Experimental ultrasound stimulator for improving the diffusion
of exosomes and drugs into lung tissue

J 2025

Experimental ultrasound stimulator for improving the diffusion of exosomes and drugs into lung tissue

PRUCHA, Jaroslav; Josef SKOPALIK; Tomáš PARÁK; Petr BRATKA; Julie CUPROVA et al.

Základní údaje

Originální název

Experimental ultrasound stimulator for improving the diffusion of exosomes and drugs into lung tissue

Autoři

PRUCHA, Jaroslav; Josef SKOPALIK; Tomáš PARÁK; Petr BRATKA a Julie CUPROVA

Vydání

Veterinarni Medicina, Prague, CZECH ACAD AGRIC SCI, 2025, 0375-8427

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

40300 4.3 Veterinary science

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 0.800 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14160/25:00143922

Organizační jednotka

Farmaceutická fakulta

Klíčová slova anglicky

drug infusion; electromagnetic stimulus; exosomes; fibrosis; therapeutic ultrasound

Štítky

rivok, ÚFTo

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 3. 2026 11:07, Mgr. Irena Doubková

Anotace

V originále

Pulmonary fibrosis is not only a consequence of the recent COVID-19 pandemic, but is increasingly recognised by both human and veterinary healthcare providers. Pulmonary fibrosis is a progressive condition that leads to a decline in respiratory function and even death. In this work, we compared MSC-derived exosomes with conventional anti-inflammatory drug treatments. Exosomes from stimulated MSCs displayed higher miRNA concentrations (in particular, miRNA-30b was significantly increased). A set of rats with induced lung fibrosis were divided into four groups: NC (control - no treatment), A2 (exosome infusion), A3 (exosome infusion combined with ultrasound stimulation), and F1 (tamoxifen/metfor min drug treatment). The rats' lungs were subjected to histological analysis; the fibrosis scores for groups F1 and A3 were very similar and decreased significantly compared with group NC. Ultrasound-facilitated diffusion of exosomes from the capillaries into the lung tissue could represent an innovative therapeutic approach for slowing fibrosis and prolonging the active life of the organism.

Citovat

PRUCHA, Jaroslav; Josef SKOPALIK; Tomáš PARÁK; Petr BRATKA a Julie CUPROVA. Experimental ultrasound stimulator for improving the diffusion of exosomes and drugs into lung tissue. Veterinarni Medicina. Prague: CZECH ACAD AGRIC SCI, 2025, roč. 70, č. 11, s. 417-426. ISSN 0375-8427. Dostupné z: https://doi.org/10.17221/41/2025-VETMED.

@article{2559446,
   author = {Prucha, Jaroslav and Skopalik, Josef and Parák, Tomáš and Bratka, Petr and Cuprova, Julie},
   article_location = {Prague},
   article_number = {11},
   doi = {https://doi.org/10.17221/41/2025-VETMED},
   keywords = {drug infusion; electromagnetic stimulus; exosomes; fibrosis; therapeutic ultrasound},
   language = {eng},
   issn = {0375-8427},
   journal = {Veterinarni Medicina},
   title = {Experimental ultrasound stimulator for improving the diffusion of exosomes and drugs into lung tissue},
   url = {https://vetmed.agriculturejournals.cz/artkey/vet-202511-0003_experimental-ultrasound-stimulator-for-improving-the-diffusion-of-exosomes-and-drugs-into-lung-tissue.php},
   volume = {70},
   year = {2025}
}

TY  - JOUR
ID  - 2559446
AU  - Prucha, Jaroslav - Skopalik, Josef - Parák, Tomáš - Bratka, Petr - Cuprova, Julie
PY  - 2025
TI  - Experimental ultrasound stimulator for improving the diffusion of exosomes and drugs into lung tissue
JF  - Veterinarni Medicina
VL  - 70
IS  - 11
SP  - 417-426
EP  - 417-426
PB  - CZECH ACAD AGRIC SCI
SN  - 03758427
KW  - drug infusion
KW  - electromagnetic stimulus
KW  - exosomes
KW  - fibrosis
KW  - therapeutic ultrasound
UR  - https://vetmed.agriculturejournals.cz/artkey/vet-202511-0003_experimental-ultrasound-stimulator-for-improving-the-diffusion-of-exosomes-and-drugs-into-lung-tissue.php
N2  - Pulmonary fibrosis is not only a consequence of the recent COVID-19 pandemic, but is increasingly recognised by both human and veterinary healthcare providers. Pulmonary fibrosis is a progressive condition that leads to a decline in respiratory function and even death. In this work, we compared MSC-derived exosomes with conventional anti-inflammatory drug treatments. Exosomes from stimulated MSCs displayed higher miRNA concentrations (in particular, miRNA-30b was significantly increased). A set of rats with induced lung fibrosis were divided into four groups: NC (control - no treatment), A2 (exosome infusion), A3 (exosome infusion combined with ultrasound stimulation), and F1 (tamoxifen/metfor min drug treatment). The rats' lungs were subjected to histological analysis; the fibrosis scores for groups F1 and A3 were very similar and decreased significantly compared with group NC. Ultrasound-facilitated diffusion of exosomes from the capillaries into the lung tissue could represent an innovative therapeutic approach for slowing fibrosis and prolonging the active life of the organism.
ER  -

PRUCHA, Jaroslav; Josef SKOPALIK; Tomáš PARÁK; Petr BRATKA a Julie CUPROVA. Experimental ultrasound stimulator for improving the diffusion of exosomes and drugs into lung tissue. \textit{Veterinarni Medicina}. Prague: CZECH ACAD AGRIC SCI, 2025, roč.~70, č.~11, s.~417-426. ISSN~0375-8427. Dostupné z: https://doi.org/10.17221/41/2025-VETMED.

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