| NOVÁKOVÁ, Olga, Ctirad HOFR a Viktor BRABEC. Modification of natural, double-helical DNA by antitumor cis- and trans-[Cl2(Me2SO4)4Ru] in cell-free media. Biochemical Pharmacology. Oxford, UK: Elsevier, 2000, roč. 60, č. 12, s. 1761-1771. ISSN 0006-2952. |
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@article{344039,
author = {Nováková, Olga and Hofr, Ctirad and Brabec, Viktor},
article_location = {Oxford, UK},
article_number = {12},
language = {eng},
issn = {0006-2952},
journal = {Biochemical Pharmacology},
title = {Modification of natural, double-helical DNA by antitumor cis- and trans-[Cl2(Me2SO4)4Ru] in cell-free media},
volume = {60},
year = {2000}
}
TY - JOUR
ID - 344039
AU - Nováková, Olga - Hofr, Ctirad - Brabec, Viktor
PY - 2000
TI - Modification of natural, double-helical DNA by antitumor cis- and trans-[Cl2(Me2SO4)4Ru] in cell-free media
JF - Biochemical Pharmacology
VL - 60
IS - 12
SP - 1761
EP - 1761
PB - Elsevier
SN - 00062952
N2 - Modifications of natural DNA in cell-free media by antitumor ruthenium compounds, cis- and trans-[Cl2(Me2SO4)4Ru] were studied by various biochemical and biophysical methods. The results indicated that both ruthenium compounds irreversibly coordinated to DNA. Several features of DNA binding mode of trans-[Cl2(Me2SO4)4Ru] were similar to those of antitumor cisplatin, which may be relevant to biological effects of this antitumor ruthenium drug. On the other hand, the different DNA binding mode of cis-[Cl2(Me2SO4)4Ru] was consistent with its less pronounced biological effects.
ER -
NOVÁKOVÁ, Olga, Ctirad HOFR a Viktor BRABEC. Modification of natural, double-helical DNA by antitumor cis- and trans-[Cl2(Me2SO4)4Ru] in cell-free media. \textit{Biochemical Pharmacology}. Oxford, UK: Elsevier, 2000, roč.~60, č.~12, s.~1761-1771. ISSN~0006-2952.
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