Telomerase activity and expression in the course of treatment
of acute childhood leukemias

D 2000

Telomerase activity and expression in the course of treatment of acute childhood leukemias

MALÁSKA, Jan, Jiří FAJKUS, Milan BAJER, Hana HRSTKOVÁ, Kateřina BAJEROVÁ et. al.

Basic information

Original name

Telomerase activity and expression in the course of treatment of acute childhood leukemias

Authors

MALÁSKA, Jan (203 Czech Republic), Jiří FAJKUS (203 Czech Republic, guarantor), Milan BAJER (203 Czech Republic), Hana HRSTKOVÁ (203 Czech Republic), Kateřina BAJEROVÁ (203 Czech Republic), Jaroslav MICHÁLEK (203 Czech Republic), Lenka FAJKUSOVÁ (203 Czech Republic), Rostislav VYZULA (203 Czech Republic), Kateřina KREJČÍ (203 Czech Republic) and Marie SKLENIČKOVÁ (203 Czech Republic)

Edition

2000. vyd. Oxford, Miami Nature Biotechnology Short Reporřts, Volume 11m, Advances in Gene Technology: DNA, RNA and CANCER, p. 29a, 1 pp. 2000

Publisher

Oxford University Press

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

Genetics and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 11.542

RIV identification code

RIV/00216224:14310/00:00002452

Organization unit

Faculty of Science

ISSN

Keywords in English

Telomerase activity

Abstract

V originále

Samples of blood and marrow from children with leukemia were assayed for telomerase activity and expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis; it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, suggesting involvement of a telomerase-independent mechanism of telomere elongation.

Links

GA301/99/0045, research and development project

Name: Dynamika telomer u vybraných typů solidních maligních onemocnění

Investor: Czech Science Foundation, Telomere dynamics in selected types of solid malignant diseases

MSM 143100008, plan (intention)

Name: Genomy a jejich funkce

Investor: Ministry of Education, Youth and Sports of the CR, Genomes and their functions

VS97032, research and development project

Name: Analýza biologicky významných molekulárních komplexů

Investor: Ministry of Education, Youth and Sports of the CR, Analysis of biologically important molecular complexes

Citovat

MALÁSKA, Jan, Jiří FAJKUS, Milan BAJER, Hana HRSTKOVÁ, Kateřina BAJEROVÁ, Jaroslav MICHÁLEK, Lenka FAJKUSOVÁ, Rostislav VYZULA, Kateřina KREJČÍ and Marie SKLENIČKOVÁ. Telomerase activity and expression in the course of treatment of acute childhood leukemias. In Miami Nature Biotechnology Short Reporřts, Volume 11m, Advances in Gene Technology: DNA, RNA and CANCER. 2000th ed. Oxford: Oxford University Press, 2000, p. 29a, 1 pp. ISSN 1087-0156.

@inproceedings{343215,
   author = {Maláska, Jan and Fajkus, Jiří and Bajer, Milan and Hrstková, Hana and Bajerová, Kateřina and Michálek, Jaroslav and Fajkusová, Lenka and Vyzula, Rostislav and Krejčí, Kateřina and Skleničková, Marie},
   address = {Oxford},
   booktitle = {Miami Nature Biotechnology Short Reporřts, Volume 11m, Advances in Gene Technology: DNA, RNA and CANCER},
   edition = {2000},
   keywords = {Telomerase activity},
   language = {eng},
   location = {Oxford},
   pages = {29a},
   publisher = {Oxford University Press},
   title = {Telomerase activity and expression in the course of treatment of acute childhood leukemias},
   year = {2000}
}

TY  - JOUR
ID  - 343215
AU  - Maláska, Jan - Fajkus, Jiří - Bajer, Milan - Hrstková, Hana - Bajerová, Kateřina - Michálek, Jaroslav - Fajkusová, Lenka - Vyzula, Rostislav - Krejčí, Kateřina - Skleničková, Marie
PY  - 2000
TI  - Telomerase activity and expression in the course of treatment of acute childhood leukemias
PB  - Oxford University Press
CY  - Oxford
KW  - Telomerase activity
N2  - Samples of blood and marrow from children with leukemia were assayed for telomerase activity and expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis; it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, suggesting involvement of a telomerase-independent mechanism of telomere elongation.
ER  -

MALÁSKA, Jan, Jiří FAJKUS, Milan BAJER, Hana HRSTKOVÁ, Kateřina BAJEROVÁ, Jaroslav MICHÁLEK, Lenka FAJKUSOVÁ, Rostislav VYZULA, Kateřina KREJČÍ and Marie SKLENIČKOVÁ. Telomerase activity and expression in the course of treatment of acute childhood leukemias. In \textit{Miami Nature Biotechnology Short Reporřts, Volume 11m, Advances in Gene Technology: DNA, RNA and CANCER}. 2000th ed. Oxford: Oxford University Press, 2000, p.~29a, 1 pp. ISSN~1087-0156.

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