When probiotics turn deadly: a case of Lacticaseibacillus
rhamnosus sepsis in a burn patient

J 2026

When probiotics turn deadly: a case of Lacticaseibacillus rhamnosus sepsis in a burn patient

JANAK, David; Bohumil BAKALAR; Marta FRIDRICHOVA; Barbora ZWINSOVÁ; Robert ZAJICEK et al.

Základní údaje

Originální název

When probiotics turn deadly: a case of Lacticaseibacillus rhamnosus sepsis in a burn patient

Autoři

JANAK, David; Bohumil BAKALAR; Marta FRIDRICHOVA; Barbora ZWINSOVÁ ; Robert ZAJICEK; Břetislav LIPOVÝ a Petra BOŘILOVÁ LINHARTOVÁ

Vydání

Folia Microbiologica, Springer, 2026, 0015-5632

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10606 Microbiology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.100 v roce 2024

Označené pro přenos do RIV

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Lacticaseibacillus rhamnosus; Sepsis; Probiotics; Burns

Štítky

143180

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 5. 2026 14:03, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

We report the first comprehensive documented case of sepsis caused by Lacticaseibacillus rhamnosus infection, likely resulting from high-dose probiotic supplementation. This sepsis occured in a 36-year-old woman with deep partial- and full-thickness burns covering 25% of total body surface area. The use of probiotics in patients with organ dysfunction and in immunocompromised individuals is on the rise. The immune system and intestinal barriers are often compromised in patients with burns, which may facilitate the translocation of probiotic bacteria into bloodstream and lead to bacteremia; however, isolation of lactobacilli in blood cultures is often disregarded and considered an artefact caused by contamination. This case highlights that probiotic-associated L. rhamnosus sepsis, although rare, can occur in these patients and excessive probiotic use should therefore be avoided in these individuals.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

LM2023069, projekt VaV

Název: Výzkumná infrastruktura RECETOX

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

90254, velká výzkumná infrastruktura

Název: e-INFRA CZ II

90267, velká výzkumná infrastruktura

Název: NCMG III

Citovat

JANAK, David; Bohumil BAKALAR; Marta FRIDRICHOVA; Barbora ZWINSOVÁ; Robert ZAJICEK; Břetislav LIPOVÝ a Petra BOŘILOVÁ LINHARTOVÁ. When probiotics turn deadly: a case of Lacticaseibacillus rhamnosus sepsis in a burn patient. Folia Microbiologica. Springer, 2026, 6 s. ISSN 0015-5632. Dostupné z: https://doi.org/10.1007/s12223-026-01445-x.

@article{2571797,
   author = {Janak, David and Bakalar, Bohumil and Fridrichova, Marta and Zwinsová, Barbora and Zajicek, Robert and Lipový, Břetislav and Bořilová Linhartová, Petra},
   doi = {https://doi.org/10.1007/s12223-026-01445-x},
   keywords = {Lacticaseibacillus rhamnosus; Sepsis; Probiotics; Burns},
   language = {eng},
   issn = {0015-5632},
   journal = {Folia Microbiologica},
   title = {When probiotics turn deadly: a case of Lacticaseibacillus rhamnosus sepsis in a burn patient},
   url = {https://link.springer.com/article/10.1007/s12223-026-01445-x},
   year = {2026}
}

TY  - JOUR
ID  - 2571797
AU  - Janak, David - Bakalar, Bohumil - Fridrichova, Marta - Zwinsová, Barbora - Zajicek, Robert - Lipový, Břetislav - Bořilová Linhartová, Petra
PY  - 2026
TI  - When probiotics turn deadly: a case of Lacticaseibacillus rhamnosus sepsis in a burn patient
JF  - Folia Microbiologica
PB  - Springer
SN  - 00155632
KW  - Lacticaseibacillus rhamnosus
KW  - Sepsis
KW  - Probiotics
KW  - Burns
UR  - https://link.springer.com/article/10.1007/s12223-026-01445-x
N2  - We report the first comprehensive documented case of sepsis caused by Lacticaseibacillus rhamnosus infection, likely resulting from high-dose probiotic supplementation. This sepsis occured in a 36-year-old woman with deep partial- and full-thickness burns covering 25% of total body surface area. The use of probiotics in patients with organ dysfunction and in immunocompromised individuals is on the rise. The immune system and intestinal barriers are often compromised in patients with burns, which may facilitate the translocation of probiotic bacteria into bloodstream and lead to bacteremia; however, isolation of lactobacilli in blood cultures is often disregarded and considered an artefact caused by contamination. This case highlights that probiotic-associated L. rhamnosus sepsis, although rare, can occur in these patients and excessive probiotic use should therefore be avoided in these individuals.
ER  -

JANAK, David; Bohumil BAKALAR; Marta FRIDRICHOVA; Barbora ZWINSOVÁ; Robert ZAJICEK; Břetislav LIPOVÝ a Petra BOŘILOVÁ LINHARTOVÁ. When probiotics turn deadly: a case of Lacticaseibacillus rhamnosus sepsis in a burn patient. \textit{Folia Microbiologica}. Springer, 2026, 6 s. ISSN~0015-5632. Dostupné z: https://doi.org/10.1007/s12223-026-01445-x.

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