Lower Gyrification of the Ventromedial Prefrontal Cortex in Posttraumatic Stress Disorder: An ENIGMA-PTSD Study
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HUSSAIN, Ahmed; C Lexi BAIRD; Ashley A HUGGINS; Courtney C RUSSELL; Delin SUN; Leonel RANGEL-JIMENEZ; Chadi G ABDALLAH; Michael ANGSTADT; Geoffrey MAY; Hannah BERG; Jennifer U BLACKFORD; Josh CISLER; Judith K DANIELS; Nicholas D DAVENPORT; Richard J DAVIDSON; Maria DENSMORE; Seth G DISNER; Wissam EL-HAGE; Amit ETKIN; Negar FANI; Jessie L FRIJLING; Evan M GORDON; Daniel W GRUPE; Ryan A HERRINGA; Julia I HERZOG; David HOFMANN; Anna R HUDSON; Tanja JOVANOVIC; Anthony KING; Saskia B J KOCH; Ruth A LANIUS; Amit LAZAROV; Gen LI; Israel LIBERZON; Shmuel LISSEK; Guangming LU; Antje MANTHEY; Adi MARON-KATZ; Katie A MCLAUGHLIN; Sven C MUELLER; Laura NAWIJN; Steven M NELSON; Yuval NERIA; Richard W J NEUFELD; Jack B NITSCHKE; Bunmi O OLATUNJI; Miranda OLFF; Matthew PEVERILL; Rongfeng QI; Yann QUIDE; Orren RAVID; Ivan REKTOR; Kerry J RESSLER; Pavel ŘÍHA; Marisa ROSS; Kelly SAMBROOK; Christian SCHMAHL; Anika SIERK; Scott R SPONHEIM; Jennifer S STEVENS; Thomas STRAUBE; Benjamin SUAREZ-JIMENEZ; Jean THEBERGE; J A VAN DER WEE NIC; J A VAN DER WERFF STEVEN; J H VAN ROOIJ SANNE; van Zuiden MIRJAM; Dick J VELTMAN; Robert R J M VERMEIREN; Henrik WALTER; Li WANG; Xi ZHU; Ye ZHU; Sigal ZILCHA-MANO; Neda JAHANSHAD; Paul M THOMPSON a Rajendra A MOREY
Vydání
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE, AMSTERDAM, ELSEVIER, 2026, 2667-1743
BACKGROUND: Cortical gyrification involves the formation of folds in the cerebral cortex, coinciding with key neurodevelopmental processes. Its strong correlation with increased cortical surface area and decreased cortical thickness may improve cortical signaling efficiency by decreasing cortico-cortical distance. Differences in brain structure have been found in posttraumatic stress disorder (PTSD), yet few small studies have examined cortical gyrification. METHODS: Gyrification was quantified using FreeSurfer's Local Gyrification Index (lGI), derived from 3-dimensional T1-weighted volumetric brain magnetic resonance imaging in 1876 participants (PTSD n = 789, control n = 1087) across 24 sites from the ENIGMA-PGC (Enhancing Neuro Imaging Genetics through Meta-Analysis and Psychiatric Genomics Consortium) PTSD working group. Using a region of interest-based approach, we fitted a linear mixed-effects model with age (mean = 35.6, SD = 9.23, range = 8-95), sex (female = 967 [52%], male = 909 [48%]), pial surface area, PTSD, and random site effects to test associations between PTSD diagnosis/ severity and regional lGI. We examined moderating effects of depression, childhood trauma, age, and sex. RESULTS: PTSD diagnosis and severity were both associated with lower lGI for the right medial orbitofrontal and right rostral anterior cingulate cortices. The interaction of PTSD and age was associated with lower lGI for the rostral middle frontal cortex bilaterally. Contrasting comorbid PTSD and major depressive disorder with the PTSD-only group showed that comorbidity was associated with lower lGI in the left inferior and medial temporal cortices. CONCLUSIONS: Lower lGI, which is associated with impaired signaling efficiency, was observed in the PTSD group compared with the control group for the ventromedial prefrontal cortex, a region that has been strongly implicated in associative fear learning and extinction. It is possible that PTSD accelerates the typical age-associated decline in lGI of the rostral middle frontal cortices.
