Polymorphisms in inflammation genes(angiotensinogen, TAP1 and
TNF-beta) in psoriasis

J 2000

Polymorphisms in inflammation genes(angiotensinogen, TAP1 and TNF-beta) in psoriasis

VAŠKŮ, Vladimír, Anna VAŠKŮ, Lydie IZAKOVIČOVÁ HOLLÁ, Svatava TSCHÖPLOVÁ, Kateřina KAŇKOVÁ et. al.

Basic information

Original name

Polymorphisms in inflammation genes(angiotensinogen, TAP1 and TNF-beta) in psoriasis

Authors

VAŠKŮ, Vladimír (203 Czech Republic, guarantor), Anna VAŠKŮ (203 Czech Republic), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic), Svatava TSCHÖPLOVÁ (203 Czech Republic), Kateřina KAŇKOVÁ (203 Czech Republic), Nina BENÁKOVÁ and Věra SEMRÁDOVÁ (203 Czech Republic)

Edition

Archives of Dermatological Research, Germany, Springer, 2000, 0340-3696

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30216 Dermatology and venereal diseases

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.346

RIV identification code

RIV/00216224:14110/00:00002736

Organization unit

Faculty of Medicine

UT WoS

000166251600002

Keywords in English

psoriasis; gene polymorphism; 6p21.3; angiotensinogen; TNF-beta; TAP1; 1q42

Abstract

V originále

This study focused on the association between plaque psoriasis and polymorphisms of several inflamation genes [M235T ATG, A(-6)G ATG], in transporters associated with antigen processing TAP1 (TAP1*0101, TAP*02011 and TAP1*0301 and TNF-beta(NcoI in promoter). Included in the study were 142 Caucasian (Czech)patients with plaque psoriasis and 141 healthy subjects. An increase in B1 allele of NcoI TNF-beta polymorphism was found in psoriatic patients compared to healthy individuals (odds ratio = 1.6; 95% confidence interval 1.13-2.26; P = 0.006). A positive family history of psoriasis was associated with a higher B1 allele frequency in NcoI TNF-beta (P=0.01). A case-control difference was found in the allelic concurrence of M235T and A(-6)G ATG polymorphisms. The most frequent population genotypes MMGG, MTAG and TTAA were observed in 92% of patients vs 74% of control subjects (odds ratio 0,29; 95% confidence interval 0,14-0,60; P = 0.0003).

Links

GA306/93/2192, research and development project

Name: Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense.

Investor: Czech Science Foundation, Polymorphisms of Genes Coding for Angiotensinogen and Angiotensin I Convertase in Essential Hypertension

MSM 141100002, plan (intention)

Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases

VS96097, research and development project

Name: Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of selected multigenic related to civilization diseases

Citovat

VAŠKŮ, Vladimír, Anna VAŠKŮ, Lydie IZAKOVIČOVÁ HOLLÁ, Svatava TSCHÖPLOVÁ, Kateřina KAŇKOVÁ, Nina BENÁKOVÁ and Věra SEMRÁDOVÁ. Polymorphisms in inflammation genes(angiotensinogen, TAP1 and TNF-beta) in psoriasis (Polymorphisms in inflammatin genes(angiotensinogen,TAP1 and TNF-beta) in psoriasis). Archives of Dermatological Research. Germany: Springer, 2000, vol. 292, No 11, p. 531-534. ISSN 0340-3696.

@article{345988,
   author = {Vašků, Vladimír and Vašků, Anna and Izakovičová Hollá, Lydie and Tschöplová, Svatava and Kaňková, Kateřina and Benáková, Nina and Semrádová, Věra},
   article_location = {Germany},
   article_number = {11},
   keywords = {psoriasis; gene polymorphism; 6p21.3; angiotensinogen; TNF-beta; TAP1; 1q42},
   language = {eng},
   issn = {0340-3696},
   journal = {Archives of Dermatological Research},
   title = {Polymorphisms in inflammation genes(angiotensinogen, TAP1 and TNF-beta) in psoriasis},
   volume = {292},
   year = {2000}
}

TY  - JOUR
ID  - 345988
AU  - Vašků, Vladimír - Vašků, Anna - Izakovičová Hollá, Lydie - Tschöplová, Svatava - Kaňková, Kateřina - Benáková, Nina - Semrádová, Věra
PY  - 2000
TI  - Polymorphisms in inflammation genes(angiotensinogen, TAP1 and TNF-beta) in psoriasis
JF  - Archives of Dermatological Research
VL  - 292
IS  - 11
SP  - 531
EP  - 531
PB  - Springer
SN  - 03403696
KW  - psoriasis
KW  - gene polymorphism
KW  - 6p21.3
KW  - angiotensinogen
KW  - TNF-beta
KW  - TAP1
KW  - 1q42
N2  - This study focused on the association between plaque psoriasis and polymorphisms of several inflamation genes [M235T ATG, A(-6)G ATG], in transporters associated with antigen processing TAP1 (TAP1*0101, TAP*02011 and TAP1*0301 and TNF-beta(NcoI in promoter). Included in the study were 142 Caucasian (Czech)patients with plaque psoriasis and 141 healthy subjects. An increase in B1 allele of NcoI TNF-beta polymorphism was found in psoriatic patients compared to healthy individuals (odds ratio = 1.6; 95% confidence interval 1.13-2.26; P = 0.006). A positive family history of psoriasis was associated with a higher B1 allele frequency in NcoI TNF-beta (P=0.01). A case-control difference was found in the allelic concurrence of M235T and A(-6)G ATG polymorphisms. The most frequent population genotypes MMGG, MTAG and TTAA were observed in 92% of patients vs 74% of control subjects (odds ratio 0,29; 95% confidence interval 0,14-0,60; P = 0.0003).
ER  -

VAŠKŮ, Vladimír, Anna VAŠKŮ, Lydie IZAKOVIČOVÁ HOLLÁ, Svatava TSCHÖPLOVÁ, Kateřina KAŇKOVÁ, Nina BENÁKOVÁ and Věra SEMRÁDOVÁ. Polymorphisms in inflammation genes(angiotensinogen, TAP1 and TNF-beta) in psoriasis (Polymorphisms in inflammatin genes(angiotensinogen,TAP1 and TNF-beta) in psoriasis). \textit{Archives of Dermatological Research}. Germany: Springer, 2000, vol.~292, No~11, p.~531-534. ISSN~0340-3696.

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