Local Field Aperiodic Spectral Power Modulated by Deep Brain
Stimulation in Parkinson's Disease

J 2026

Local Field Aperiodic Spectral Power Modulated by Deep Brain Stimulation in Parkinson's Disease

LAMOŠ, Martin; Aneta ŽÁČKOVÁ; David ULČÁK; Benjamín GURKA; Daniel BRZUCHANSKI et al.

Základní údaje

Originální název

Local Field Aperiodic Spectral Power Modulated by Deep Brain Stimulation in Parkinson's Disease

Autoři

LAMOŠ, Martin ; Aneta ŽÁČKOVÁ ; David ULČÁK ; Benjamín GURKA ; Daniel BRZUCHANSKI ; Lucia ŠMAHOVSKÁ a Martina BOČKOVÁ

Vydání

Movement Disorders, HOBOKEN, WILEY, 2026, 0885-3185

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.600 v roce 2024

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

aperiodic spectral components; deep brain stimulation; new biomarker; Parkinson's disease; STN-LFPs

Štítky

14110127

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 5. 2026 14:34, Mgr. Tereza Miškechová

Anotace

V originále

Background: Aperiodic spectral broadband power has been described recently as reflecting Parkinson's disease (PD) severity. It has therefore become an increasing focus of research interest in the context of the new adaptive deep brain stimulation (DBS) approach. Objective: We aimed to study the influence of DBS on the main parameters of the aperiodic spectral component of local field potentials (LFPs). Methods: LFPs were recorded from the subthalamic nucleus (STN) in patients with PD (n = 22) during a simple experimental paradigm that included 5 minutes of resting state and a short gait task during DBS OFF and ON conditions (off medication). Classical spectral analysis was performed using fast Fourier transform; the analysis of the aperiodic component was performed by fitting oscillations and a one-over-F approach. In a subset of the patients (n = 14), it was possible to evaluate the symptom progression over time after 1 year by analyzing the control measurement. Results: The severity of hypokinetic/rigid symptomatology, measured by International Parkinson and Movement Disorders Society Unified Parkinson's Disease Rating Scale, correlated significantly with both of the aperiodic components characteristics of the STN LFPs: the slope and the offset. These parameters were significantly modified by DBS, as evaluated with a Wilcoxon signed-rank test during the resting state and during the gait task. Aperiodic power remained stable over time during the control measurements. Conclusions: The aperiodic component in LFPs may reflect pathological activity of the neuronal network and might serve as a new potential clinical marker in PD. The variable relation to conventional beta oscillopathy indicates the involvement of multiple neural mechanisms. (c) 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Návaznosti

LX22NPO5107, projekt VaV

Název: Národní ústav pro neurologický výzkum

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní ústav pro neurologický výzkum, 5.1 EXCELES

NU21-04-00445, projekt VaV

Název: Klinická odpovídavost na STN-DBS u Parkinsonovy nemoci: vliv vaskulárních, kardiovaskulárních, metabolických a zánětlivých komorbidit (Akronym: DBScomorbidities)

Investor: Ministerstvo zdravotnictví ČR, Klinická odpovídavost na STN-DBS u Parkinsonovy nemoci: vliv vaskulárních, kardiovaskulárních, metabolických a zánětlivých komorbidit, Podprogram 1 - standardní

Citovat

LAMOŠ, Martin; Aneta ŽÁČKOVÁ; David ULČÁK; Benjamín GURKA; Daniel BRZUCHANSKI; Lucia ŠMAHOVSKÁ a Martina BOČKOVÁ. Local Field Aperiodic Spectral Power Modulated by Deep Brain Stimulation in Parkinson's Disease. Movement Disorders. HOBOKEN: WILEY, 2026, 10 s. ISSN 0885-3185. Dostupné z: https://doi.org/10.1002/mds.70232.

@article{2570621,
   author = {Lamoš, Martin and Žáčková, Aneta and Ulčák, David and Gurka, Benjamín and Brzuchanski, Daniel and Šmahovská, Lucia and Bočková, Martina},
   article_location = {HOBOKEN},
   doi = {https://doi.org/10.1002/mds.70232},
   keywords = {aperiodic spectral components; deep brain stimulation; new biomarker; Parkinson's disease; STN-LFPs},
   language = {eng},
   issn = {0885-3185},
   journal = {Movement Disorders},
   title = {Local Field Aperiodic Spectral Power Modulated by Deep Brain Stimulation in Parkinson's Disease},
   url = {https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.70232},
   year = {2026}
}

TY  - JOUR
ID  - 2570621
AU  - Lamoš, Martin - Žáčková, Aneta - Ulčák, David - Gurka, Benjamín - Brzuchanski, Daniel - Šmahovská, Lucia - Bočková, Martina
PY  - 2026
TI  - Local Field Aperiodic Spectral Power Modulated by Deep Brain Stimulation in Parkinson's Disease
JF  - Movement Disorders
PB  - WILEY
SN  - 08853185
KW  - aperiodic spectral components
KW  - deep brain stimulation
KW  - new biomarker
KW  - Parkinson's disease
KW  - STN-LFPs
UR  - https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.70232
N2  - Background: Aperiodic spectral broadband power has been described recently as reflecting Parkinson's disease (PD) severity. It has therefore become an increasing focus of research interest in the context of the new adaptive deep brain stimulation (DBS) approach. Objective: We aimed to study the influence of DBS on the main parameters of the aperiodic spectral component of local field potentials (LFPs). Methods: LFPs were recorded from the subthalamic nucleus (STN) in patients with PD (n = 22) during a simple experimental paradigm that included 5 minutes of resting state and a short gait task during DBS OFF and ON conditions (off medication). Classical spectral analysis was performed using fast Fourier transform; the analysis of the aperiodic component was performed by fitting oscillations and a one-over-F approach. In a subset of the patients (n = 14), it was possible to evaluate the symptom progression over time after 1 year by analyzing the control measurement. Results: The severity of hypokinetic/rigid symptomatology, measured by International Parkinson and Movement Disorders Society Unified Parkinson's Disease Rating Scale, correlated significantly with both of the aperiodic components characteristics of the STN LFPs: the slope and the offset. These parameters were significantly modified by DBS, as evaluated with a Wilcoxon signed-rank test during the resting state and during the gait task. Aperiodic power remained stable over time during the control measurements. Conclusions: The aperiodic component in LFPs may reflect pathological activity of the neuronal network and might serve as a new potential clinical marker in PD. The variable relation to conventional beta oscillopathy indicates the involvement of multiple neural mechanisms. (c) 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
ER  -

LAMOŠ, Martin; Aneta ŽÁČKOVÁ; David ULČÁK; Benjamín GURKA; Daniel BRZUCHANSKI; Lucia ŠMAHOVSKÁ a Martina BOČKOVÁ. Local Field Aperiodic Spectral Power Modulated by Deep Brain Stimulation in Parkinson's Disease. \textit{Movement Disorders}. HOBOKEN: WILEY, 2026, 10 s. ISSN~0885-3185. Dostupné z: https://doi.org/10.1002/mds.70232.

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