TRÁVNÍČEK, Z., M. MALOŇ, Z. ŠINDELÁŘ, K. DOLEŽAL, J. ROLČÍK, V. KRYŠTOF, M. STRNAD a Jaromír MAREK. Preparation, physicochemical properties and biological activity of copper(II) complexes with 6-(2-chlorobenzylamino)purine (HL1) or 6-(3-chlorobenzylamino)purine (HL2). The single-crystal X-ray structure of [Cu(H+L2)(2)Cl-3]Cl-2H(2)O. Journal of Inorganic Biochemistry. New York, USA: Elsevier, 2001, roč. 84, 1-2, s. 23-32. ISSN 0162-0134.
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Základní údaje
Originální název Preparation, physicochemical properties and biological activity of copper(II) complexes with 6-(2-chlorobenzylamino)purine (HL1) or 6-(3-chlorobenzylamino)purine (HL2). The single-crystal X-ray structure of [Cu(H+L2)(2)Cl-3]Cl-2H(2)O
Autoři TRÁVNÍČEK, Z., M. MALOŇ, Z. ŠINDELÁŘ, K. DOLEŽAL, J. ROLČÍK, V. KRYŠTOF, M. STRNAD a Jaromír MAREK.
Vydání Journal of Inorganic Biochemistry, New York, USA, Elsevier, 2001, 0162-0134.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 10402 Inorganic and nuclear chemistry
Stát vydavatele Spojené státy
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 1.729
Kód RIV RIV/00216224:14310/01:00004175
Organizační jednotka Přírodovědecká fakulta
UT WoS 000168175300004
Klíčová slova anglicky copper(II) complexes; cytotoxic activity; CDK inhibitor; crystal structure;MOLECULAR-STRUCTURE; DIHYDRATE; LIGAND
Štítky CDK inhibitor, copper(II) complexes, Crystal Structure, cytotoxic activity, DIHYDRATE, LIGAND, MOLECULAR-STRUCTURE
Změnil Změnil: doc. RNDr. Jaromír Marek, Ph.D., učo 1989. Změněno: 22. 6. 2001 14:17.
Anotace
Copper(II) complexes of 6-(2-chlorobenzylamino)purine (HL,) and 6-(3-chlorobenzylamino)purine (HL2), respectively, were prepared. Depending on the pH of the medium and the molar ratio of reactants the following mononuclear (trigonal-bipyramidal) and dinuclear (octahedral, trigonal-bipyramidal or tetrahedral) complexes were isolated: [Cu-2(mu -HL1)(2)(mu -Cl-2)(2)(HL1)(2)Cl-2] (1a,b), [Cu-2(mu -Cl)(2)(mu -L-1)(2)(H2O)(2)] (2a), [Cu-2(mu -Cl)(2)(mu -L-2)(2)(H2O)(2)] (2b), [Cu(H+L2)(2)Cl-3]Cl .H2O (3a,b), [Cu-2(mu -Cl)(2)(HL1)(2)Cl-2] (4a), and [Cu-2(mu -Cl)(2)(HL2)(2)Cl-2] (4b). The compounds were characterized by elemental analyses, electronic, infrared and mass (FAB+, ES+) spectral data, magnetic susceptibility temperature dependence measurements and molar conductivity data. An X-ray single-crystal structural analysis of [Cu(H+L2)(2)Cl-3]Cl . 2H(2)O (3b) showed that the Cu2+ ion is penta-coordinated by three chloride ions and by two H+L2 ligands. Thus, the Cu2+ ion adopts a distorted trigonal bipyramidal coordination geometry with the protonated H+L2 ligands coordinated in trans apical positions, while the three chloride ions are situated in an equatorial plane. The cytotoxic activity of the complexes was determined by a calcein AM assay. Mouse melanoma cell line B16-FO, human malignant melanoma cell line G361, human osteogenic sarcoma cell line HOS and human breast adenocarcinoma cell line MCF7 were used. IC50 values, the drug concentrations lethal to 50% of the tumor cells, were estimated. One of the important mechanisms responsible for the cytotoxicity of cytokinin-derived compounds, the inhibition of cyclin-dependent kinases by the studied complexes, was also determined. (C) 2001 Elsevier Science B.V. All rights reserved.
Návaznosti
GA203/00/0152, projekt VaVNázev: Syntéza, studium a biologická aktivita komplexních sloučenin vybraných přechodných kovů s purinovými deriváty
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