Návaznosti
NV18-04-00559, projekt VaV
Název: Neurobiologické a psychologické markery reakce na extrémní stres a jeho dopad na potomky - třígenerační studie přeživších holokaust a jejich potomků
Investor: Ministerstvo zdravotnictví ČR, Neurobiologické a psychologické markery reakce na extrémní stres a dopad na generace potomků - třígenerační studie přeživších holokaust a jejich potomků
HUSSAIN, Ahmed; C Lexi BAIRD; Ashley A HUGGINS; Courtney C RUSSELL; Delin SUN; Leonel RANGEL-JIMENEZ; Chadi G ABDALLAH; Michael ANGSTADT; Geoffrey MAY; Hannah BERG; Jennifer U BLACKFORD; Josh CISLER; Judith K DANIELS; Nicholas D DAVENPORT; Richard J DAVIDSON; Maria DENSMORE; Seth G DISNER; Wissam EL-HAGE; Amit ETKIN; Negar FANI; Jessie L FRIJLING; Evan M GORDON; Daniel W GRUPE; Ryan A HERRINGA; Julia I HERZOG; David HOFMANN; Anna R HUDSON; Tanja JOVANOVIC; Anthony KING; Saskia B J KOCH; Ruth A LANIUS; Amit LAZAROV; Gen LI; Israel LIBERZON; Shmuel LISSEK; Guangming LU; Antje MANTHEY; Adi MARON-KATZ; Katie A MCLAUGHLIN; Sven C MUELLER; Laura NAWIJN; Steven M NELSON; Yuval NERIA; Richard W J NEUFELD; Jack B NITSCHKE; Bunmi O OLATUNJI; Miranda OLFF; Matthew PEVERILL; Rongfeng QI; Yann QUIDE; Orren RAVID; Ivan REKTOR; Kerry J RESSLER; Pavel ŘÍHA; Marisa ROSS; Kelly SAMBROOK; Christian SCHMAHL; Anika SIERK; Scott R SPONHEIM; Jennifer S STEVENS; Thomas STRAUBE; Benjamin SUAREZ-JIMENEZ; Jean THEBERGE; J A VAN DER WEE NIC; J A VAN DER WERFF STEVEN; J H VAN ROOIJ SANNE; van Zuiden MIRJAM; Dick J VELTMAN; Robert R J M VERMEIREN; Henrik WALTER; Li WANG; Xi ZHU; Ye ZHU; Sigal ZILCHA-MANO; Neda JAHANSHAD; Paul M THOMPSON a Rajendra A MOREY. Lower Gyrification of the Ventromedial Prefrontal Cortex in Posttraumatic Stress Disorder: An ENIGMA-PTSD Study. BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE. AMSTERDAM: ELSEVIER, 2026, roč. 6, č. 2, s. 1-12. ISSN 2667-1743. Dostupné z: https://doi.org/10.1016/j.bpsgos.2025.100679.
@article{2565597, author = {Hussain, Ahmed and Baird, C Lexi and Huggins, Ashley A and Russell, Courtney C and Sun, Delin and RangelandJimenez, Leonel and Abdallah, Chadi G and Angstadt, Michael and May, Geoffrey and Berg, Hannah and Blackford, Jennifer U and Cisler, Josh and Daniels, Judith K and Davenport, Nicholas D and Davidson, Richard J and Densmore, Maria and Disner, Seth G and ElandHage, Wissam and Etkin, Amit and Fani, Negar and Frijling, Jessie L and Gordon, Evan M and Grupe, Daniel W and Herringa, Ryan A and Herzog, Julia I and Hofmann, David and Hudson, Anna R and Jovanovic, Tanja and King, Anthony and Koch, Saskia B J and Lanius, Ruth A and Lazarov, Amit and Li, Gen and Liberzon, Israel and Lissek, Shmuel and Lu, Guangming and Manthey, Antje and MaronandKatz, Adi and McLaughlin, Katie A and Mueller, Sven C and Nawijn, Laura and Nelson, Steven M and Neria, Yuval and Neufeld, Richard W J and Nitschke, Jack B and Olatunji, Bunmi O and Olff, Miranda and Peverill, Matthew and Qi, Rongfeng and Quide, Yann and Ravid, Orren and Rektor, Ivan and Ressler, Kerry J and Říha, Pavel and Ross, Marisa and Sambrook, Kelly and Schmahl, Christian and Sierk, Anika and Sponheim, Scott R and Stevens, Jennifer S and Straube, Thomas and SuarezandJimenez, Benjamin