Enamel decussation pattern originates from directional sliding
of ameloblasts

J 2026

Enamel decussation pattern originates from directional sliding of ameloblasts

RAKULTSEV, Vladislav; Josef LAVICKÝ; Marcos GONZÁLEZ LÓPEZ; Klára CIGOŠOVÁ; Igor ADAMEYKO et al.

Základní údaje

Originální název

Enamel decussation pattern originates from directional sliding of ameloblasts

Autoři

RAKULTSEV, Vladislav; Josef LAVICKÝ; Marcos GONZÁLEZ LÓPEZ; Klára CIGOŠOVÁ ; Igor ADAMEYKO a Jan KŘIVÁNEK

Vydání

International Journal of Oral Science, LONDON, SPRINGERNATURE, 2026, 1674-2818

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30208 Dentistry, oral surgery and medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 12.200 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

enamel decussation; ameloblasts; enamel formation; tooth development; biomineralization

Štítky

14110517, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 4. 2026 14:50, Mgr. Tereza Miškechová

Anotace

V originále

Enamel, the inorganic tissue covering the crowns of teeth, is known for its remarkable resilience and hardness. These properties originate from its high proportion of mineralized matrix and complex internal microarchitecture. On an ultrastructural level, it consists of directionally arranged enamel prisms. Continuously growing rodent incisors are an exemplary case of this phenomenon. Their enamel has a consistent decussation pattern, providing teeth with extremely high resistance and ensuring they remain constantly sharp. While the decussation pattern has been described in detail, mechanisms behind its formation have not been experimentally proven. Here, we show that the highly organized enamel micropattern is generated by directional epithelial sliding of enamel-forming ameloblasts in vivo. Our results detail how enamel micropatterning stems from individual cell cluster segregation and subsequent reciprocal interweaving. Based on this determination, we introduce and experimentally demonstrate a new model of enamel decussation pattern formation.

Návaznosti

GA23-06160S, projekt VaV

Název: Fluktuace mikroprostředí kmenových buněk jako zdroj tkáňové adaptability ve zdraví a nemoci

Investor: Grantová agentura ČR, Fluktuace mikroprostředí kmenových buněk jako zdroj tkáňové adaptability ve zdraví a nemoci

LM2023050, projekt VaV

Název: Národní infrastruktura pro biologické a medicínské zobrazování

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Czech BioImaging: Národní výzkumná infrastruktura pro biologické a medicínské zobrazování

MUNI/A/1738/2024, interní kód MU

Název: Zdroje pro tkáňové inženýrství 15

Investor: Masarykova univerzita, Zdroje pro tkáňové inženýrství 15

Citovat

RAKULTSEV, Vladislav; Josef LAVICKÝ; Marcos GONZÁLEZ LÓPEZ; Klára CIGOŠOVÁ; Igor ADAMEYKO a Jan KŘIVÁNEK. Enamel decussation pattern originates from directional sliding of ameloblasts. International Journal of Oral Science. LONDON: SPRINGERNATURE, 2026, roč. 18, č. 1, s. 1-12. ISSN 1674-2818. Dostupné z: https://doi.org/10.1038/s41368-025-00412-5.

@article{2565370,
   author = {Rakultsev, Vladislav and Lavický, Josef and González López, Marcos and Cigošová, Klára and Adameyko, Igor and Křivánek, Jan},
   article_location = {LONDON},
   article_number = {1},
   doi = {https://doi.org/10.1038/s41368-025-00412-5},
   keywords = {enamel decussation; ameloblasts; enamel formation; tooth development; biomineralization},
   language = {eng},
   issn = {1674-2818},
   journal = {International Journal of Oral Science},
   title = {Enamel decussation pattern originates from directional sliding of ameloblasts},
   url = {https://www.nature.com/articles/s41368-025-00412-5},
   volume = {18},
   year = {2026}
}

TY  - JOUR
ID  - 2565370
AU  - Rakultsev, Vladislav - Lavický, Josef - González López, Marcos - Cigošová, Klára - Adameyko, Igor - Křivánek, Jan
PY  - 2026
TI  - Enamel decussation pattern originates from directional sliding of ameloblasts
JF  - International Journal of Oral Science
VL  - 18
IS  - 1
SP  - 1-12
EP  - 1-12
PB  - SPRINGERNATURE
SN  - 16742818
KW  - enamel decussation
KW  - ameloblasts
KW  - enamel formation
KW  - tooth development
KW  - biomineralization
UR  - https://www.nature.com/articles/s41368-025-00412-5
N2  - Enamel, the inorganic tissue covering the crowns of teeth, is known for its remarkable resilience and hardness. These properties originate from its high proportion of mineralized matrix and complex internal microarchitecture. On an ultrastructural level, it consists of directionally arranged enamel prisms. Continuously growing rodent incisors are an exemplary case of this phenomenon. Their enamel has a consistent decussation pattern, providing teeth with extremely high resistance and ensuring they remain constantly sharp. While the decussation pattern has been described in detail, mechanisms behind its formation have not been experimentally proven. Here, we show that the highly organized enamel micropattern is generated by directional epithelial sliding of enamel-forming ameloblasts in vivo. Our results detail how enamel micropatterning stems from individual cell cluster segregation and subsequent reciprocal interweaving. Based on this determination, we introduce and experimentally demonstrate a new model of enamel decussation pattern formation.
ER  -

RAKULTSEV, Vladislav; Josef LAVICKÝ; Marcos GONZÁLEZ LÓPEZ; Klára CIGOŠOVÁ; Igor ADAMEYKO a Jan KŘIVÁNEK. Enamel decussation pattern originates from directional sliding of ameloblasts. \textit{International Journal of Oral Science}. LONDON: SPRINGERNATURE, 2026, roč.~18, č.~1, s.~1-12. ISSN~1674-2818. Dostupné z: https://doi.org/10.1038/s41368-025-00412-5.

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