1998
Apoptotic DNA fragmentation in tissues of pigs with cardiopulmonary bypass (CPB)
ŠPANOVÁ, Alena; Robert WAGNER; Eva MATALOVÁ; Bohuslav RITTICH; Bedřich UCHYTIL et al.Základní údaje
Originální název
Apoptotic DNA fragmentation in tissues of pigs with cardiopulmonary bypass (CPB)
Autoři
ŠPANOVÁ, Alena; Robert WAGNER; Eva MATALOVÁ; Bohuslav RITTICH; Bedřich UCHYTIL a František KOVÁŘŮ
Vydání
Švédsko, 1 s. The sixth Euroconference on Apoptosis. Abstracts, 1998
Nakladatel
European Hematology Assotiation - ECDO
Další údaje
Jazyk
angličtina
Typ výsledku
Odborná kniha
Obor
Genetika a molekulární biologie
Stát vydavatele
Švédsko
Utajení
není předmětem státního či obchodního tajemství
Označené pro přenos do RIV
Ano
Kód RIV
RIV/00216224:14310/98:00004075
Organizační jednotka
Přírodovědecká fakulta
Změněno: 29. 3. 2001 11:07, doc. RNDr. Alena Španová, CSc.
Anotace
V originále
The goal of this work was to show whether apoptosis would be activated in pigs in the course of cardiopulmonary bypass (CPB), and whether the results obtained on a pig exemplar could be used for the investigation of protection of human myocardium. CPB was carried out by usual procedure on 10 minipigs. Apoptotic cells with extensive DNA fragmentation were found in the bone marrow after chest opening before CPB. This could reflect the reaction of bone marrow to the preoperative stress. After the operation a decrease in the number of nuclei with extensive DNA fragmentation was observed in the tested animals. On the other hand a marked prevalence of bone marrow cells with nuclei with extensive apoptotic fragmentation was found in the dead animals. It was shown that apoptotic DNA fragmentation of myocardial tissue was chiefly all peoved at the end of the operation. However, it was not detected in pulmonary tissues.
Návaznosti
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