Outcome of patients with curative-intent treatment for primary
pulmonary sarcoma: Results from an international multicenter
retrospective study

J 2025

Outcome of patients with curative-intent treatment for primary pulmonary sarcoma: Results from an international multicenter retrospective study

COLLAUD, Stephane; Theresa STORK; Dagmar ADÁMKOVÁ; Clemens AIGNER; Ivan BRAVIO et al.

Základní údaje

Originální název

Outcome of patients with curative-intent treatment for primary pulmonary sarcoma: Results from an international multicenter retrospective study

Autoři

Vydání

JTCVS OPEN, AMSTERDAM, ELSEVIER, 2025, 2666-2736

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.900 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

primary pulmonary sarcoma; surgery; EURACAN; chemotherapy; radiotherapy; outcome; soft-tissue sarcoma

Štítky

14110811, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 3. 2026 12:29, Mgr. Tereza Miškechová

Anotace

V originále

Objective: To evaluate outcome and prognostic factors of patients with primary pulmonary sarcoma (PPS) who underwent curative-intent surgery within multimodality treatment. Methods: An international, multicenter, retrospective study including patients with PPS was performed through a network of sarcoma experts. Data on demographics, staging, treatment, and outcomes were retrieved. Overall survival was calculated from the date of diagnosis. Prognostic factors were assessed using uni-and multivariate analysis. Results: Eighteen centers from 9 countries contributed, for a total of 173 patients. One hundred fifteen patients (66%) underwent curative-intent surgery within multimodality treatment. There were 58 male patients (50%). Twenty-two patients (20%) had metastases, mainly to lung (n = 7, 30%) and pleura (n = 9, 39%). Thirty-three patients (30%) underwent preoperative chemotherapy. Extent of lung resection was sublobar (n = 11, 10%), lobar (n = 58, 54%), or bilobar/pneumonectomy (n = 39, 36%). Median tumor size was 85 mm. Sixty-nine patients had grade 3 tumors (71%). Resection was complete in 85 patients (75%). Lymphadenectomy was performed in 70 patients (63%), with nodal involvement in 10 (14%). Thirty-seven (37%) patients received adjuvant chemotherapy, and 27 (27%) patients received adjuvant radiotherapy. Overall survival was 49% and 31% at 5 and 10 years, respectively. Median follow-up was 33 months. Male gender (P = .003), age older than 60 years (P = .021), presence of metastasis (P = . 002), tumor size >40 mm (P = . 046), and incomplete resections (P = . 008) were independent prognostic factors for poor survival. Conclusions: In patients with curative-intent multimodal treatment for PPS, an encouraging 5-year survival rate of 49% can be achieved in expert centers. Independent prognostic factors may aid in selecting patients for curative treatment. (JTCVS Open 2025;28:565-73)

Citovat

COLLAUD, Stephane; Theresa STORK; Dagmar ADÁMKOVÁ; Clemens AIGNER; Ivan BRAVIO; Antonella BRUNELLO; Luigi CERBONE; Hugo CLERMIDY; De Cock LORE; Silvia GASPERONI; Nicolas GIRARD; Anna MARIUK-JAREMA; Rolf LEFERING; Enrico MELIS; Gloria MARQUINA; Filomena MAZZEO; Iurii MYKOLIUK; Maria A PANTALEO; Nicolas PENEL; Hans-Ulrich SCHILDHAUS; Sabino STRIPPOLI; Bruno VINCENZI; Sarah WATSON; Jean-Yves BLAY a Sebastian BAUER. Outcome of patients with curative-intent treatment for primary pulmonary sarcoma: Results from an international multicenter retrospective study. JTCVS OPEN. AMSTERDAM: ELSEVIER, 2025, roč. 28, December 2025, s. 565-573. ISSN 2666-2736. Dostupné z: https://doi.org/10.1016/j.xjon.2025.06.024.

@article{2558044,
   author = {Collaud, Stephane and Stork, Theresa and Adámková, Dagmar and Aigner, Clemens and Bravio, Ivan and Brunello, Antonella and Cerbone, Luigi and Clermidy, Hugo and Lore, De Cock and Gasperoni, Silvia and Girard, Nicolas and MariukandJarema, Anna and Lefering, Rolf and Melis, Enrico and Marquina, Gloria and Mazzeo, Filomena and Mykoliuk, Iurii and Pantaleo, Maria A and Penel, Nicolas and Schildhaus, HansandUlrich and Strippoli, Sabino and Vincenzi, Bruno and Watson, Sarah and Blay, JeanandYves and Bauer, Sebastian},
   article_location = {AMSTERDAM},
   article_number = {December 2025},
   doi = {https://doi.org/10.1016/j.xjon.2025.06.024},
   keywords = {primary pulmonary sarcoma; surgery; EURACAN; chemotherapy; radiotherapy; outcome; soft-tissue sarcoma},
   language = {eng},
   issn = {2666-2736},
   journal = {JTCVS OPEN},
   title = {Outcome of patients with curative-intent treatment for primary pulmonary sarcoma: Results from an international multicenter retrospective study},
   url = {https://www.sciencedirect.com/science/article/pii/S2666273625003237},
   volume = {28},
   year = {2025}
}