and Theberge, Jean and van der Wee Nic, J A and van der Werff Steven, J A and van Rooij Sanne, J H and Mirjam, van Zuiden and Veltman, Dick J and Vermeiren, Robert R J M and Walter, Henrik and Wang, Li and Zhu, Xi and Zhu, Ye and ZilchaandMano, Sigal and Jahanshad, Neda and Thompson, Paul M and Morey, Rajendra A}, article_location = {AMSTERDAM}, article_number = {2}, doi = {https://doi.org/10.1016/j.bpsgos.2025.100679}, keywords = {ventromedial prefrontal cortex; cortical gyrification; posttraumatic stress disorder; ENIGMA-PTSD; neuroimaging}, language = {eng}, issn = {2667-1743}, journal = {BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE}, title = {Lower Gyrification of the Ventromedial Prefrontal Cortex in Posttraumatic Stress Disorder: An ENIGMA-PTSD Study}, url = {https://www.sciencedirect.com/science/article/pii/S2667174325002332?via%3Dihub}, volume = {6}, year = {2026} }
TY - JOUR ID - 2565597 AU - Hussain, Ahmed - Baird, C Lexi - Huggins, Ashley A - Russell, Courtney C - Sun, Delin - Rangel-Jimenez, Leonel - Abdallah, Chadi G - Angstadt, Michael - May, Geoffrey - Berg, Hannah - Blackford, Jennifer U - Cisler, Josh - Daniels, Judith K - Davenport, Nicholas D - Davidson, Richard J - Densmore, Maria - Disner, Seth G - El-Hage, Wissam - Etkin, Amit - Fani, Negar - Frijling, Jessie L - Gordon, Evan M - Grupe, Daniel W - Herringa, Ryan A - Herzog, Julia I - Hofmann, David - Hudson, Anna R - Jovanovic, Tanja - King, Anthony - Koch, Saskia B J - Lanius, Ruth A - Lazarov, Amit - Li, Gen - Liberzon, Israel - Lissek, Shmuel - Lu, Guangming - Manthey, Antje - Maron-Katz, Adi - McLaughlin, Katie A - Mueller, Sven C - Nawijn, Laura - Nelson, Steven M - Neria, Yuval - Neufeld, Richard W J - Nitschke, Jack B - Olatunji, Bunmi O - Olff, Miranda - Peverill, Matthew - Qi, Rongfeng - Quide, Yann - Ravid, Orren - Rektor, Ivan - Ressler, Kerry J - Říha, Pavel - Ross, Marisa - Sambrook, Kelly - Schmahl, Christian - Sierk, Anika - Sponheim, Scott R - Stevens, Jennifer S - Straube, Thomas - Suarez-Jimenez, Benjamin - Theberge, Jean - van der Wee Nic, J A - van der Werff Steven, J A - van Rooij Sanne, J H - Mirjam, van Zuiden - Veltman, Dick J - Vermeiren, Robert R J M - Walter, Henrik - Wang, Li - Zhu, Xi - Zhu, Ye - Zilcha-Mano, Sigal - Jahanshad, Neda - Thompson, Paul M - Morey, Rajendra A PY - 2026 TI - Lower Gyrification of the Ventromedial Prefrontal Cortex in Posttraumatic Stress Disorder: An ENIGMA-PTSD Study JF - BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE VL - 6 IS - 2 SP - 1-12 EP - 1-12 PB - ELSEVIER SN - 26671743 KW - ventromedial prefrontal cortex KW - cortical gyrification KW - posttraumatic stress disorder KW - ENIGMA-PTSD KW - neuroimaging UR - https://www.sciencedirect.com/science/article/pii/S2667174325002332?via%3Dihub N2 - BACKGROUND: Cortical gyrification involves the formation of folds in the cerebral cortex, coinciding with key neurodevelopmental processes. Its strong correlation with increased cortical surface area and decreased cortical thickness may improve cortical signaling efficiency by decreasing cortico-cortical distance. Differences in brain structure have been found in posttraumatic stress disorder (PTSD), yet