Clinical Characteristics, Management and Outcomes of Nonintensive Care Unit Candidemia: Subanalysis of the ECMM Candida III Multinational European Observational Cohort Study
WOLFGRUBER, Stella; Carolina GARCIA-VIDAL; Sarah SEDIK; Jon SALMANTON-GARCIA; Sevtap ARIKAN-AKDAGLI et al.
Clinical Characteristics, Management and Outcomes of Nonintensive Care Unit Candidemia: Subanalysis of the ECMM Candida III Multinational European Observational Cohort Study
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WOLFGRUBER, Stella; Carolina GARCIA-VIDAL; Sarah SEDIK; Jon SALMANTON-GARCIA; Sevtap ARIKAN-AKDAGLI; Jean-Pierre GANGNEUX; Riina RAUTEMAA-RICHARDSON; Valentina ARSIC-ARSENIJEVIC; Sonia MARTIN-PEREZ; Julio DAVILA-VALLS; Nurettin ERBEN; Emin Halis AKALIN; Lubos DRGONA; Cornelia LASS-FLORL; Julio GARCIA-RODRIGUEZ; Tihana BICANIC; Helena HAMMARSTROM; Petr HAMAL; Jorg STEINMANN; Eelco F J MEIJER; Nina KHANNA; Guillaume DESOUBEAUX; Thomas LONGVAL; Uluhan SILI; Janina TRAUTH; Matteo BASSETTI; P Lewis WHITE; Avinash AUJAYEB; Tadeja MATOS; Deniz AKYOL; Francois DANION; Katrien LAGROU; Benedict ROGERS; Maite RUIZ; Alena SIVÁKOVÁ; Malgorzata MIKULSKA; Michael SAMARKOS; Ola BLENNOW; Deborah E A LOCKHART; Blandine DENIS; Birgit WILLINGER; Van Dijk KARIN; Ulrike SCHARMANN; Anna L GOODMAN; Van Praet JENS; Manjusha NARAYANAN; Cristina TOSCANO; Laura LOUGHLIN; De Jonge Nick ALEXANDER; Alba RUIZ-GAITAN; Fanny LANTERNIER; Juergen PRATTES; Emmanuel ROILIDES; Alida Fe TALENTO; Aleksandra BARAC; Matthias EGGER; Maiken Cavling ARENDRUP; Philipp KOEHLER; Oliver A CORNELY a Martin HOENIGL
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OPEN FORUM INFECTIOUS DISEASES, CARY, OXFORD UNIV PRESS INC, 2026, 2328-8957
The European Confederation of Medical Mycology Candida III was a pan-European, multicenter observational study of adult patients with blood culture–proven candidemia. Among a total of 632 patients with candidemia across 64 institutions in 20 European countries, a subanalysis of 396 (63%) cases occurring outside the intensive care unit (ICU) was conducted. Compared with ICU patients, non-ICU patients had a higher comorbidity burden (median Charlson comorbidity index [CCI] 6 vs 5 in ICU patients, P = .006). Hematologic and oncologic malignancies were more frequent among non-ICU cases (45.5% vs 28.4%, P < .001), whereas both chronic kidney and cardiovascular disease were more prevalent in ICU patients (P < .001). Non-ICU patients had significantly lower mortality in Kaplan–Meier survival analysis (P > .001). Postsurgical non-ICU patients (n = 45) had the highest survival rate (73.3%, P = .003) and the longest hospital stay, even after excluding all cases with a fatal outcome before day 30. In non-ICU patients, older age, hemato-oncologic malignancies, chronic liver disease, and COVID-19 were all independently associated with mortality risk, while treatment consultation by an infectious disease or clinical microbiology consultant, and initial treatment with an echinocandin, respectively, higher EQUAL Candida scores were associated with lower mortality risk in the multivariable Cox regression models. In conclusion, despite higher comorbidity rates, non-ICU patients with candidemia had higher survival rates.