TY  - JOUR
ID  - 2558044
AU  - Collaud, Stephane - Stork, Theresa - Adámková, Dagmar - Aigner, Clemens - Bravio, Ivan - Brunello, Antonella - Cerbone, Luigi - Clermidy, Hugo - Lore, De Cock - Gasperoni, Silvia - Girard, Nicolas - Mariuk-Jarema, Anna - Lefering, Rolf - Melis, Enrico - Marquina, Gloria - Mazzeo, Filomena - Mykoliuk, Iurii - Pantaleo, Maria A - Penel, Nicolas - Schildhaus, Hans-Ulrich - Strippoli, Sabino - Vincenzi, Bruno - Watson, Sarah - Blay, Jean-Yves - Bauer, Sebastian
PY  - 2025
TI  - Outcome of patients with curative-intent treatment for primary pulmonary sarcoma: Results from an international multicenter retrospective study
JF  - JTCVS OPEN
VL  - 28
IS  - December 2025
SP  - 565-573
EP  - 565-573
PB  - ELSEVIER
SN  - 26662736
KW  - primary pulmonary sarcoma
KW  - surgery
KW  - EURACAN
KW  - chemotherapy
KW  - radiotherapy
KW  - outcome
KW  - soft-tissue sarcoma
UR  - https://www.sciencedirect.com/science/article/pii/S2666273625003237
N2  - Objective: To evaluate outcome and prognostic factors of patients with primary pulmonary sarcoma (PPS) who underwent curative-intent surgery within multimodality treatment. Methods: An international, multicenter, retrospective study including patients with PPS was performed through a network of sarcoma experts. Data on demographics, staging, treatment, and outcomes were retrieved. Overall survival was calculated from the date of diagnosis. Prognostic factors were assessed using uni-and multivariate analysis. Results: Eighteen centers from 9 countries contributed, for a total of 173 patients. One hundred fifteen patients (66%) underwent curative-intent surgery within multimodality treatment. There were 58 male patients (50%). Twenty-two patients (20%) had metastases, mainly to lung (n = 7, 30%) and pleura (n = 9, 39%). Thirty-three patients (30%) underwent preoperative chemotherapy. Extent of lung resection was sublobar (n = 11, 10%), lobar (n = 58, 54%), or bilobar/pneumonectomy (n = 39, 36%). Median tumor size was 85 mm. Sixty-nine patients had grade 3 tumors (71%). Resection was complete in 85 patients (75%). Lymphadenectomy was performed in 70 patients (63%), with nodal involvement in 10 (14%). Thirty-seven (37%) patients received adjuvant chemotherapy, and 27 (27%) patients received adjuvant radiotherapy. Overall survival was 49% and 31% at 5 and 10 years, respectively. Median follow-up was 33 months. Male gender (P = .003), age older than 60 years (P = .021), presence of metastasis (P = . 002), tumor size >40 mm (P = . 046), and incomplete resections (P = . 008) were independent prognostic factors for poor survival. Conclusions: In patients with curative-intent multimodal treatment for PPS, an encouraging 5-year survival rate of 49% can be achieved in expert centers. Independent prognostic factors may aid in selecting patients for curative treatment. (JTCVS Open 2025;28:565-73)
ER  -

COLLAUD, Stephane; Theresa STORK; Dagmar ADÁMKOVÁ; Clemens AIGNER; Ivan BRAVIO; Antonella BRUNELLO; Luigi CERBONE; Hugo CLERMIDY; De Cock LORE; Silvia GASPERONI; Nicolas GIRARD; Anna MARIUK-JAREMA; Rolf LEFERING; Enrico MELIS; Gloria MARQUINA; Filomena MAZZEO; Iurii MYKOLIUK; Maria A PANTALEO; Nicolas PENEL; Hans-Ulrich SCHILDHAUS; Sabino STRIPPOLI; Bruno VINCENZI; Sarah WATSON; Jean-Yves BLAY a Sebastian BAUER. Outcome of patients with curative-intent treatment for primary pulmonary sarcoma: Results from an international multicenter retrospective study. \textit{JTCVS OPEN}. AMSTERDAM: ELSEVIER, 2025, roč.~28, December 2025, s.~565-573. ISSN~2666-2736. Dostupné z: https://doi.org/10.1016/j.xjon.2025.06.024.

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