Interindividual Variability in Duration of Action of Rocuronium
in Paediatric Patients (DurAct): A Prospective Observational
Study

J 2026

Interindividual Variability in Duration of Action of Rocuronium in Paediatric Patients (DurAct): A Prospective Observational Study

SZTURZOVÁ, Kateřina; Hana ZELINKOVÁ; Lenka KNOPPOVÁ; Michaela ŤOUKÁLKOVÁ; Tereza KRAMPLOVÁ et al.

Základní údaje

Originální název

Interindividual Variability in Duration of Action of Rocuronium in Paediatric Patients (DurAct): A Prospective Observational Study

Autoři

SZTURZOVÁ, Kateřina; Hana ZELINKOVÁ; Lenka KNOPPOVÁ; Michaela ŤOUKÁLKOVÁ; Tereza KRAMPLOVÁ; Marek KOVÁŘ ; Jozef KLUČKA a Petr ŠTOURAČ

Vydání

CHILDREN-BASEL, BASEL, MDPI, 2026, 2227-9067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30223 Anaesthesiology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.100 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

general anaesthesia; surgery; non-depolarizing neuromuscular blockers; rocuronium; sugammadex; train of four

Štítky

14110322, 14110528, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 4. 2026 13:07, Mgr. Tereza Miškechová

Anotace

V originále

Highlights What are the main findings? Time to return of TOF 1 did not differ significantly across paediatric age groups. No association between TOF recovery time and sex, weight, height, or body temperature was found. What are the implications of the main findings? The observed high interindividual variability in rocuronium duration, unrelated to patient factors, calls for individualized dosing and strict neuromuscular monitoring in paediatric patients.Highlights What are the main findings? Time to return of TOF 1 did not differ significantly across paediatric age groups. No association between TOF recovery time and sex, weight, height, or body temperature was found. What are the implications of the main findings? The observed high interindividual variability in rocuronium duration, unrelated to patient factors, calls for individualized dosing and strict neuromuscular monitoring in paediatric patients.Abstract Background: In adult patients, rocuronium shows interindividual variability related to weight, sex, and age, but paediatric data are limited. This study aimed to evaluate clinical factors influencing the duration of action of rocuronium in children. Methods: Patients aged between 0 and 18 years undergoing planned general anaesthesia were eligible. The primary objective was to compare the duration of clinical action of rocuronium after a single dose, measured until the return of TOF (Train of Four) 1, across three-group age categories. Secondary objectives explored the relationship between TOF recovery and sex, weight, height, initial body temperature, as well as the occurrence of postoperative complications related to general anaesthesia. Results: Among 96 analysed patients, no clinically relevant association was found between the duration of rocuronium action and the studied clinical factors. TOF 1 occurred at 18.1 +/- 9.5 min in those aged 1 to 5 years (n = 26), 16.8 +/- 14.5 min in those aged 6 to 10 years (n = 33), and 18.2 +/- 13.8 min in those aged 10 to 17 years (n = 37), p = 0.626. A post hoc analysis revealed high variability in recovery times across TOF levels, both in the per-protocol population (e.g., TOF 1: 17.7 +/- 12.9 min) and in patients who did not receive sugammadex. Conclusions: In paediatric patients, the duration of rocuronium action after a single dose demonstrated substantial interindividual variability, which was not explained by age, sex, weight, height, or body temperature.

Návaznosti

MUNI/A/1781/2025, interní kód MU

Název: Rozvoj vědeckých aspektů simulačního vzdělávání na LF MU III.

Investor: Masarykova univerzita, Rozvoj vědeckých aspektů simulačního vzdělávání na LF MU III.

MUNI/A/1831/2025, interní kód MU

Název: Optimalizace bezpečnosti intenzivní a perioperační péče IV

Investor: Masarykova univerzita, Optimalizace bezpečnosti intenzivní a perioperační péče IV

Citovat

SZTURZOVÁ, Kateřina; Hana ZELINKOVÁ; Lenka KNOPPOVÁ; Michaela ŤOUKÁLKOVÁ; Tereza KRAMPLOVÁ; Marek KOVÁŘ; Jozef KLUČKA a Petr ŠTOURAČ. Interindividual Variability in Duration of Action of Rocuronium in Paediatric Patients (DurAct): A Prospective Observational Study. CHILDREN-BASEL. BASEL: MDPI, 2026, roč. 13, č. 1, s. 1-12. ISSN 2227-9067. Dostupné z: https://doi.org/10.3390/children13010105.

