELLA; Di Domenico ALBERTO; Luca TOMMASI a Laura BONANNI. Increased pre-alpha functional connectivity in dementia with Lewy bodies. \textit{Journal of Alzheimers Disease}. London: SAGE PUBLICATIONS, 2025, roč.~108, č.~3, s.~1132-1143. ISSN~1387-2877. Dostupné z: https://doi.org/10.1177/13872877251385424.

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