VAŠKŮ, Anna, Lydie IZAKOVIČOVÁ HOLLÁ and Miloslav KUKLETA. Relations between behavioral risk factors and genomic constitution in essential hypertension. Homeostasis. Praha: Foun. for Stress Prevent. and Behav. Med, 2000, vol. 40, 3-4, p. 149-151. ISSN 1960-7560.
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Basic information
Original name Relations between behavioral risk factors and genomic constitution in essential hypertension
Authors VAŠKŮ, Anna (203 Czech Republic, guarantor), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic) and Miloslav KUKLETA (203 Czech Republic).
Edition Homeostasis, Praha, Foun. for Stress Prevent. and Behav. Med, 2000, 1960-7560.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/00:00002862
Organization unit Faculty of Medicine
Keywords in English ambulatory blood pressure monitoring; smoking; obesity; alcohol consumption; TABP score; emotional load; essential hypertension
Tags alcohol consumption, Ambulatory blood pressure monitoring, emotional load, essential hypertension, obesity, Smoking, TABP score
Changed by Changed by: prof. MUDr. Anna Vašků, CSc., učo 122. Changed: 24/4/2003 10:25.
Abstract
The aim of the study was to associate alleles and/or genotype of the candidate gene polymorphisms for essential hypertension with some known cardiovascular risk factors as blood pressure parameters, smoking, alcohol consumption, obesity, type A behavioral pattern score and emotional load in 202 hypertensives and 196 normotensives subjects. No significant association among the gene polymorphisms and normotensives-hypertensives, blood pressure parameters from ambulatory blood pressure monitoring, smoking, salt consumption, alcohol consumption, BMI were found when single gene differences were calculated. When genotype concurrence of the two polymorphisms was evaluated, marginal association with TABP score was found(P=0.030). Three genotypes (IITT, IDMT, DDMM) were found more frequently in subjects with higher emotional load compared to the other genotype combinations (P=0.064).
Links
GA306/93/2192, research and development projectName: Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense.
Investor: Czech Science Foundation, Polymorphisms of Genes Coding for Angiotensinogen and Angiotensin I Convertase in Essential Hypertension
MSM 141100002, plan (intention)Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
VS96097, research and development projectName: Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of selected multigenic related to civilization diseases
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