ZELENKOVÁ, Olga, Eva HADAŠOVÁ, Eva ČEŠKOVÁ, Marie VOJTÍŠKOVÁ a Marie HYKSOVÁ. Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations. Human Psychopharmacol. 2000, roč. 2000, č. 4, s. 303-305. ISSN 0885-6222. |
Další formáty:
BibTeX
LaTeX
RIS
@article{321831, author = {Zelenková, Olga and Hadašová, Eva and Češková, Eva and Vojtíšková, Marie and Hyksová, Marie}, article_number = {4}, keywords = {Pharmacogenetics; CYP2D6 polymorphism; Dextromethorphan; Psychotropics}, language = {eng}, issn = {0885-6222}, journal = {Human Psychopharmacol.}, note = {Letter to the Editor}, title = {Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations}, volume = {2000}, year = {2000} }
TY - JOUR ID - 321831 AU - Zelenková, Olga - Hadašová, Eva - Češková, Eva - Vojtíšková, Marie - Hyksová, Marie PY - 2000 TI - Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations JF - Human Psychopharmacol. VL - 2000 IS - 4 SP - 303 EP - 303 SN - 08856222 N1 - Letter to the Editor KW - Pharmacogenetics KW - CYP2D6 polymorphism KW - Dextromethorphan KW - Psychotropics N2 - Twenty psychiatric patients were investigated for their CYP2D6 genotype and phenotype. Eight patients were pretreated with CYP2D6 substrate drugs, another 12 were therapy free. Genotyping with PCR for mutations in exon 3, 4 and 5 of CYP2D6 gene detected 65% of patients as heterozygously mutated in exon 4. The phenotyping test showed a significantly higher occurence of poor metabolizers in patients pretreated with CYP2D6 substrate drugs that within those without previous therapy. ER -
ZELENKOVÁ, Olga, Eva HADAŠOVÁ, Eva ČEŠKOVÁ, Marie VOJTÍŠKOVÁ a Marie HYKSOVÁ. Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations. \textit{Human Psychopharmacol.}. 2000, roč.~2000, č.~4, s.~303-305. ISSN~0885-6222.
|