BUČKOVÁ, Dana, Lydie IZAKOVIČOVÁ HOLLÁ, Petr BENEŠ, Vladimír ZNOJIL and Jiří VÁCHA. TGF-beta1 gene polymorphisms. Allergy. Denmark: Munksgaard International Publishers, 2001, vol. 56, No 12, p. 1236-1237. ISSN 0105-4538.
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Basic information
Original name TGF-beta1 gene polymorphisms
Authors BUČKOVÁ, Dana (203 Czech Republic, guarantor), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic), Petr BENEŠ (203 Czech Republic), Vladimír ZNOJIL (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic).
Edition Allergy, Denmark, Munksgaard International Publishers, 2001, 0105-4538.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher Denmark
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.852
RIV identification code RIV/00216224:14110/01:00004361
Organization unit Faculty of Medicine
UT WoS 000172476700031
Keywords in English gene; polymorphism; allergy; TGF; asthma
Tags allergy, asthma, gene, polymorphism, TGF
Changed by Changed by: prof. MUDr. Lydie Izakovičová Hollá, Ph.D., učo 734. Changed: 17/6/2009 12:52.
Abstract
Transforming growth factor beta (TGF-beta) is a pleiotropic cytokine with significant anti-inflammatory and immunosuppressive properties. The single base pair polymorphism located at -509 (C/T) in the promoter region of the TGF-beta1 gene was previously shown to be associated with elevated total serum IgE levels. We tested the hypothesis that polymorphic alleles of the TGF-beta1 gene are associated with allergies and asthma.
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MSM 141100002, plan (intention)Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
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