Fibrinogen as a predictor of intracranial hemorrhage after
intravenous thrombolysis in ischemic stroke

J 2026

Fibrinogen as a predictor of intracranial hemorrhage after intravenous thrombolysis in ischemic stroke

SIMUNEK, L.; Veronika KUNEŠOVÁ; Robert MIKULÍK a R. HERZIG

Základní údaje

Originální název

Fibrinogen as a predictor of intracranial hemorrhage after intravenous thrombolysis in ischemic stroke

Autoři

SIMUNEK, L.; Veronika KUNEŠOVÁ; Robert MIKULÍK a R. HERZIG

Vydání

Ceska a slovenska neurologie a neurochirurgie, PRAGUE, CZECH MEDICAL SOC, 2026, 1210-7859

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30230 Other clinical medicine subjects

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

STROKE

Impakt faktor

Impact factor: 0.400 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.48095/cccsnn202663

UT WoS

001734095000001

Klíčová slova česky

stroke; ischemia; sis; fibrinogen; intracranial hemorrhage; parenchymal hematoma

Klíčová slova anglicky

stroke; ischemia; sis; fibrinogen; intracranial hemorrhage; parenchymal hematoma

Štítky

CZECRIN, Excelence Science, user, článek v časopise

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 6. 2026 14:41, Bc. Hana Vladíková, BBA

Anotace

V originále

Backgroundandobjective:Although intravenous thrombolysis(IVT) isa recommended recanalization therapy for ischemic stroke, it is associated with a risk of symptomatic intracranial hemorrhage. This academic clinical study aims to evaluate the relationship between fibrinogen levels and their drop measured at 6 and 24 h after IVT and the risk of intracranial hemorrhage, specifically parenchymal hematoma, which is the most clinically significant type of intracranial hemorrhage. Methods: Seven primary stroke centers and comprehensive stroke centers in the Czech Republic will be involved in the multicenter retrospective study. The estimated total number of patients enrolled in the observation and control groups is 300, with defined entry parameters maintained. The parameters monitored include personal and pharmacological history, laboratory parameters, neurological findings, and imaging results. Results: The study will evaluate the degree of association between fibrinogen levels and their drop measured at 6 and 24 h after IVT and the risk of parenchymal hematoma. Conclusion: Evidence of an association between the development of parenchymal hematoma and a decrease in fibrinogen levels in patients with ischemic stroke treated with IVT may be used to design an interventional study with fibrinogen replacement to prevent bleeding.

Návaznosti

90249, velká výzkumná infrastruktura

Název: CZECRIN IV

Citovat

SIMUNEK, L.; Veronika KUNEŠOVÁ; Robert MIKULÍK a R. HERZIG. Fibrinogen as a predictor of intracranial hemorrhage after intravenous thrombolysis in ischemic stroke. Ceska a slovenska neurologie a neurochirurgie. PRAGUE: CZECH MEDICAL SOC, 2026, roč. 89, č. 1, s. 63-67. ISSN 1210-7859. Dostupné z: https://doi.org/10.48095/cccsnn202663.

@article{2579338,
   author = {Simunek, L. and Kunešová, Veronika and Mikulík, Robert and Herzig, R.},
   article_location = {PRAGUE},
   article_number = {1},
   doi = {https://doi.org/10.48095/cccsnn202663},
   keywords = {stroke; ischemia; sis; fibrinogen; intracranial hemorrhage; parenchymal hematoma},
   language = {eng},
   issn = {1210-7859},
   journal = {Ceska a slovenska neurologie a neurochirurgie},
   title = {Fibrinogen as a predictor of intracranial hemorrhage after intravenous thrombolysis in ischemic stroke},
   url = {https://www.csnn.eu/en/journals/czech-and-slovak-neurology-and-neurosurgery/2026-1/fibrinogen-as-a-predictor-of-intracranial-hemorrhage-after-intravenous-thrombolysis-in-ischemic-stroke-143155},
   volume = {89},
   year = {2026}
}

TY  - JOUR
ID  - 2579338
AU  - Simunek, L. - Kunešová, Veronika - Mikulík, Robert - Herzig, R.
PY  - 2026
TI  - Fibrinogen as a predictor of intracranial hemorrhage after intravenous thrombolysis in ischemic stroke
JF  - Ceska a slovenska neurologie a neurochirurgie
VL  - 89
IS  - 1
SP  - 63-67
EP  - 63-67
PB  - CZECH MEDICAL SOC
SN  - 12107859
KW  - stroke
KW  - ischemia
KW  - sis
KW  - fibrinogen
KW  - intracranial hemorrhage
KW  - parenchymal hematoma
UR  - https://www.csnn.eu/en/journals/czech-and-slovak-neurology-and-neurosurgery/2026-1/fibrinogen-as-a-predictor-of-intracranial-hemorrhage-after-intravenous-thrombolysis-in-ischemic-stroke-143155
N2  - Backgroundandobjective:Although intravenous thrombolysis(IVT) isa recommended recanalization therapy for ischemic stroke, it is associated with a risk of symptomatic intracranial hemorrhage. This academic clinical study aims to evaluate the relationship between fibrinogen levels and their drop measured at 6 and 24 h after IVT and the risk of intracranial hemorrhage, specifically parenchymal hematoma, which is the most clinically significant type of intracranial hemorrhage. Methods: Seven primary stroke centers and comprehensive stroke centers in the Czech Republic will be involved in the multicenter retrospective study. The estimated total number of patients enrolled in the observation and control groups is 300, with defined entry parameters maintained. The parameters monitored include personal and pharmacological history, laboratory parameters, neurological findings, and imaging results. Results: The study will evaluate the degree of association between fibrinogen levels and their drop measured at 6 and 24 h after IVT and the risk of parenchymal hematoma. Conclusion: Evidence of an association between the development of parenchymal hematoma and a decrease in fibrinogen levels in patients with ischemic stroke treated with IVT may be used to design an interventional study with fibrinogen replacement to prevent bleeding.
ER  -

SIMUNEK, L.; Veronika KUNEŠOVÁ; Robert MIKULÍK a R. HERZIG. Fibrinogen as a predictor of intracranial hemorrhage after intravenous thrombolysis in ischemic stroke. \textit{Ceska a slovenska neurologie a neurochirurgie}. PRAGUE: CZECH MEDICAL SOC, 2026, roč.~89, č.~1, s.~63-67. ISSN~1210-7859. Dostupné z: https://doi.org/10.48095/cccsnn202663.

Přehled o publikaci