| KAŠPÁRKOVÁ, Jana, Nicholas FARRELL a Viktor BRABEC. Sequence specificity, conformation, and recognition by HMG1 protein of major DNA interstrand cross-links of antitumor dinuclear platinum complexes. Journal of Biological Chemistry. Bethesda, USA: Amer. Soc. Biochem. Mol. Biol., roč. 275, č. 21, s. 15789-15799. ISSN 0021-9258. 2000. |
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@article{328491,
author = {Kašpárková, Jana and Farrell, Nicholas and Brabec, Viktor},
article_location = {Bethesda, USA},
article_number = {21},
language = {eng},
issn = {0021-9258},
journal = {Journal of Biological Chemistry},
title = {Sequence specificity, conformation, and recognition by HMG1 protein of major DNA interstrand cross-links of antitumor dinuclear platinum complexes},
volume = {275},
year = {2000}
}
TY - JOUR
ID - 328491
AU - Kašpárková, Jana - Farrell, Nicholas - Brabec, Viktor
PY - 2000
TI - Sequence specificity, conformation, and recognition by HMG1 protein of major DNA interstrand cross-links of antitumor dinuclear platinum complexes
JF - Journal of Biological Chemistry
VL - 275
IS - 21
SP - 15789
EP - 15789
PB - Amer. Soc. Biochem. Mol. Biol.
SN - 00219258
N2 - Interactions of high mobility group (HMG)-domain proteins with DNA modified by cisplatin plays a role in mechanisms underlying its antitumor activity. A structural motif recognized by HMG-domain proteins on cisplatin-modified DNA is a stable, directional bend of the helix axis. In the present work, bending induced in DNA by major adducts of a novel class of antitumor compounds, represented by the formula [{trans-[PtCl(NH3)2}H2N(CH2)2-6NH2]Cl2, was investigated. Gel retardation assay revealed very weak recognition of DNA adducts of dinuclear complexes by HMG1 protein. Hence, the mediation of antitumor properties of dinuclear platinum complexes by HMG-domain proteins is unlikely so that polynuclear platinum compounds may represent a novel class of platinum anticancer drugs acting by a different mechanism than cisplatin and its analogues.
ER -
KAŠPÁRKOVÁ, Jana, Nicholas FARRELL a Viktor BRABEC. Sequence specificity, conformation, and recognition by HMG1 protein of major DNA interstrand cross-links of antitumor dinuclear platinum complexes. \textit{Journal of Biological Chemistry}. Bethesda, USA: Amer. Soc. Biochem. Mol. Biol., roč.~275, č.~21, s.~15789-15799. ISSN~0021-9258. 2000.
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