Structure activity relationship of flavonoids as PPARγ agonists

J 2025

Structure activity relationship of flavonoids as PPARγ agonists

TREML, Jakub; Daniela NYKODÝMOVÁ a Peter KUBATKA

Základní údaje

Originální název

Structure activity relationship of flavonoids as PPARγ agonists

Autoři

TREML, Jakub; Daniela NYKODÝMOVÁ a Peter KUBATKA

Vydání

Phytochemistry reviews, Dordrecht, Springer, 2025, 1568-7767

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.600 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14160/25:00143917

Organizační jednotka

Farmaceutická fakulta

Klíčová slova anglicky

Flavonoids; Isoflavones; Diabetes mellitus; PPAR gamma

Štítky

rivok, ÚMF

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 3. 2026 22:20, Mgr. Irena Doubková

Anotace

V originále

Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a transcriptional factor and key regulatory element in glucose and lipid metabolism. We have attempted to determine the structure-activity relationship between flavonoids as PPAR gamma agonists through a literature search. To compare results from different studies and methods, we have recalculated them to the percentage of positive control (%PC). We have also described various methods used to determine PPAR gamma agonists. The most promising PPAR gamma agonists are isoflavones, namely 4'-fluoro-7-hydroxyisoflavone (4; %PC = 710.3%). The results presented in this review could be used for further semisynthetic modifications of flavonoids to enhance their PPAR gamma agonistic activity.

Citovat

TREML, Jakub; Daniela NYKODÝMOVÁ a Peter KUBATKA. Structure activity relationship of flavonoids as PPARγ agonists. Phytochemistry reviews. Dordrecht: Springer, 2025, roč. 24, č. 5, s. 3797-3827. ISSN 1568-7767. Dostupné z: https://doi.org/10.1007/s11101-025-10121-w.

@article{2558617,
   author = {Treml, Jakub and Nykodýmová, Daniela and Kubatka, Peter},
   article_location = {Dordrecht},
   article_number = {5},
   doi = {https://doi.org/10.1007/s11101-025-10121-w},
   keywords = {Flavonoids; Isoflavones; Diabetes mellitus; PPAR gamma},
   language = {eng},
   issn = {1568-7767},
   journal = {Phytochemistry reviews},
   title = {Structure activity relationship of flavonoids as PPARγ agonists},
   url = {https://link.springer.com/article/10.1007/s11101-025-10121-w?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot&getft_integrator=clarivate},
   volume = {24},
   year = {2025}
}

TY  - JOUR
ID  - 2558617
AU  - Treml, Jakub - Nykodýmová, Daniela - Kubatka, Peter
PY  - 2025
TI  - Structure activity relationship of flavonoids as PPARγ agonists
JF  - Phytochemistry reviews
VL  - 24
IS  - 5
SP  - 3797-3827
EP  - 3797-3827
PB  - Springer
SN  - 15687767
KW  - Flavonoids
KW  - Isoflavones
KW  - Diabetes mellitus
KW  - PPAR gamma
UR  - https://link.springer.com/article/10.1007/s11101-025-10121-w?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot&getft_integrator=clarivate
N2  - Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a transcriptional factor and key regulatory element in glucose and lipid metabolism. We have attempted to determine the structure-activity relationship between flavonoids as PPAR gamma agonists through a literature search. To compare results from different studies and methods, we have recalculated them to the percentage of positive control (%PC). We have also described various methods used to determine PPAR gamma agonists. The most promising PPAR gamma agonists are isoflavones, namely 4'-fluoro-7-hydroxyisoflavone (4; %PC = 710.3%). The results presented in this review could be used for further semisynthetic modifications of flavonoids to enhance their PPAR gamma agonistic activity.
ER  -

TREML, Jakub; Daniela NYKODÝMOVÁ a Peter KUBATKA. Structure activity relationship of flavonoids as PPARγ agonists. \textit{Phytochemistry reviews}. Dordrecht: Springer, 2025, roč.~24, č.~5, s.~3797-3827. ISSN~1568-7767. Dostupné z: https://doi.org/10.1007/s11101-025-10121-w.

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