WOLFGRUBER, Stella; Carolina GARCIA-VIDAL; Sarah SEDIK; Jon SALMANTON-GARCIA; Sevtap ARIKAN-AKDAGLI; Jean-Pierre GANGNEUX; Riina RAUTEMAA-RICHARDSON; Valentina ARSIC-ARSENIJEVIC; Sonia MARTIN-PEREZ; Julio DAVILA-VALLS; Nurettin ERBEN; Emin Halis AKALIN; Lubos DRGONA; Cornelia LASS-FLORL; Julio GARCIA-RODRIGUEZ; Tihana BICANIC; Helena HAMMARSTROM; Petr HAMAL; Jorg STEINMANN; Eelco F J MEIJER; Nina KHANNA; Guillaume DESOUBEAUX; Thomas LONGVAL; Uluhan SILI; Janina TRAUTH; Matteo BASSETTI; P Lewis WHITE; Avinash AUJAYEB; Tadeja MATOS; Deniz AKYOL; Francois DANION; Katrien LAGROU; Benedict ROGERS; Maite RUIZ; Alena SIVÁKOVÁ; Malgorzata MIKULSKA; Michael SAMARKOS; Ola BLENNOW; Deborah E A LOCKHART; Blandine DENIS; Birgit WILLINGER; Van Dijk KARIN; Ulrike SCHARMANN; Anna L GOODMAN; Van Praet JENS; Manjusha NARAYANAN; Cristina TOSCANO; Laura LOUGHLIN; De Jonge Nick ALEXANDER; Alba RUIZ-GAITAN; Fanny LANTERNIER; Juergen PRATTES; Emmanuel ROILIDES; Alida Fe TALENTO; Aleksandra BARAC; Matthias EGGER; Maiken Cavling ARENDRUP; Philipp KOEHLER; Oliver A CORNELY a Martin HOENIGL. Clinical Characteristics, Management and Outcomes of Nonintensive Care Unit Candidemia: Subanalysis of the ECMM Candida III Multinational European Observational Cohort Study. OPEN FORUM INFECTIOUS DISEASES. CARY: OXFORD UNIV PRESS INC, 2026, roč. 13, č. 4, s. 1-12. ISSN 2328-8957. Dostupné z: https://doi.org/10.1093/ofid/ofag133.
@article{2570599, author = {Wolfgruber, Stella and GarciaandVidal, Carolina and Sedik, Sarah and SalmantonandGarcia, Jon and ArikanandAkdagli, Sevtap and Gangneux, JeanandPierre and RautemaaandRichardson, Riina and ArsicandArsenijevic, Valentina and MartinandPerez, Sonia and DavilaandValls, Julio and Erben, Nurettin and Akalin, Emin Halis and Drgona, Lubos and LassandFlorl, Cornelia and GarciaandRodriguez, Julio and Bicanic, Tihana and Hammarstrom, Helena and Hamal, Petr and Steinmann, Jorg and Meijer, Eelco F J and Khanna, Nina and Desoubeaux, Guillaume and Longval, Thomas and Sili, Uluhan and Trauth, Janina and Bassetti, Matteo and White, P Lewis and Aujayeb, Avinash and Matos, Tadeja and Akyol, Deniz and Danion, Francois and Lagrou, Katrien and Rogers, Benedict and Ruiz, Maite and Siváková, Alena and Mikulska, Malgorzata and Samarkos, Michael and Blennow, Ola and Lockhart, Deborah E A and Denis, Blandine and Willinger, Birgit and Karin, Van Dijk and Scharmann, Ulrike and Goodman, Anna L and Jens, Van Praet and Narayanan, Manjusha and Toscano, Cristina and Loughlin, Laura and Alexander, De Jonge Nick and RuizandGaitan, Alba and Lanternier, Fanny and Prattes, Juergen and Roilides, Emmanuel and Talento, Alida Fe and Barac, Aleksandra and Egger, Matthias and Arendrup, Maiken Cavling and Koehler, Philipp and Cornely, Oliver A and Hoenigl, Martin}, article_location = {CARY}, article_number = {4}, doi = {https://doi.org/10.1093/ofid/ofag133}, keywords = {candidemia; disease outcome; invasive fungal infections; non-ICU}, language = {eng}, issn = {2328-8957}, journal = {OPEN FORUM INFECTIOUS DISEASES}, title = {Clinical Characteristics, Management and Outcomes of Nonintensive Care Unit Candidemia: Subanalysis of the ECMM Candida III Multinational European Observational Cohort Study}, url = {https://academic.oup.com/ofid/article/13/4/ofag133/8541566}, volume = {13}, year = {2026} }
TY - JOUR ID - 2570599 AU - Wolfgruber, Stella - Garcia-Vidal, Carolina - Sedik, Sarah - Salmanton-Garcia, Jon - Arikan-Akdagli, Sevtap - Gangneux, Jean-Pierre - Rautemaa-Richardson, Riina - Arsic-Arsenijevic, Valentina - Martin-Perez, Sonia - Davila-Valls, Julio - Erben, Nurettin - Akalin, Emin Halis - Drgona, Lubos - Lass-Florl, Cornelia - Garcia-Rodriguez, Julio - Bicanic, Tihana - Hammarstrom, Helena - Hamal, Petr - Steinmann, Jorg - Meijer, Eelco F J - Khanna, Nina - Desoubeaux, Guillaume - Longval, Thomas - Sili, Uluhan - Trauth, Janina - Bassetti, Matteo - White, P Lewis - Aujayeb, Avinash - Matos, Tadeja - Akyol, Deniz - Danion, Francois - Lagrou, Katrien - Rogers, Benedict - Ruiz, Maite - Siváková, Alena - Mikulska, Malgorzata - Samarkos, Michael - Blennow, Ola - Lockhart, Deborah E A - Denis, Blandine - Willinger, Birgit - Karin, Van Dijk - Scharmann, Ulrike - Goodman, Anna L - Jens, Van Praet - Narayanan, Manjusha - Toscano, Cristina - Loughlin, Laura - Alexander, De Jonge Nick - Ruiz-Gaitan, Alba - Lanternier, Fanny - Prattes, Juergen - Roilides, Emmanuel - Talento, Alida Fe - Barac, Aleksandra - Egger, Matthias - Arendrup, Maiken Cavling - Koehler, Philipp - Cornely, Oliver A - Hoenigl, Martin PY - 2026 TI - Clinical Characteristics, Management and Outcomes of Nonintensive Care Unit Candidemia: Subanalysis of the ECMM Candida III Multinational European Observational Cohort Study JF - OPEN FORUM INFECTIOUS DISEASES VL - 13 IS - 4 SP - 1-12 EP - 1-12 PB - OXFORD UNIV PRESS INC SN - 23288957 KW - candidemia KW - disease outcome KW - invasive fungal infections KW - non-ICU UR - https://academic.oup.com/ofid/article/13/4/ofag133/8541566 N2 - The European Confederation of Medical Mycology Candida III was a pan-European, multicenter observational study of adult patients with blood culture–proven candidemia. Among a total of 632 patients with candidemia across 64 institutions in 20 European countries, a subanalysis of 396 (63%) cases occurring outside the intensive care unit (ICU) was conducted. Compared with ICU patients, non-ICU patients had a higher comorbidity burden (median Charlson comorbidity index [CCI] 6 vs 5 in ICU patients, P = .006). Hematologic and oncologic malignancies were more frequent among non-ICU cases (45.5% vs 28.4%, P < .001), whereas both chronic kidney and cardiovascular disease were more prevalent in ICU patients (P < .001). Non-ICU patients had significantly lower mortality in Kaplan–Meier survival analysis (P > .001). Postsurgical non-ICU patients (n = 45) had the highest survival rate (73.3%, P = .003) and the longest hospital stay, even after excluding all cases with a fatal outcome before day 30. In non-ICU patients, older age, hemato-oncologic malignancies, chronic liver disease, and COVID-19 were all independently associated with mortality risk, while treatment consultation by an infectious disease or clinical microbiology consultant, and initial treatment with an echinocandin, respectively, higher EQUAL Candida scores were associated with lower mortality risk in the multivariable Cox regression models. In conclusion, despite higher comorbidity rates, non-ICU patients with candidemia had higher survival rates. ER -
WOLFGRUBER, Stella; Carolina GARCIA-VIDAL; Sarah SEDIK; Jon SALMANTON-GARCIA; Sevtap ARIKAN-AKDAGLI; Jean-Pierre GANGNEUX; Riina RAUTEMAA-RICHARDSON; Valentina ARSIC-ARSENIJEVIC; Sonia MARTIN-PEREZ; Julio DAVILA-VALLS; Nurettin ERBEN; Emin Halis AKALIN; Lubos DRGONA; Cornelia LASS-FLORL; Julio GARCIA-RODRIGUEZ; Tihana BICANIC; Helena HAMMARSTROM; Petr HAMAL; Jorg STEINMANN; Eelco F J MEIJER; Nina KHANNA; Guillaume DESOUBEAUX; Thomas LONGVAL; Uluhan SILI; Janina TRAUTH; Matteo BASSETTI; P Lewis WHITE; Avinash AUJAYEB; Tadeja MATOS; Deniz AKYOL; Francois DANION; Katrien LAGROU; Benedict ROGERS; Maite RUIZ; Alena SIVÁKOVÁ; Malgorzata MIKULSKA; Michael SAMARKOS; Ola BLENNOW; Deborah E A LOCKHART; Blandine DENIS; Birgit WILLINGER; Van Dijk KARIN; Ulrike SCHARMANN; Anna L GOODMAN; Van Praet JENS; Manjusha NARAYANAN; Cristina TOSCANO; Laura LOUGHLIN; De Jonge Nick ALEXANDER; Alba RUIZ-GAITAN; Fanny LANTERNIER; Juergen PRATTES; Emmanuel ROILIDES; Alida Fe TALENTO; Aleksandra BARAC; Matthias EGGER; Maiken Cavling ARENDRUP; Philipp KOEHLER; Oliver A CORNELY a Martin HOENIGL. Clinical Characteristics, Management and Outcomes of Nonintensive Care Unit Candidemia: Subanalysis of the ECMM Candida III Multinational European Observational Cohort Study. \textit{OPEN FORUM INFECTIOUS DISEASES}. CARY: OXFORD UNIV PRESS INC, 2026, roč.~13, č.~4, s.~1-12. ISSN~2328-8957. Dostupné z: https://doi.org/10.1093/ofid/ofag133.