@article{2560978,
   author = {Szturzová, Kateřina and Zelinková, Hana and Knoppová, Lenka and Ťoukálková, Michaela and Kramplová, Tereza and Kovář, Marek and Klučka, Jozef and Štourač, Petr},
   article_location = {BASEL},
   article_number = {1},
   doi = {https://doi.org/10.3390/children13010105},
   keywords = {general anaesthesia; surgery; non-depolarizing neuromuscular blockers; rocuronium; sugammadex; train of four},
   language = {eng},
   issn = {2227-9067},
   journal = {CHILDREN-BASEL},
   title = {Interindividual Variability in Duration of Action of Rocuronium in Paediatric Patients (DurAct): A Prospective Observational Study},
   url = {https://www.mdpi.com/2227-9067/13/1/105},
   volume = {13},
   year = {2026}
}

TY  - JOUR
ID  - 2560978
AU  - Szturzová, Kateřina - Zelinková, Hana - Knoppová, Lenka - Ťoukálková, Michaela - Kramplová, Tereza - Kovář, Marek - Klučka, Jozef - Štourač, Petr
PY  - 2026
TI  - Interindividual Variability in Duration of Action of Rocuronium in Paediatric Patients (DurAct): A Prospective Observational Study
JF  - CHILDREN-BASEL
VL  - 13
IS  - 1
SP  - 1-12
EP  - 1-12
PB  - MDPI
SN  - 22279067
KW  - general anaesthesia
KW  - surgery
KW  - non-depolarizing neuromuscular blockers
KW  - rocuronium
KW  - sugammadex
KW  - train of four
UR  - https://www.mdpi.com/2227-9067/13/1/105
N2  - Highlights What are the main findings? Time to return of TOF 1 did not differ significantly across paediatric age groups. No association between TOF recovery time and sex, weight, height, or body temperature was found. What are the implications of the main findings? The observed high interindividual variability in rocuronium duration, unrelated to patient factors, calls for individualized dosing and strict neuromuscular monitoring in paediatric patients.Highlights What are the main findings? Time to return of TOF 1 did not differ significantly across paediatric age groups. No association between TOF recovery time and sex, weight, height, or body temperature was found. What are the implications of the main findings? The observed high interindividual variability in rocuronium duration, unrelated to patient factors, calls for individualized dosing and strict neuromuscular monitoring in paediatric patients.Abstract Background: In adult patients, rocuronium shows interindividual variability related to weight, sex, and age, but paediatric data are limited. This study aimed to evaluate clinical factors influencing the duration of action of rocuronium in children. Methods: Patients aged between 0 and 18 years undergoing planned general anaesthesia were eligible. The primary objective was to compare the duration of clinical action of rocuronium after a single dose, measured until the return of TOF (Train of Four) 1, across three-group age categories. Secondary objectives explored the relationship between TOF recovery and sex, weight, height, initial body temperature, as well as the occurrence of postoperative complications related to general anaesthesia. Results: Among 96 analysed patients, no clinically relevant association was found between the duration of rocuronium action and the studied clinical factors. TOF 1 occurred at 18.1 +/- 9.5 min in those aged 1 to 5 years (n = 26), 16.8 +/- 14.5 min in those aged 6 to 10 years (n = 33), and 18.2 +/- 13.8 min in those aged 10 to 17 years (n = 37), p = 0.626. A post hoc analysis revealed high variability in recovery times across TOF levels, both in the per-protocol population (e.g., TOF 1: 17.7 +/- 12.9 min) and in patients who did not receive sugammadex. Conclusions: In paediatric patients, the duration of rocuronium action after a single dose demonstrated substantial interindividual variability, which was not explained by age, sex, weight, height, or body temperature.
ER  -

SZTURZOVÁ, Kateřina; Hana ZELINKOVÁ; Lenka KNOPPOVÁ; Michaela ŤOUKÁLKOVÁ; Tereza KRAMPLOVÁ; Marek KOVÁŘ; Jozef KLUČKA a Petr ŠTOURAČ. Interindividual Variability in Duration of Action of Rocuronium in Paediatric Patients (DurAct): A Prospective Observational Study. \textit{CHILDREN-BASEL}. BASEL: MDPI, 2026, roč.~13, č.~1, s.~1-12. ISSN~2227-9067. Dostupné z: https://doi.org/10.3390/children13010105.

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