J 2026

ClotPro® haemostasis in pregnancy: physiological parameters, reference intervals and comparison with non-pregnant women in a prospective observational study

VRBICA, Kamil; Jan ŠTINGL; Kateřina VANÍČKOVÁ; Ondřej HRDÝ; Radka ŠTĚPÁNOVÁ et al.

Základní údaje

Originální název

ClotPro® haemostasis in pregnancy: physiological parameters, reference intervals and comparison with non-pregnant women in a prospective observational study

Autoři

Vydání

BMC Pregnancy and Childbirth, London, BMC, 2026, 1471-2393

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 2.700 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

DOI

UT WoS

EID Scopus

Klíčová slova anglicky

lumbar disc herniation; discectomy timing; surgical outcomes; preoperative symptom duration; cohort study

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 5. 5. 2026 13:24, Mgr. Tereza Miškechová

Anotace

V originále

Background Severe haemorrhage remains a leading cause of maternal mortality worldwide, despite advancements in obstetric care. Although viscoelastic testing is recommended to guide treatment of postpartum haemorrhage, device-specific physiological parameters and reference ranges specific to pregnancy are necessary to enable accurate interpretation of viscoelastic findings in the clinical management of obstetric patients. Evaluation of ClotPro®, including comparison with conventional laboratory assays and with non-pregnant individuals, is therefore essential to support its use in obstetric patients. Methods In this prospective study, venous blood samples were obtained from 130 parturient participants before labour and 45 non-pregnant controls. Samples were analysed with conventional laboratory coagulation tests and the ClotPro® device. ClotPro® parameters and conventional laboratory tests were compared between the parturient population and non-pregnant control group with Student’s t-test or the Mann-Whitney U test, as appropriate. The correlation between selected laboratory and coagulation parameters was assessed with Spearman’s correlation coefficient. Reference ranges for ClotPro® in parturients were established by calculation of percentiles 2.5 and 97.5. Results Significant statistical differences in clot firmness were found across the EX-test, IN-test, and FIB-test (p < 0.006) between parturient and non-pregnant participants. The most pronounced differences were observed in the FIB-test. Strong correlation was observed between conventional laboratory tests and FIB-test (Rs = 0.657, p < 0.001 in the pregnant group; Rs = 0.669, p < 0.001 in the control group). According to our findings, reference ranges were established for the parturient population: EX-test, CT (39–67 s), A5 (39–59 mm), ML (1–9%), MCF (57–70 mm); FIB-test, A5 (15–29 mm), MCF (19–35 mm); and IN-test, CT (121–172 s). Conclusion Pregnant women exhibit a distinct ClotPro® coagulation profile, characterised by increased clot firmness in FIB-test, supported by correlations with standard laboratory tests and parturient-specific reference intervals. These findings enhance the physiological interpretation of ClotPro® in obstetric care and may support its future integration into postpartum haemorrhage management.

Návaznosti

MUNI/A/1801/2025, interní kód MU
Název: Role fibrinogenu u pacientů s polytraumatem II
Investor: Masarykova univerzita, Role fibrinogenu u pacientů s polytraumatem II