Rapid Determination of Nimesulide by Capillary Zone
Electrophoresis in Various Pharmaceutical Formulations

J 2025

Rapid Determination of Nimesulide by Capillary Zone Electrophoresis in Various Pharmaceutical Formulations

HO, Claudia a Jiří PAZOUREK

Základní údaje

Originální název

Rapid Determination of Nimesulide by Capillary Zone Electrophoresis in Various Pharmaceutical Formulations

Autoři

HO, Claudia a Jiří PAZOUREK

Vydání

SEPARATIONS, BASEL, MDPI, 2025, 2297-8739

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10406 Analytical chemistry

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.700 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14160/25:00143905

Organizační jednotka

Farmaceutická fakulta

Klíčová slova anglicky

CZE; gel; nimesulide; NSAID; rapid determination; tablets; sachets

Štítky

rivok, ÚChL

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 3. 2026 21:00, Mgr. Irena Doubková

Anotace

V originále

Nimesulide is a popular non-steroidal anti-inflammatory drug (NSAID) and a cyclooxygenase-2 inhibitor available in more than 50 countries worldwide. A rapid and simple method for nimesulide determination is presented. Experimental parameters based on a previously published work were revised and adopted into a method with significantly better performance: pH was shifted from 8.10 to 9.25, borate background electrolyte concentration from 10 to 60 mM-resulting in a run time less than 4 min, and number of theoretical plates greater than 100,000. The method was validated and applied for the determination of nimesulide in three formulations with the active substance of nimesulide: tablets, gel, and powder (in sachets for oral suspension). Also, the tablets were tested for uniformity of content of single-dose preparations according to Ph. Eur.

Citovat

HO, Claudia a Jiří PAZOUREK. Rapid Determination of Nimesulide by Capillary Zone Electrophoresis in Various Pharmaceutical Formulations. SEPARATIONS. BASEL: MDPI, 2025, roč. 12, č. 5, s. 1-14. ISSN 2297-8739. Dostupné z: https://doi.org/10.3390/separations12050132.

@article{2558961,
   author = {Ho, Claudia and Pazourek, Jiří},
   article_location = {BASEL},
   article_number = {5},
   doi = {https://doi.org/10.3390/separations12050132},
   keywords = {CZE; gel; nimesulide; NSAID; rapid determination; tablets; sachets},
   language = {eng},
   issn = {2297-8739},
   journal = {SEPARATIONS},
   title = {Rapid Determination of Nimesulide by Capillary Zone Electrophoresis in Various Pharmaceutical Formulations},
   url = {https://www.mdpi.com/2297-8739/12/5/132},
   volume = {12},
   year = {2025}
}

TY  - JOUR
ID  - 2558961
AU  - Ho, Claudia - Pazourek, Jiří
PY  - 2025
TI  - Rapid Determination of Nimesulide by Capillary Zone Electrophoresis in Various Pharmaceutical Formulations
JF  - SEPARATIONS
VL  - 12
IS  - 5
SP  - 1-14
EP  - 1-14
PB  - MDPI
SN  - 22978739
KW  - CZE
KW  - gel
KW  - nimesulide
KW  - NSAID
KW  - rapid determination
KW  - tablets
KW  - sachets
UR  - https://www.mdpi.com/2297-8739/12/5/132
N2  - Nimesulide is a popular non-steroidal anti-inflammatory drug (NSAID) and a cyclooxygenase-2 inhibitor available in more than 50 countries worldwide. A rapid and simple method for nimesulide determination is presented. Experimental parameters based on a previously published work were revised and adopted into a method with significantly better performance: pH was shifted from 8.10 to 9.25, borate background electrolyte concentration from 10 to 60 mM-resulting in a run time less than 4 min, and number of theoretical plates greater than 100,000. The method was validated and applied for the determination of nimesulide in three formulations with the active substance of nimesulide: tablets, gel, and powder (in sachets for oral suspension). Also, the tablets were tested for uniformity of content of single-dose preparations according to Ph. Eur.
ER  -

HO, Claudia a Jiří PAZOUREK. Rapid Determination of Nimesulide by Capillary Zone Electrophoresis in Various Pharmaceutical Formulations. \textit{SEPARATIONS}. BASEL: MDPI, 2025, roč.~12, č.~5, s.~1-14. ISSN~2297-8739. Dostupné z: https://doi.org/10.3390/separations12050132.

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