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@article{344935,
author = {Mohamed, Walid Fathalla and Čajan, Michal and Pazdera, Pavel},
article_location = {Basel},
article_number = {6},
language = {eng},
issn = {1420-3049},
journal = {Molecules},
title = {The Regioselectivity of an Electrophilic Attack on the Thioxo-1,2,4,5-tetrahydro[1,2,4]triazolo[4,3-a]quinazolin-5-one; Part 2.:Reaction on Nitrogen Atom},
volume = {5},
year = {2000}
}
TY - JOUR
ID - 344935
AU - Mohamed, Walid Fathalla - Čajan, Michal - Pazdera, Pavel
PY - 2000
TI - The Regioselectivity of an Electrophilic Attack on the Thioxo-1,2,4,5-tetrahydro[1,2,4]triazolo[4,3-a]quinazolin-5-one; Part 2.:Reaction on Nitrogen Atom
JF - Molecules
VL - 5
IS - 6
SP - 1210
EP - 1210
PB - MDPI
SN - 14203049
N2 - The regioselectivity on a cyclic thioamide group towards different electrophiles was studied on the model compound 4-methyl-1-thioxo-1,2,4,5-tetrahydro[1,2,4]triazolo[4,3-a]quinazolin-5-one 1. The examined compound 1 reacts with alkyl halides, amines in the presence of formaldehyde, acyl halides and compounds having activated double bonds to afford the N-substituted derivatives 2, 3 and 6. The regioselective reactions on nitrogen atom are due to strong Coulombic attraction. The reaction of 1 with amines in the presence of hydrogen peroxide afforded the aminolysis product 4. Compounds 1-6 were identified by FTIR, 1H NMR, 13C NMR, and mass spectroscopy.
ER -
MOHAMED, Walid Fathalla, Michal ČAJAN a Pavel PAZDERA. The Regioselectivity of an Electrophilic Attack on the Thioxo-1,2,4,5-tetrahydro[1,2,4]triazolo[4,3-a]quinazolin-5-one; Part 2.:Reaction on Nitrogen Atom. \textit{Molecules}. Basel: MDPI, 2000, roč.~5, č.~6, s.~1210-1223. ISSN~1420-3049.
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