MCI-LB brain networks reorganization in relation to specific
cognitive domains deficits

J 2026

MCI-LB brain networks reorganization in relation to specific cognitive domains deficits

ONOFRJ, Valeria; Raffaella FRANCIOTTI; Kristína MITTEROVÁ; Luboš BRABENEC; Martin GAJDOŠ et al.

Základní údaje

Originální název

MCI-LB brain networks reorganization in relation to specific cognitive domains deficits

Autoři

Vydání

Scientific Reports, Berlin, NATURE RESEARCH, 2026, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.900 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Functional magnetic resonance imaging (fMRI); Mild cognitive impairment with lewy bodies (MCI-LB); Resting state functional connectivity; Large-scale brain networks

Štítky

14110127

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 4. 2026 10:32, Mgr. Tereza Miškechová

Anotace

V originále

To tackle the disease-related process in early pre-dementia Lewy Body Dementia, we investigated the changes of functional brain networks and their cognitive relevance. A cohort of 38 Mild Cognitive Impairment with Lewy Bodies (MCI-LB) subjects and one of 24 healthy controls (HC) underwent neuropsychological assessment and resting state (RS) functional and structural MRI. Functional connectivity (FC) between ROIs belonging to a set of RS networks, including the Salience Network (SN), Fronto-Parietal (FPN), Default Mode (DMN), Dorsal and Ventral Attention (DAN and VAN), Somato-Motor (SMN), Visual (VN) and Language (LN) was estimated and compared between cohorts. Finally, neuropsychological scores were correlated with FC of MCI-LB and HC separately. Compared to HC, MCI-LB exhibited lower FC between DAN, FPN and LN. Higher inter-network FC was found between FPN and SN, FPN and DMN, SN and SMN and DAN and SMN. In MCI-LB the correlational analysis revealed significant positive and negative associations between cognitive performance and FC values between nodes. In conclusion, we found a possible compensation mechanism between nodes in SN and FPN, and FPN and DMN following disconnection between the control system of the FPN and the top down attention system. The complex compensatory mechanisms involving multiple networks may not be efficient to counteract the cognitive impairment in MCI-LB. Overall, in MCI-LB we found an aberrant engagement of the networks that are not primarily involved in the performance of specific tasks.

Návaznosti

LM2023050, projekt VaV

Název: Národní infrastruktura pro biologické a medicínské zobrazování

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Czech BioImaging: Národní výzkumná infrastruktura pro biologické a medicínské zobrazování

LX22NPO5107, projekt VaV

Název: Národní ústav pro neurologický výzkum

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní ústav pro neurologický výzkum, 5.1 EXCELES

NU21J-04-00077, projekt VaV

Název: Využití dynamických parametrů funkční konektivity mozku jako diagnostického biomarkeru neurodegenerativních nemocí

Investor: Ministerstvo zdravotnictví ČR, Využití dynamických parametrů funkční konektivity mozku jako diagnostického biomarkeru neurodegenerativních nemocí, Podprogram 2 - juniorský - výzkumníci do 35 let

Citovat

ONOFRJ, Valeria; Raffaella FRANCIOTTI; Kristína MITTEROVÁ; Luboš BRABENEC; Martin GAJDOŠ; Ivona MORÁVKOVÁ; Antonio FERRETTI; Sara SPADONE; Caterina PADULO; Antonello BALDASSARRE; Stefano L SENSI a Irena REKTOROVÁ. MCI-LB brain networks reorganization in relation to specific cognitive domains deficits. Scientific Reports. Berlin: NATURE RESEARCH, 2026, roč. 16, č. 1, s. 1-13. ISSN 2045-2322. Dostupné z: https://doi.org/10.1038/s41598-026-36953-w.

@article{2565440,
   author = {Onofrj, Valeria and Franciotti, Raffaella and Mitterová, Kristína and Brabenec, Luboš and Gajdoš, Martin and Morávková, Ivona and Ferretti, Antonio and Spadone, Sara and Padulo, Caterina and Baldassarre, Antonello and Sensi, Stefano L and Rektorová, Irena},
   article_location = {Berlin},
   article_number = {1},
   doi = {https://doi.org/10.1038/s41598-026-36953-w},
   keywords = {Functional magnetic resonance imaging (fMRI); Mild cognitive impairment with lewy bodies (MCI-LB); Resting state functional connectivity; Large-scale brain networks},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {MCI-LB brain networks reorganization in relation to specific cognitive domains deficits},
   url = {https://www.nature.com/articles/s41598-026-36953-w},
   volume = {16},
   year = {2026}
}

TY  - JOUR
ID  - 2565440
AU  - Onofrj, Valeria - Franciotti, Raffaella - Mitterová, Kristína - Brabenec, Luboš - Gajdoš, Martin - Morávková, Ivona - Ferretti, Antonio - Spadone, Sara - Padulo, Caterina - Baldassarre, Antonello - Sensi, Stefano L - Rektorová, Irena
PY  - 2026
TI  - MCI-LB brain networks reorganization in relation to specific cognitive domains deficits
JF  - Scientific Reports
VL  - 16
IS  - 1
SP  - 1-13
EP  - 1-13
PB  - NATURE RESEARCH
SN  - 20452322
KW  - Functional magnetic resonance imaging (fMRI)
KW  - Mild cognitive impairment with lewy bodies (MCI-LB)
KW  - Resting state functional connectivity
KW  - Large-scale brain networks
UR  - https://www.nature.com/articles/s41598-026-36953-w
N2  - To tackle the disease-related process in early pre-dementia Lewy Body Dementia, we investigated the changes of functional brain networks and their cognitive relevance. A cohort of 38 Mild Cognitive Impairment with Lewy Bodies (MCI-LB) subjects and one of 24 healthy controls (HC) underwent neuropsychological assessment and resting state (RS) functional and structural MRI. Functional connectivity (FC) between ROIs belonging to a set of RS networks, including the Salience Network (SN), Fronto-Parietal (FPN), Default Mode (DMN), Dorsal and Ventral Attention (DAN and VAN), Somato-Motor (SMN), Visual (VN) and Language (LN) was estimated and compared between cohorts. Finally, neuropsychological scores were correlated with FC of MCI-LB and HC separately. Compared to HC, MCI-LB exhibited lower FC between DAN, FPN and LN. Higher inter-network FC was found between FPN and SN, FPN and DMN, SN and SMN and DAN and SMN. In MCI-LB the correlational analysis revealed significant positive and negative associations between cognitive performance and FC values between nodes. In conclusion, we found a possible compensation mechanism between nodes in SN and FPN, and FPN and DMN following disconnection between the control system of the FPN and the top down attention system. The complex compensatory mechanisms involving multiple networks may not be efficient to counteract the cognitive impairment in MCI-LB. Overall, in MCI-LB we found an aberrant engagement of the networks that are not primarily involved in the performance of specific tasks.
ER  -

ONOFRJ, Valeria; Raffaella FRANCIOTTI; Kristína MITTEROVÁ; Luboš BRABENEC; Martin GAJDOŠ; Ivona MORÁVKOVÁ; Antonio FERRETTI; Sara SPADONE; Caterina PADULO; Antonello BALDASSARRE; Stefano L SENSI a Irena REKTOROVÁ. MCI-LB brain networks reorganization in relation to specific cognitive domains deficits. \textit{Scientific Reports}. Berlin: NATURE RESEARCH, 2026, roč.~16, č.~1, s.~1-13. ISSN~2045-2322. Dostupné z: https://doi.org/10.1038/s41598-026-36953-w.

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