few small studies have examined cortical gyrification. METHODS: Gyrification was quantified using FreeSurfer's Local Gyrification Index (lGI), derived from 3-dimensional T1-weighted volumetric brain magnetic resonance imaging in 1876 participants (PTSD n = 789, control n = 1087) across 24 sites from the ENIGMA-PGC (Enhancing Neuro Imaging Genetics through Meta-Analysis and Psychiatric Genomics Consortium) PTSD working group. Using a region of interest-based approach, we fitted a linear mixed-effects model with age (mean = 35.6, SD = 9.23, range = 8-95), sex (female = 967 [52%], male = 909 [48%]), pial surface area, PTSD, and random site effects to test associations between PTSD diagnosis/ severity and regional lGI. We examined moderating effects of depression, childhood trauma, age, and sex. RESULTS: PTSD diagnosis and severity were both associated with lower lGI for the right medial orbitofrontal and right rostral anterior cingulate cortices. The interaction of PTSD and age was associated with lower lGI for the rostral middle frontal cortex bilaterally. Contrasting comorbid PTSD and major depressive disorder with the PTSD-only group showed that comorbidity was associated with lower lGI in the left inferior and medial temporal cortices. CONCLUSIONS: Lower lGI, which is associated with impaired signaling efficiency, was observed in the PTSD group compared with the control group for the ventromedial prefrontal cortex, a region that has been strongly implicated in associative fear learning and extinction. It is possible that PTSD accelerates the typical age-associated decline in lGI of the rostral middle frontal cortices. ER -
HUSSAIN, Ahmed; C Lexi BAIRD; Ashley A HUGGINS; Courtney C RUSSELL; Delin SUN; Leonel RANGEL-JIMENEZ; Chadi G ABDALLAH; Michael ANGSTADT; Geoffrey MAY; Hannah BERG; Jennifer U BLACKFORD; Josh CISLER; Judith K DANIELS; Nicholas D DAVENPORT; Richard J DAVIDSON; Maria DENSMORE; Seth G DISNER; Wissam EL-HAGE; Amit ETKIN; Negar FANI; Jessie L FRIJLING; Evan M GORDON; Daniel W GRUPE; Ryan A HERRINGA; Julia I HERZOG; David HOFMANN; Anna R HUDSON; Tanja JOVANOVIC; Anthony KING; Saskia B J KOCH; Ruth A LANIUS; Amit LAZAROV; Gen LI; Israel LIBERZON; Shmuel LISSEK; Guangming LU; Antje MANTHEY; Adi MARON-KATZ; Katie A MCLAUGHLIN; Sven C MUELLER; Laura NAWIJN; Steven M NELSON; Yuval NERIA; Richard W J NEUFELD; Jack B NITSCHKE; Bunmi O OLATUNJI; Miranda OLFF; Matthew PEVERILL; Rongfeng QI; Yann QUIDE; Orren RAVID; Ivan REKTOR; Kerry J RESSLER; Pavel ŘÍHA; Marisa ROSS; Kelly SAMBROOK; Christian SCHMAHL; Anika SIERK; Scott R SPONHEIM; Jennifer S STEVENS; Thomas STRAUBE; Benjamin SUAREZ-JIMENEZ; Jean THEBERGE; J A VAN DER WEE NIC; J A VAN DER WERFF STEVEN; J H VAN ROOIJ SANNE; van Zuiden MIRJAM; Dick J VELTMAN; Robert R J M VERMEIREN; Henrik WALTER; Li WANG; Xi ZHU; Ye ZHU; Sigal ZILCHA-MANO; Neda JAHANSHAD; Paul M THOMPSON a Rajendra A MOREY. Lower Gyrification of the Ventromedial Prefrontal Cortex in Posttraumatic Stress Disorder: An ENIGMA-PTSD Study. \textit{BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE}. AMSTERDAM: ELSEVIER, 2026, roč.~6, č.~2, s.~1-12. ISSN~2667-1743. Dostupné z: https://doi.org/10.1016/j.bpsgos.2025.100679.