Epibatidine and analogs - New trends in the development of cognitive enhancers and strong analgetics

PATOČKA, Jiří; Kräuff SCHWANHAEUSER WULFF a María Victoria MARINI PALOMEQUE. Epibatidine and analogs - New trends in the development of cognitive enhancers and strong analgetics. Vojenské zdravotnické listy. Hradec Králové, Czech Republic: Vojenská lékařská akademie J.E. Purkyně, 2001, roč. LXX, č. 1, s. 33-38. ISSN 0372-7025.

Základní údaje

Originální název

Epibatidine and analogs - New trends in the development of cognitive enhancers and strong analgetics

Název česky

Epibatidine a jeji analogy - Novy trendy

Autoři

PATOČKA, Jiří; Kräuff SCHWANHAEUSER WULFF a María Victoria MARINI PALOMEQUE

Vydání

Vojenské zdravotnické listy, Hradec Králové, Czech Republic, Vojenská lékařská akademie J.E. Purkyně, 2001, 0372-7025

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Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

epibatidine;analgetics;poison-dart frog; alkaloid; nicotinic acetylcholine agonist;dementia;Alzheimer's disease;pain;toxin

Štítky

alkaloid, Alzheimer's disease, analgetics, dementia, epibatidine, nicotinic acetylcholine agonist, pain, poison-dart frog, toxin

Příznaky

Mezinárodní význam, Recenzováno

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Anotace

V originále

Epibatidine, the natural alkaloid isolated from the skin of the Ecuatorian rainforest poison-dart frog. Epipedobates tricolor and some of its synthetically prepared analogs are strong selective agonists of the nicotinic acetylcholine receptors. All of these substances have an analgesic effect and could be used in medical practice. This is very promising for medicine in the fight against pain as well as against dementia, because nicotinic agonists have been found to improve the performance of a variety of memory tasks in rodents and they are probably beneficial in Alzheimer's disease treatment.

Česky

Epibatidine, the natural alkaloid isolated from the skin of the Ecuatorian rainforest poison-dart frog. Epipedobates tricolor and some of its synthetically prepared analogs are strong selective agonists of the nicotinic acetylcholine receptors. All of these substances have an analgesic effect and could be used in medical practice. This is very promising for medicine in the fight against pain as well as against dementia, because nicotinic agonists have been found to improve the performance of a variety of memory tasks in rodents and they are probably beneficial in Alzheimer's disease treatment.