Shaping death: how the microbiome regulates tumour cell demise
and therapy response

J 2026

Shaping death: how the microbiome regulates tumour cell demise and therapy response

RAUDENSKÁ, Martina; Jan BALVAN; Eliška ZGARBOVÁ; David KALFERT; Jan PLZAK et al.

Základní údaje

Originální název

Shaping death: how the microbiome regulates tumour cell demise and therapy response

Autoři

RAUDENSKÁ, Martina ; Jan BALVAN; Eliška ZGARBOVÁ ; David KALFERT; Jan PLZAK a Michal MASAŘÍK

Vydání

CANCER AND METASTASIS REVIEWS, DORDRECHT, SPRINGER, 2026, 0167-7659

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 8.700 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Cell death; Apoptosis; Ferroptosis; Microbial metabolites; Cancer metabolism; Cancer therapy; Microbiome

Štítky

14110515, 14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 4. 2026 12:44, Mgr. Tereza Miškechová

Anotace

V originále

Cell death is a fundamental process that maintains tissue homeostasis and shapes the tumour microenvironment. Cancer cells often evade or reprogram cell death pathways, which leads to malignancy and therapy resistance. On the other hand, the cell death of non-malignant cells significantly influences the adverse effects of anticancer therapy, such as the onset of mucositis or enteritis. Emerging evidence identifies both the tumour and gut microbiomes as critical modulators of these processes. In turn, cell death reshapes the microbial ecosystem by altering nutrient landscapes and immune signalling. Although both cell death and the microbiome are well-studied in cancer, their intersection remains underexplored. This review article addresses this gap by summarising how microbes and microbial metabolites modulate cancer cell death pathways and shape responses to anticancer therapy. We integrated current knowledge on this complex interplay, focusing on key metabolic mediators that can influence cell fate decisions. Understanding this bidirectional crosstalk offers new opportunities to "preserve the good and eliminate the bad" within the tumour-microbiome axis, paving the way for precision microbiome-informed cancer therapies.

Návaznosti

MUNI/A/1790/2024, interní kód MU

Název: Patofyziologie běžných komplexních nemocí: od molekuly k organizmu

Investor: Masarykova univerzita, Patofyziologie běžných komplexních nemocí: od molekuly k organizmu

NU23-03-00274, projekt VaV

Název: Složení ústního a střevního mikrobiomu jako prediktor odpovědi na léčbu u pacientů s karcinomem hlavy a krku

Investor: Ministerstvo zdravotnictví ČR, Složení ústního a střevního mikrobiomu jako prediktor odpovědi na léčbu u pacientů s karcinomem hlavy a krku

Citovat

RAUDENSKÁ, Martina; Jan BALVAN; Eliška ZGARBOVÁ; David KALFERT; Jan PLZAK a Michal MASAŘÍK. Shaping death: how the microbiome regulates tumour cell demise and therapy response. CANCER AND METASTASIS REVIEWS. DORDRECHT: SPRINGER, 2026, roč. 45, č. 1, s. 1-28. ISSN 0167-7659. Dostupné z: https://doi.org/10.1007/s10555-026-10318-1.

@article{2565345,
   author = {Raudenská, Martina and Balvan, Jan and Zgarbová, Eliška and Kalfert, David and Plzak, Jan and Masařík, Michal},
   article_location = {DORDRECHT},
   article_number = {1},
   doi = {https://doi.org/10.1007/s10555-026-10318-1},
   keywords = {Cell death; Apoptosis; Ferroptosis; Microbial metabolites; Cancer metabolism; Cancer therapy; Microbiome},
   language = {eng},
   issn = {0167-7659},
   journal = {CANCER AND METASTASIS REVIEWS},
   title = {Shaping death: how the microbiome regulates tumour cell demise and therapy response},
   url = {https://link.springer.com/article/10.1007/s10555-026-10318-1},
   volume = {45},
   year = {2026}
}

TY  - JOUR
ID  - 2565345
AU  - Raudenská, Martina - Balvan, Jan - Zgarbová, Eliška - Kalfert, David - Plzak, Jan - Masařík, Michal
PY  - 2026
TI  - Shaping death: how the microbiome regulates tumour cell demise and therapy response
JF  - CANCER AND METASTASIS REVIEWS
VL  - 45
IS  - 1
SP  - 1-28
EP  - 1-28
PB  - SPRINGER
SN  - 01677659
KW  - Cell death
KW  - Apoptosis
KW  - Ferroptosis
KW  - Microbial metabolites
KW  - Cancer metabolism
KW  - Cancer therapy
KW  - Microbiome
UR  - https://link.springer.com/article/10.1007/s10555-026-10318-1
N2  - Cell death is a fundamental process that maintains tissue homeostasis and shapes the tumour microenvironment. Cancer cells often evade or reprogram cell death pathways, which leads to malignancy and therapy resistance. On the other hand, the cell death of non-malignant cells significantly influences the adverse effects of anticancer therapy, such as the onset of mucositis or enteritis. Emerging evidence identifies both the tumour and gut microbiomes as critical modulators of these processes. In turn, cell death reshapes the microbial ecosystem by altering nutrient landscapes and immune signalling. Although both cell death and the microbiome are well-studied in cancer, their intersection remains underexplored. This review article addresses this gap by summarising how microbes and microbial metabolites modulate cancer cell death pathways and shape responses to anticancer therapy. We integrated current knowledge on this complex interplay, focusing on key metabolic mediators that can influence cell fate decisions. Understanding this bidirectional crosstalk offers new opportunities to "preserve the good and eliminate the bad" within the tumour-microbiome axis, paving the way for precision microbiome-informed cancer therapies.
ER  -

RAUDENSKÁ, Martina; Jan BALVAN; Eliška ZGARBOVÁ; David KALFERT; Jan PLZAK a Michal MASAŘÍK. Shaping death: how the microbiome regulates tumour cell demise and therapy response. \textit{CANCER AND METASTASIS REVIEWS}. DORDRECHT: SPRINGER, 2026, roč.~45, č.~1, s.~1-28. ISSN~0167-7659. Dostupné z: https://doi.org/10.1007/s10555-026-10318-1.

Přehled o publikaci