Bat species tolerant and susceptible to fungal infection show
transcriptomic differences in late hibernation and healing

J 2026

Bat species tolerant and susceptible to fungal infection show transcriptomic differences in late hibernation and healing

WHITING-FAWCETT, Flora; Kenneth A FIELD; Tomáš BARTONIČKA; Veronika N LAINE; Jiří PIKULA et al.

Základní údaje

Originální název

Bat species tolerant and susceptible to fungal infection show transcriptomic differences in late hibernation and healing

Autoři

WHITING-FAWCETT, Flora; Kenneth A FIELD; Tomáš BARTONIČKA; Veronika N LAINE; Jiří PIKULA; Matthew E REPKE; Sara TALMAGE; Gregory TURNER; Jan ZUKAL; Steve PATERSON a Thomas M LILLEY

Vydání

Journal of Experimental Biology, Cambridge, Company of Biologists Ltd, 2026, 0022-0949

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10613 Zoology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.600 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Immune response; Immunopathology; Disease; Recovery; White-nose disease

Štítky

14314020, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 30. 4. 2026 15:28, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Much of the research into white-nose disease has focused on the hibernation period, while the pathogenic fungus Pseudogymnoascus destructans is actively infecting the bat host. Previous research has found large differences between the susceptible North American Myotis lucifugus and the tolerant European Myotis myotis, suggestive of immunopathology in the former, and a beneficial lack of strong response in the latter. Here, we examined gene expression in these species both during the late-hibernation period and a month after emergence from hibernation, during healing from infection. We utilised paired sampling, collecting wing tissue that was positive and negative for fungal infection fluorescence, to examine changes in wholetranscriptome gene expression that were local to sites of infection at two time points: pre-emergence and 30 days post-emergence from hibernation. Positive samples were contrasted between the two time points to examine longitudinal changes. During the pre-emergence period, local inflammatory responses were observed in both M. myotis and M. lucifugus. Immune responses between the tolerant and susceptible species were dissimilar, favouring Th1 and Th17 cytokine responses, respectively. This lends weight to immunopathology as a contributing factor to mortality in M. lucifugus. Continual immune responses may not only contribute to immunopathology and host mortality but also have important carry-over effects on reproduction and subsequent pre-winter fattening, affecting population viability over a longer period of time than previously considered.

Citovat

WHITING-FAWCETT, Flora; Kenneth A FIELD; Tomáš BARTONIČKA; Veronika N LAINE; Jiří PIKULA; Matthew E REPKE; Sara TALMAGE; Gregory TURNER; Jan ZUKAL; Steve PATERSON a Thomas M LILLEY. Bat species tolerant and susceptible to fungal infection show transcriptomic differences in late hibernation and healing. Journal of Experimental Biology. Cambridge: Company of Biologists Ltd, 2026, roč. 229, č. 1, s. 1-12. ISSN 0022-0949. Dostupné z: https://doi.org/10.1242/jeb.250903.

@article{2569366,
   author = {WhitingandFawcett, Flora and Field, Kenneth A and Bartonička, Tomáš and Laine, Veronika N and Pikula, Jiří and Repke, Matthew E and Talmage, Sara and Turner, Gregory and Zukal, Jan and Paterson, Steve and Lilley, Thomas M},
   article_location = {Cambridge},
   article_number = {1},
   doi = {https://doi.org/10.1242/jeb.250903},
   keywords = {Immune response; Immunopathology; Disease; Recovery; White-nose disease},
   language = {eng},
   issn = {0022-0949},
   journal = {Journal of Experimental Biology},
   title = {Bat species tolerant and susceptible to fungal infection show transcriptomic differences in late hibernation and healing},
   url = {https://journals.biologists.com/jeb/article-abstract/229/1/jeb250903/370281/Bat-species-tolerant-and-susceptible-to-fungal?redirectedFrom=fulltext},
   volume = {229},
   year = {2026}
}

TY  - JOUR
ID  - 2569366
AU  - Whiting-Fawcett, Flora - Field, Kenneth A - Bartonička, Tomáš - Laine, Veronika N - Pikula, Jiří - Repke, Matthew E - Talmage, Sara - Turner, Gregory - Zukal, Jan - Paterson, Steve - Lilley, Thomas M
PY  - 2026
TI  - Bat species tolerant and susceptible to fungal infection show transcriptomic differences in late hibernation and healing
JF  - Journal of Experimental Biology
VL  - 229
IS  - 1
SP  - 1-12
EP  - 1-12
PB  - Company of Biologists Ltd
SN  - 00220949
KW  - Immune response
KW  - Immunopathology
KW  - Disease
KW  - Recovery
KW  - White-nose disease
UR  - https://journals.biologists.com/jeb/article-abstract/229/1/jeb250903/370281/Bat-species-tolerant-and-susceptible-to-fungal?redirectedFrom=fulltext
N2  - Much of the research into white-nose disease has focused on the hibernation period, while the pathogenic fungus Pseudogymnoascus destructans is actively infecting the bat host. Previous research has found large differences between the susceptible North American Myotis lucifugus and the tolerant European Myotis myotis, suggestive of immunopathology in the former, and a beneficial lack of strong response in the latter. Here, we examined gene expression in these species both during the late-hibernation period and a month after emergence from hibernation, during healing from infection. We utilised paired sampling, collecting wing tissue that was positive and negative for fungal infection fluorescence, to examine changes in wholetranscriptome gene expression that were local to sites of infection at two time points: pre-emergence and 30 days post-emergence from hibernation. Positive samples were contrasted between the two time points to examine longitudinal changes. During the pre-emergence period, local inflammatory responses were observed in both M. myotis and M. lucifugus. Immune responses between the tolerant and susceptible species were dissimilar, favouring Th1 and Th17 cytokine responses, respectively. This lends weight to immunopathology as a contributing factor to mortality in M. lucifugus. Continual immune responses may not only contribute to immunopathology and host mortality but also have important carry-over effects on reproduction and subsequent pre-winter fattening, affecting population viability over a longer period of time than previously considered.
ER  -

WHITING-FAWCETT, Flora; Kenneth A FIELD; Tomáš BARTONIČKA; Veronika N LAINE; Jiří PIKULA; Matthew E REPKE; Sara TALMAGE; Gregory TURNER; Jan ZUKAL; Steve PATERSON a Thomas M LILLEY. Bat species tolerant and susceptible to fungal infection show transcriptomic differences in late hibernation and healing. \textit{Journal of Experimental Biology}. Cambridge: Company of Biologists Ltd, 2026, roč.~229, č.~1, s.~1-12. ISSN~0022-0949. Dostupné z: https://doi.org/10.1242/jeb.250903.

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