New and facile method of preparation of the anti-HIV-1 agent,
1,3-dicaffeoylquinic acid

J 2001

New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid

SLANINA, Jiří; Eva TÁBORSKÁ; Hana BOCHOŘÁKOVÁ; Iva SLANINOVÁ; Otakar HUMPA et al.

Základní údaje

Originální název

New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid

Název česky

Nová a snadná metoda přípravy anti-HIV-1 činidla, 1,3-dicaffeoylchinové kyseliny

Autoři

SLANINA, Jiří; Eva TÁBORSKÁ; Hana BOCHOŘÁKOVÁ; Iva SLANINOVÁ; Otakar HUMPA; W. Edward ROBINSON a Karl H. SCHRAM

Vydání

Tetrahedron Letters, Oxford, Pergamon - Elsevier Science, 2001, 0040-4039

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10401 Organic chemistry

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.280

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/01:00004264

Organizační jednotka

Lékařská fakulta

UT WoS

000168404000036

Klíčová slova anglicky

Antivirals; biologically active compounds; isomerisation; phenolics; tannins

Štítky

Antivirals, biologically active compounds, isomerisation, phenolics, tannins

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 6. 2009 00:20, Mgr. Jiří Slanina, Ph.D.

Anotace

ORIG CZ

V originále

A facile and inexpensive preparation of 1,3-dicaffeoylquinic acid (cynarin) from the leaves Cynara cardunculus L. (Asteraceae) without the use any chromatographic steps is described. The procedure was based on separation of the fraction rich in 1,5-dicaffeoylquinic acid, isomerisation of 1,5-dicaffeoylquinic acid to cynarin and, owing to its higher polarity, the simple isolation of cynarin from the reaction mixture. Cynarin inhibited HIV-1 replication in MT-2 cell culture at nontoxic concentrations similar to other previously tested dicaffeoylquinic acids, which have been recently established as a potent and highly selective class of HIV-1 integrase inhibitors.

Česky

Nová a snadná metoda přípravy anti-HIV-1 činidla, 1,3-dicaffeoylchinové kyseliny je popsána

Návaznosti

GA303/00/D062, projekt VaV

Název: Biologická dostupnost a mechanismus antioxidačního účinku fenolických kyselin a lignanů

Investor: Grantová agentura ČR, Biologická dostupnost a mechanismus antioxidačního účinku fenolických kyselin a lignanů

Citovat

SLANINA, Jiří; Eva TÁBORSKÁ; Hana BOCHOŘÁKOVÁ; Iva SLANINOVÁ; Otakar HUMPA; W. Edward ROBINSON a Karl H. SCHRAM. New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid. Tetrahedron Letters. Oxford: Pergamon - Elsevier Science, 2001, roč. 42, č. 19, s. 3383-6767. ISSN 0040-4039.

@article{365191,
   author = {Slanina, Jiří and Táborská, Eva and Bochořáková, Hana and Slaninová, Iva and Humpa, Otakar and Robinson, W. Edward and Schram, Karl H.},
   article_location = {Oxford},
   article_number = {19},
   keywords = {Antivirals; biologically active compounds; isomerisation; phenolics; tannins},
   language = {eng},
   issn = {0040-4039},
   journal = {Tetrahedron Letters},
   title = {New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid},
   volume = {42},
   year = {2001}
}

TY  - JOUR
ID  - 365191
AU  - Slanina, Jiří - Táborská, Eva - Bochořáková, Hana - Slaninová, Iva - Humpa, Otakar - Robinson, W. Edward - Schram, Karl H.
PY  - 2001
TI  - New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid
JF  - Tetrahedron Letters
VL  - 42
IS  - 19
SP  - 3383
EP  - 3383
PB  - Pergamon - Elsevier Science
SN  - 00404039
KW  - Antivirals
KW  - biologically active compounds
KW  - isomerisation
KW  - phenolics
KW  - tannins
N2  - A facile and inexpensive preparation of 1,3-dicaffeoylquinic acid (cynarin) from the leaves Cynara cardunculus L. (Asteraceae) without the use any chromatographic steps is described. The procedure was based on separation of the fraction rich in 1,5-dicaffeoylquinic acid, isomerisation of 1,5-dicaffeoylquinic acid to cynarin and, owing to its higher polarity, the simple isolation of cynarin from the reaction mixture. Cynarin inhibited HIV-1 replication in MT-2 cell culture at nontoxic concentrations similar to other previously tested dicaffeoylquinic acids, which have been recently established as a potent and highly selective class of HIV-1 integrase inhibitors.
ER  -

SLANINA, Jiří; Eva TÁBORSKÁ; Hana BOCHOŘÁKOVÁ; Iva SLANINOVÁ; Otakar HUMPA; W. Edward ROBINSON a Karl H. SCHRAM. New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid. \textit{Tetrahedron Letters}. Oxford: Pergamon - Elsevier Science, 2001, roč.~42, č.~19, s.~3383-6767. ISSN~0040-4039.

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