| KOSTRHUNOVÁ, Hana a Viktor BRABEC. Conformational analysis of site-specific DNA cross-links of cisplatin-distamycin conjugates. Biochemistry. Washington, USA: American Chemical Society, 2000, roč. 2000, č. 39, s. 12639-12649. ISSN 0006-2960. |
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@article{337011,
author = {Kostrhunová, Hana and Brabec, Viktor},
article_location = {Washington, USA},
article_number = {39},
language = {eng},
issn = {0006-2960},
journal = {Biochemistry},
title = {Conformational analysis of site-specific DNA cross-links of cisplatin-distamycin conjugates},
volume = {2000},
year = {2000}
}
TY - JOUR
ID - 337011
AU - Kostrhunová, Hana - Brabec, Viktor
PY - 2000
TI - Conformational analysis of site-specific DNA cross-links of cisplatin-distamycin conjugates
JF - Biochemistry
VL - 2000
IS - 39
SP - 12639
EP - 12639
PB - American Chemical Society
SN - 00062960
N2 - The requirement for novel platinum antitumor drugs led to the concept of synthesis of novel platinum antitumor complexes based on the targeting cisplatin to various carrier molecules. In order to understand the molecular mechanisms underlying the biological activity of this new class of platinum compounds, studies of modifications of synthetic oligodeoxyribonucleotide duplexes by cisplatin tethered to the oligopeptide DNA minor groove binder distamycin were initiated. The results have indicated that the attachment of distamycin to cisplatin has no essential effect on intrastrand cross-linking of the parent platinum drug between adjacent purine residues. In contrast, tethering cisplatin to distamycin affects the sites preferentially involved in the interstrand cross-links.
ER -
KOSTRHUNOVÁ, Hana a Viktor BRABEC. Conformational analysis of site-specific DNA cross-links of cisplatin-distamycin conjugates. \textit{Biochemistry}. Washington, USA: American Chemical Society, 2000, roč.~2000, č.~39, s.~12639-12649. ISSN~0006-2960.
|
