Urinary biomarkers of urolithiasis risk in Crohn's disease:
hyperoxaluria, hypocitraturia, and hypomagnesuria in patients
with and without ileocolic resection

J 2026

Urinary biomarkers of urolithiasis risk in Crohn's disease: hyperoxaluria, hypocitraturia, and hypomagnesuria in patients with and without ileocolic resection

NAVRATIL, Vit; Barbora PIPEK; Premysl FALT; Jana ZAPLETALOVA; Jan KRIVINKA et al.

Základní údaje

Originální název

Urinary biomarkers of urolithiasis risk in Crohn's disease: hyperoxaluria, hypocitraturia, and hypomagnesuria in patients with and without ileocolic resection

Autoři

NAVRATIL, Vit; Barbora PIPEK; Premysl FALT; Jana ZAPLETALOVA; Jan KRIVINKA; Virginia SOLITANO a Lumír KUNOVSKÝ

Vydání

CROHNS & COLITIS 360, OXFORD, OXFORD UNIV PRESS, 2026, 2631-827X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30219 Gastroenterology and hepatology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.600 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

IBD; Crohn's disease; urolithiasis; nephrolithiasis; oxaluria; citraturia; magnesium

Štítky

14110223, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 6. 2026 13:19, Mgr. Tereza Miškechová

Anotace

V originále

Background/aims Patients with Crohn's disease (CD) are at an increased risk of urolithiasis, particularly after ileocolic (IC) resection. This study aimed to investigate the prevalence of hyperoxaluria, hypocitraturia, and hypomagnesuria in CD patients with and without IC resection, compared to healthy controls.Methods This cross-sectional study included three groups: CD patients who had undergone IC resection (group 1), CD patients with IC involvement but without active inflammation and without resection (group 2), and healthy controls (group 3). Each participant collected a 24-hour urine sample for analysis of oxalate, citrate, and magnesium excretion.Results A total of 107 participants were enrolled (34 in group 1, 42 in group 2, and 31 in group 3). The prevalence of hyperoxaluria was 26.5% in group 1, 35.7% in group 2, and 29.0% in group 3, with no significant differences between groups (P = .664). Hypocitraturia was more common in CD groups: 35.3% in group 1, 31.0% in group 2, compared to 9.7% in controls, with a significant difference from controls (P = .034). A significant difference in hypomagnesuria was found in group 1 compared to groups 2 and 3 (P = .001).Conclusion While hyperoxaluria prevalence was similar across groups, hypocitraturia and hypomagnesuria were more frequent in CD patients, particularly those with IC resection. Monitoring these biomarkers may help identify at-risk individuals and guide prevention of urolithiasis in CD.

Citovat

NAVRATIL, Vit; Barbora PIPEK; Premysl FALT; Jana ZAPLETALOVA; Jan KRIVINKA; Virginia SOLITANO a Lumír KUNOVSKÝ. Urinary biomarkers of urolithiasis risk in Crohn's disease: hyperoxaluria, hypocitraturia, and hypomagnesuria in patients with and without ileocolic resection. CROHNS & COLITIS 360. OXFORD: OXFORD UNIV PRESS, 2026, roč. 8, č. 2, s. 1-9. ISSN 2631-827X. Dostupné z: https://doi.org/10.1093/crocol/otag033.

@article{2577888,
   author = {Navratil, Vit and Pipek, Barbora and Falt, Premysl and Zapletalova, Jana and Krivinka, Jan and Solitano, Virginia and Kunovský, Lumír},
   article_location = {OXFORD},
   article_number = {2},
   doi = {https://doi.org/10.1093/crocol/otag033},
   keywords = {IBD; Crohn's disease; urolithiasis; nephrolithiasis; oxaluria; citraturia; magnesium},
   language = {eng},
   issn = {2631-827X},
   journal = {CROHNS & COLITIS 360},
   title = {Urinary biomarkers of urolithiasis risk in Crohn's disease: hyperoxaluria, hypocitraturia, and hypomagnesuria in patients with and without ileocolic resection},
   url = {https://academic.oup.com/crohnscolitis360/article/8/2/otag033/8661461},
   volume = {8},
   year = {2026}
}

TY  - JOUR
ID  - 2577888
AU  - Navratil, Vit - Pipek, Barbora - Falt, Premysl - Zapletalova, Jana - Krivinka, Jan - Solitano, Virginia - Kunovský, Lumír
PY  - 2026
TI  - Urinary biomarkers of urolithiasis risk in Crohn's disease: hyperoxaluria, hypocitraturia, and hypomagnesuria in patients with and without ileocolic resection
JF  - CROHNS & COLITIS 360
VL  - 8
IS  - 2
SP  - 1-9
EP  - 1-9
PB  - OXFORD UNIV PRESS
SN  - 2631827X
KW  - IBD
KW  - Crohn's disease
KW  - urolithiasis
KW  - nephrolithiasis
KW  - oxaluria
KW  - citraturia
KW  - magnesium
UR  - https://academic.oup.com/crohnscolitis360/article/8/2/otag033/8661461
N2  - Background/aims Patients with Crohn's disease (CD) are at an increased risk of urolithiasis, particularly after ileocolic (IC) resection. This study aimed to investigate the prevalence of hyperoxaluria, hypocitraturia, and hypomagnesuria in CD patients with and without IC resection, compared to healthy controls.Methods This cross-sectional study included three groups: CD patients who had undergone IC resection (group 1), CD patients with IC involvement but without active inflammation and without resection (group 2), and healthy controls (group 3). Each participant collected a 24-hour urine sample for analysis of oxalate, citrate, and magnesium excretion.Results A total of 107 participants were enrolled (34 in group 1, 42 in group 2, and 31 in group 3). The prevalence of hyperoxaluria was 26.5% in group 1, 35.7% in group 2, and 29.0% in group 3, with no significant differences between groups (P = .664). Hypocitraturia was more common in CD groups: 35.3% in group 1, 31.0% in group 2, compared to 9.7% in controls, with a significant difference from controls (P = .034). A significant difference in hypomagnesuria was found in group 1 compared to groups 2 and 3 (P = .001).Conclusion While hyperoxaluria prevalence was similar across groups, hypocitraturia and hypomagnesuria were more frequent in CD patients, particularly those with IC resection. Monitoring these biomarkers may help identify at-risk individuals and guide prevention of urolithiasis in CD.
ER  -

NAVRATIL, Vit; Barbora PIPEK; Premysl FALT; Jana ZAPLETALOVA; Jan KRIVINKA; Virginia SOLITANO a Lumír KUNOVSKÝ. Urinary biomarkers of urolithiasis risk in Crohn's disease: hyperoxaluria, hypocitraturia, and hypomagnesuria in patients with and without ileocolic resection. \textit{CROHNS \&{} COLITIS 360}. OXFORD: OXFORD UNIV PRESS, 2026, roč.~8, č.~2, s.~1-9. ISSN~2631-827X. Dostupné z: https://doi.org/10.1093/crocol/otag033.

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